norbuprenorphine is responsible for the high at small doses (<1mg), it is a full agonist and as long as you dont take enough bupe to use up all your my receptors, the norbuprenorphine will be able to bind to them, giving a more full agonist feel
...deja vu.
of course I didnt mean to be rude or sarcastic to him, i was simply stating that i wasnt sure who he directed that post towards because no one really asked about norbupe.....
...no rudeness intended, because what he said was 100% correct, ecxept for the fact that he didnt make it very clear what norbupe was or where it comes from......which, as i think you know, it is a full-agonist metabolite of bupernorphine with a lesser binding affinity.
As another poster pointed out, he probably did do it to sound smart. And I am pretty sure he doesn't know very much (if anything at all) about Norbupe. If he did know a thing or two about Norbuprenorphine he would have given us his own response instead of one copied from Opiophile.
i think he just said that as information, and to appear smart.
well he succeeded!!![]()
I don't know about that one. Not only did PoppyLlama copy that post, but he also didn't even explain why NorBupe pertains directly to this thread. He also made a few minor details messy or just didn't include them at all. Like the fact that Norbuprenorphine mainly effects the G.I. tract and it cannot cross over the blood-brain-barrier nearly as efficiently as Bupe can. Also NorBupe is only a full antagonist at nociceptin, (partial at Kappa and Delta, not sure about mu). As the good doc said: "Pure norbuprenorphine would be extremely unpleasant, due to its stimulating/agonist effects at the kappa and nociceptin receptors: it would be a strongly anxiogenic, mildly to strongly dysphoric, and delirium-inducing/hallucinogenic compound"
P.S. I am not trying to be an asshole or anything like that, I just feel it is important on forums like this to give out safe and correct information.