Temazepam script

[Escapedysphoria]

I just got a script of 15 mg temazepam (restoril) and it is by far the most euphoric benzo i have ever had (i've also tried xanax, klonopin, ativan, and valium countless times). What about temazepam makes it the better and more euphoric benzo? Is it the very very slight almost "opiate buzz" it gives off?

 

[kokaino]

Of course, temazepam is the most widely abused benzo on a global scale. It's the most popular.

It's heavily abused in Europe (where in some countries it's abuse is/was at epidemic proportions and some countries banned it now). Asia has a similar problem with temazepam, especially Southeast Asia (together with nimetazepam). It's commonly abused in South Africa, especially as a downer for meth binges (Mandrax is also used in that country).

Temazepam is even illicitly manufactured and distributed in Europe - so yes, temazepam is one hell of a benzo.

 

[K'd-OUT-in-AZ]

What about temazepam makes it the better and more euphoric benzo? Is it the very very slight almost "opiate buzz" it gives off?

Not everyone finds it the most euphoric benzo. I do personally. I think its because it has a good balance of anxiolytic, hypnotic and muscle relaxant properties. Hypnosis being the most predominant.

 

[mgrady3]

I find it to have a longer onset, but then definitely a more euphoric buzz compared to xanax or clonazepam.

As k'd out said, Tpam just has the best overall mix of benzo qualities that give it the special "euphoria." Note here, euphoria has to be considered in the benzo sense. For those who suffer anxiety based problems, the combination Temazepam provides of anxiolytic, hypnotic and muscle relaxant qualities.

I am tempted to say I enjoy it most for its muscle relaxing ability in combination with its other abilities. It helps me get to sleep not by just being a hypnotic but by also providing anxiety relief and also muscle relaxation. I often can't sleep due to pains from my knees and legs (bad knees both genetic and sports related) and commuting via bike and teaching. S my legs are often tired/sore/strained at the end of the day. So Temazapem just helps me feel better at the end of the night.

 

[BrokedownPalace]

I am currently prescribed klonopin for anxiety related insomnia and shit, and it works fine, but I have been very interested in restoril for quite some time, my roomate in rehab was prescribed it and he would give me one here and there, and I have to agree they were quite good. I am in the process of finding a new shrink who will accept Medicaid (which is a fucking task, let me tell you..) and I want to try and get my klonopin switched over to temazepam.

 

[phatass]

i don't exactly know why temazepam is so much more euphoric than for example kpin or xanax... but i do know that its a hypnotic, as opposed to an anxiolytic (all the other benzos you stated r anxiolytics)... i find hypnotics like loprazolam, lormetazepam, temazepam, midazolam etc more euphoric too, they act on different gaba recpetors than anxiolytics, which may partly explain

 

[mgrady3]

Temazepam exhibits 3 common benzo qualities all at once. It acts as a hypnotic, an anxiolytic, and a skeletal muscle relaxant. So it binds sufficiently well to multiple sub sites at the GABA_A receptor, notably probably a mixture of the first 3, alpha 1-3. These sub receptor sites trigger sedation, anxiolysis, and muscle relaxation. I think it is this special combination that makes Temazepam unique.

Perhaps it binds with slightly more affinity to the GABA_A_a1 which would make it lean more toward sedation/hypnotic properties. However, because it also binds to a2 and a3, you get the mixture of anti anxiety and muscle relaxation.

Temazepam also has a fairly medium length half life (8 hours, here) which makes it great at night.

 

[kokaino]

Temazepam is actually an highly potent anticonvulsant. It has been used to treat epilepsy in adults. It belongs to the 3-hydroxy family of benzos, which are all extremely potent anticonvulsants.

 

[K'd-OUT-in-AZ]

they act on different gaba recpetors than anxiolytics, which may partly explain

No, anxiolytics and hypnotics don't act on different GABA receptors. All benzodiazepines act on the same receptors. Benzodiazepines are non-selective which means that they (anxiolytics, hypnotics) have action on all 4 GABA alpha subunits. a1, a2, a3 & a5. Hypnotics just have more action on the a1 subunit while anxiolytics have more action on the a2 & a3 subunits.

 

[Bitter and Tainted]

Temazepam is on my "drugs to do before I die" list...

and just to add...

I feel really fucking dumb around you guys...you're so smart 8)

*reaches for book instead of pill bottle*

 

[kokaino]

No, anxiolytics and hypnotics don't act on different GABA receptors. All benzodiazepines act on the same receptors. Benzodiazepines are non-selective which means that they (anxiolytics, hypnotics) have action on all 4 GABA alpha subunits. a1, a2, a3 & a5. Hypnotics just have more action on the a1 subunit while anxiolytics have more action on the a2 & a3 subunits.

They also act on γ2 subtype and β3 subtype receptors. The former mediates phhysical dependence and respiratory depression and the latter mediates anti-convulsive, minor sedation, muscle relaxation, various other reactions related to respiration. The β3 receptor subtype is a barbiturate receptor, and temazepam has very high affinity to it (one of the few benzo's which have such a high affinity to this receptor subtype) - which could explain its toxicity.

 

[phatass]

No, anxiolytics and hypnotics don't act on different GABA receptors. All benzodiazepines act on the same receptors. Benzodiazepines are non-selective which means that they (anxiolytics, hypnotics) have action on all 4 GABA alpha subunits. a1, a2, a3 & a5. Hypnotics just have more action on the a1 subunit while anxiolytics have more action on the a2 & a3 subunits.

sorry, you allready corrected me last time lol.... i had the right vibe, not the right info though... thanks k-d out

 

[K'd-OUT-in-AZ]

No prob Bob