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Potentiating or Prolonging Methylone?

Marauder

Marauder

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Methylone! My all-time favorite drug. It fixes my life 100% until an hour later when it begins to wear off :| so let's get this thread going.

Here are some possibilities:

1) Taking piracetam 1-2 hours beforehand. In my experience it sort of changes the methylone high but doesn't necessarily potentiate it. It makes me more functional and improves memory but at 2-3g 1hr beforehand the effects are subtle.

2) Taking 5-HTP 1-3hr beforehand. Doesn't seem to do much in my experience. Perhaps dosing 5-HTP every day and causing it to build up will have an effect down the road? Or it will help with serotonin recovery after methylone wears off? Probably doesn't make much of a difference. Post your results plz.

3) Eating something alkaline. This works very well for adderall (there's a warning on the box.) Calcium carbonate or baking soda taken before/with the methylone MIGHT increase absorption. I've tried both of those and methylone on its own. No major difference between them. Perhaps I didn't use enough, and/or should have taken it 1-2 hours before the methylone?

4) An MAOI - probably works but chance of fatal interaction is very high. I might experiment with taking syrian rue (a little bit) an hour before and then taking 1/4th the methylone dose and working up. Again, this is very dangerous. MAOIs may kill you. Fatal means it brings death. Don't be stupid!

5) OTC supplements and herbs. SAMe, St John's Wort (weak MAOI or SSRI?) ? grapefruit extract?

6) SSRIs? They only blunt the empathogenic effects of the drug IME.

7) Rectal administration. No experience but willing to give it a go down the road.

8) This works for me: Some people say redosing doesn't work, but I have found that if you redose higher, it works and the pleasure comes in waves. For example, dosing 150mg, waiting 30 mins and dosing another 200mg, waiting 45-1hr and dosing 250mg. It's not a safe practice, but if you're gonna redose and you plan on staying up for a long time, it's probably more effective than a small booster dose. The crash is obviously going to be worse but not much so.

9) Wellbutrin? This is safe to take with methylone but I'm not sure if it changes the effects of the drug very much. Wellbutrin (bupropion) acts as a dopamine/norepinephrine reuptake inhibitor but also as a dopamine release inhibitor, meaning it keeps your dopamine at a constant level. This probably results in the methylone feeling slightly less dopaminergically pleasurable (but not any less empathogenic) - but in my experience, it also reduces a lot of the crash which is probably due to dopamine depletion rather than serotonin depletion. This is also the case with adderall-where I don't feel that euphoric taking it, but I still get the +focus benefits of the drug. This was my 2 cents with my experience of wellbutrin SR 200mg 2x a day.

(for the record, Wellbutrin and DXM even in medicinal Robitussin doses is unpleasant and may be dangerous. I'm surprised there's no warning about this on the box. I found out the hard way. I read a report of a guy who's DXM trip lasted 2-3 days due to wellbutrin.)

Does anyone have other suggestions? I'm looking to either potentiate the effects without diminishing the already short duration of the drug, OR to simply extend the duration of the effects as they are.

My regular dose is 200-250mg in a gelcap with calcium carbonate, chased with a 50-100mg cap 20-30 mins after. I sometimes go with #8 above but only if I'm staying out and have a place to be when I'm coming down.
 
Thanks for listing these, do you have a goal in mind for this thread like do you want to hear about other peoples experiences with potentiating methylone?

I assume so, well I have tried both piracetam and something alkaline (in my case Maalox) and they worked quite good without feeling like it's an especially unhealthy idea. Mixing piracetam is not something I would recommend to people right off the bat but antacids like Maalox are dandy.
 
I find redosing works pretty well for me. Typically I start out with a dose of 175-250 mg then about t1:30 or t2 take another 100-150 mg. This will provide a very decent 4-5 hour experience with minimal after effects and only a mild hang over the next day, if any. If I decide to take a second redose (usually around 100-150 mg again) it is usually around t3 ot t3:30. Once again the redose works and will provide me with a very strong 5-6 hour experience, but I can pretty much be guranteed to have a pretty hefty crash and pretty shitty next day, and maybe even vomitting.
 
Ohh yes I find one redose almost obvious, even though it might not be. After a second one the longer you continue the more stimmy it gets, the same as with many other empathogens if not all.

Indeed one redose allows the timeframe to be a 5 hour span (almost or entirely) which is similar to MDMA or a good part of a party night which is the measurement against which many things are met.
 
I've read a few very positive reports here (methylone megathread) about combining it with MDAI. It should make it more like MDMA or even more euphoric, some even find the combo better than (real) MDMA. (IIRC dosages were like 100 mg MDAI+180 mg methylone.

Methylone is good at releasing dopamine (and reuptake) but it's serotonin releasing ability is much smaller than MDMA's, hence not the hyper-empathetic feeling. MDAI as a selective serotonin releasing agent sounds reasonable. and quite safe.

BTW:Does someone have the chart where the releasing ability of SE/DA with methylone and MDMA are compared?
 
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careful though with mdai and methylone, ive found increased side effects from using them at the same time, especially when it comes to prolongued insomnia and speediness afterwards.
 
I found taking 2g of Piracetam (plus a choline source like DMAE/alpha-GPC/Lecithin/Choline-Inositol_caps) 1 hour before the Methylone DOES for me not only deepen the "Euphoria" phase, but also lengthens it some.

I found taking like one teaspoon of baking soda EXACTLY 10 minutes prior to the methylone... need to give it time to work but not too long or it is absorbed and the effect is gone... DEFINITELY made the Methylone stronger, as if I had done a larger dose, and maybe slightly longer but not by much, mostly just potentiated the dose. Beware however... this also seemed to quite reliably cause totally liquid, um, excretion a few hours later... just a little heads up, or um down, as the case may be, haha.

I have also heard tales of boosting the methylone with other stimulants, in particular, I believe someone once recommended 4-mmc, i.e., mephedrone... or was it 4-FMP, with it to me as being particularly fantastical. Perhaps it was the latter as THIS link describes it as a strong serotonin releaser, and Methylone releases SOME serotonin, but not as much as MDMA... waring - the lower but still entactogenic - release of Serotonin as compared to MDMA is probably the cause of the lower "LOVINESS" feelings of methylone, but probably ALSO LESS day after burnout so often reported after MDMA, but rarely from Methylone.
 
150mg MDAI and 200mg Methylone dissolved in water at the same time, with oxiracetam an hour before yielded total bliss for me, lasting a good six hours. Just as good as my best roll. The comedown was no worse than any other methylone comedown.
 
check out the mdai batches too, you wouldnt want any of the really impure stuff that was going around some time ago.

also, i could vouch for the 4fa+m1 combo, if not for the really uncomfortable comedown, which was way too speedy for my liking. it is also quite the challenge to mix the two satisfactorily, as one lasts ~10h and the other just 4. just be careful with this one mix (also, depending where you live, chances are high that 4fa is illegal)
 
reddenedxsky said:
150mg MDAI and 200mg Methylone dissolved in water at the same time, with oxiracetam an hour before yielded total bliss for me, lasting a good six hours. Just as good as my best roll. The comedown was no worse than any other methylone comedown.
Click to expand...

Thanks alot for the tip. I am guessing most of the racetams, in a good sized single dose an hour prior will give a noticeable boost.

Oh and OOPS, here's the link that makes 4-fmp sound particularly interesting as a possible combinant/booster: http://research-chemicals-legal-highs-en.blogspot.com/

Apparently "4fa" == "4-fmp"... more good chat here, though not alot on the combo with M1: http://www.drugs-forum.com/forum/showthread.php?t=9273

But as these are stims, as is M1, one ought be VERY conservative in dosing... such that a good initial guideline is the total combination of the two not exceed a typical 175mg dose of plain M1.
 
Hi to all, i'm reading for months now, but had to register finally and share some of my exp :)

i experimented A LOT with boosting M1 in intensity and lengh. Just love that stuff as it gives me almost no hangovers but some nice afterglowing and awesome weekstarts.
Needless to say, your best bet is a good & healthy diet (lots of bananas, eggs, red meat) prior to your roll and a minimum 2 Week break for a good body load to build up naturally.

My quest to imitate MDMA (in intensity and duration) with M1 goes as follows (i'm generally pretty resistant to stims, so my doses are always a bit on the upper end)

200mg M1 was my standard dose prior to combining it, never redosed or bumped. sometimes it was good, sometimes too weak or short.

failures:
150mg M1 + 100mg 4-FA - too soft, too unpronounced, not quite wavy, more talky than dancy.
150mg M1 + 150mg 4-FMC - quite the same, too speedy, too far off the bliss of magic.
150mg M1 + 150mg MDAI - almost sedating, i found this the most boring combo of all.

win:
200mg M1 + 15mg MDPV - this is almost like MDMA crystals, extremely awesome bodyload and a quite good boost in duration and energy from the PV, had also awesome wavy feel and dancing is like heaven on this combo
250mg M1 + 25mg MDPV - gives a very strong good body load, but already feels a bit to much, comedown is pretty harsh due to PV overstimulation.

I'm definitly gonna stick to 200mg M1 + 15mg MDPV, this combo is the perfect MDMAesque roll for me.

Gonna try the Grapefruit-Boosting on new years eve and look if it does something.

stay safe!
lip
 
what is this grapefruit boosting you speak of? above there is a mention given to eating alkaline foods (or taking maalox to reduce stomach acidity) to increase absorption... but thats the opposite of grapefruid juice (which is acidic)

also, 15mg MDPV? oral? isnt that.. like... yknow... quite the dose? im only asking because you did mention you need a little more than average and was just curious as to what your normal solo mdpv dose would be.

150 m1 with 100 4fa for me would be probably the best... thats if i ever get the nerve to go for it, usually the 4fa is enough for me... but friends experimenting have said 100-150 4fa goes swimmingly with ~150-200 methylone...

but i digress. these are more combos than actual potentiatiors of methylone, no? perhaps this info is worth mentioning in that thread as well?
 
Indeed dwayne, 4-fa and m1 is one of the best mixes out there. Same with 4mmc and m1.

Also, with regard to plugging, it is IMO by far the best way to take methylone. The duration is mostly unchanged, slightly shorter, and the high (specifically the rush on the come up) is RIDICULOUSLY strong, like 3x stronger than oral at least. If you take a starter oral dose, a plugged redose will be as strong as the oral dose. God, it's amazing.
 
Marauder said:
2) Taking 5-HTP 1-3hr beforehand.
Click to expand...

If you wanted to potentiate M1, you would want dopamine or norepinephrine precursors like tyrosine or n-acetyl tyrosine. Just be careful with these though because they alone can cause increased heart rate if you are not used to them and take a good dose.

I think I puked one night after drinking just a few sips of an energy drink w/ n-acetyl tyrosine in it when I was on a good amount of M1. Not from heart issues, just nausea and being really sped.
 
Do you have any evidence behind any of these potentiating methods maurauder? For example, I thought mixing an MAOI with MDMA was a good way of killing yourself. Is it different with methylone?
 
I have to agree with PsychedelicPeptide, 5-HTP doesn't have the same potentiating effect as it would have on drugs like MDMA or Mephedrone since Methylone is less about serotonin and more about dopamine. I've personally tried preloading 5-HTP before methylone and never noticed a change (if anything it created unfulfilled expectations that hurt the roll)

Unfortunately the only way to truly make a methylone roll longer is to redose after 1/1.5 hours from the initial dose, and it does bring out the negative effects and speediness.
 
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