• BASIC DRUG
    DISCUSSION
    Welcome to Bluelight!
    Posting Rules Bluelight Rules
    Benzo Chart Opioids Chart
    Drug Terms Need Help??
    Drugs 101 Brain & Addiction
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums
  • BDD Moderators: Keif’ Richards

Strongest opioid and Opiates

Status
Not open for further replies.
its true that fentanyl is more potent than oxycodone Its a fact. does anyone know about codeine contin?Im curious about it I can't take tramadol anymore it just doesn't work for my back pain and codeine seems to be the same or about the same potency or strength but I heard it doesn't contain Tylenol which is bad for the liver could I get some help on this???
 
lordreven333 said:
its true that fentanyl is more potent than oxycodone Its a fact. does anyone know about codeine contin?Im curious about it I can't take tramadol anymore it just doesn't work for my back pain and codeine seems to be the same or about the same potency or strength but I heard it doesn't contain Tylenol which is bad for the liver could I get some help on this???
Click to expand...

Most formulations of codeine here in the US do contain APAP. If tramadol doesn't work for you anymore, and you are nervous about your liver, then a doctor would probably prescribe you oxycodone with no APAP next. Codeine is quite weak, but a bit better than tramadol in my experience. If you don't have a huge tolerance, codeine can be fairly effective. Just don't take more than 400mg at a time.
 
Yeah, really. This point of this forum is to spread true information about drugs. Telling people things are stronger than other things when they certainly are not is about as helpful to harm reduction as making your high school's D.A.R.E. officer the Senior Moderators.

So, let's set this straight.

-- Fentanyl is the strongest prescribed opioid, yes, there are others around, but they're used to sedate elephants and as chemical weapons (no, I'm not kidding, click the links).

-- Oxymorphone, hydromorphone, morphine, methadone, buprenorphine (Suboxone), heroin (diamorphine) are some of the strongest semi-synthetics commonly available. StaySedated mentioned some other less common ones. Wikipedia has them all, check it out.

Also, please check out a opiate conversion chart, all this information is right there.

@BrokedownPalace, yes, most formulations of codeine in the US are a form of the Tylenol 1, Tylenol 2, Tylenol 3 or Tylenol 4 series, all of which have APAP in them. I agree that codeine is better than tramadol, however tramadol has other effects which one may consider desirable for certain pain situations. That's between you and your doctor. If those don't work, then its most likely oxycodone with no or very little APAP in it, as Brokedown said.

Please do your research when it comes to opiates/opioids. Once you start getting into the strong stuff it really does matter a lot if you take 10mg or 1mg. So, yes, HIPPIE is wrong, very very wrong.
 
orally:
propoxyphene>codeine>hydrocodone>morphine/heroin>oxycodone>methadone>hydromorph>oxymorph>levorphanol


IV:
hydrocodone>oxycodone>methadone>morphine>heroin>hydromorph>oxymorph>fentanyl


most euphoric to me are heroin/morphine - nothing beats the original standard opiate!
 
Dj Jimmy H said:
freak
Click to expand...

rooster.jpg
 
oxycodone is a bit strong I have no problem taking it but the doctors would not prescribe that for my back pain it isn't severe enough for that yet what about hydrocodone can I get that without the apap? or anything else more strenth then tramadol but less than oxycodone???
 
Most potent "prescribed" opiates (ORAL) from top to bottom (not including heroin):
Sufentanyl
Fentanyl
Oxymorphone
Levorphanol
Hydromorphone
Methadone
Oxycodone
*Buprenorphine
Morphine
Hydrocodone
Codeine
Meperidine
Propoxyphene
Tramadol

These are according to mg-to-mg basis. Tramadol and Propoxyphene are tied for last. Buprenorphine was placed on my opinion because conversion charts are hard to find with it.
 
for IV it's more like this (from top to bottom):

Fentanyl
Oxymorphone
Levorphanol
Hydromorphone
Diamorphine (heroin)
Morphine
Methadone
Oxycodone
Hydrocodone
Codeine (although you cannot IV this).
 
K'd-OUT-in-AZ said:
I'd switch Levorphanol with Heroin and put Oxycodone above Methadone. Hydrocodone and Codeine shouldn't even be on that list.
Click to expand...

Heroin is less potent than levorphanol and hydromorphone by the IV route.

Heroin is a morphine prodrug and studies have shown it's only 1.5-2.5x more potent than morphine (this increase of potency is only because of heroin's lipid solubility - but the drug is essentially morphine in every way - morphine is responsible for all of "heroins" subjective effects of euphoria, sedation, respiratory depression, etc), whilst hydromorphone is approx. 7x more potent than morphine and levorphanol about 8-10x more potent.

I'm not sure about the methadone and oxycodone switch, you may be right but somehow I don't think so because from what I've read is that methadone is more potent than oxycodone all around (it has a high oral BA, and is equally as potent IV - so I just don't see how methadone can be less potent). But I am not sure, and you may be right I don't know.
 
Last edited:
kokaino said:
orally:
propoxyphene>codeine>hydrocodone>morphine/heroin>oxycodone>methadone>hydromorph>oxymorph>levorphanol


IV:
hydrocodone>oxycodone>methadone>morphine>heroin>hydromorph>oxymorph>fentanyl
Click to expand...
I'm sure it's just a matter of putting > where you meant <, but those are completely backwards.
 
kokaino said:
Heroin is less potent than levorphanol and hydromorphone by the IV route.

Heroin is a morphine prodrug and studies have shown it's only 1.5-2.5x more potent than morphine (this increase of potency is only because of heroin's lipid solubility - but the drug is essentially morphine in every way - morphine is responsible for all of "heroins" subjective effects of euphoria, sedation, respiratory depression, etc), whilst hydromorphone is approx. 7x more potent than morphine and levorphanol about 8-10x more potent.

I'm not sure about the methadone and oxycodone switch, you may be right but somehow I don't think so because from what I've read is that methadone is more potent than oxycodone all around (it has a high oral BA, and is equally as potent IV - so I just don't see how methadone can be less potent). But I am not sure, and you may be right I don't know.
Click to expand...

Oxycodone & Methadone are listed to be equivalent in potency 20mg = 20mg (short term, not chronic) but Methadone isn't much more potent at all the IV route, I mean basically no difference at all just a quicker onset. Its listed to be twice as potent the IV route. I can't find a conversion chart that lists IV Oxycodone but it feels more potent the IV route. So that is what I go by.
 
K'd-OUT-in-AZ said:
Oxycodone & Methadone are listed to be equivalent in potency 20mg = 20mg (short term, not chronic) but Methadone isn't much more potent at all the IV route, I mean basically no difference at all just a quicker onset. Its listed to be twice as potent the IV route. I can't find a conversion chart that lists IV Oxycodone but it feels more potent the IV route. So that is what I go by.
Click to expand...

You may be right, as I have never seen IV methadone listed on any chart. I have seen oxycodone listed, however.

I had a book years ago that I took from my aunt (who is a dentist) that she had from dental school. It was a Pharmacology book and it had a chart that compared various opiates through the IV route.

Here is how it was:

Morphine IV 10 mg =

Heroin 5 mg (2x more potent than morphine)
Hydromorphone 1.5 mg (7x more potent than morphine)
Fentanyl 0.1 mg (100x more potent than morphine)
Oxymorphone 1 mg (10x more potent than morphine)
Levorphanol 2 mg (5x more potent than morphine)
Oxycodone 20 mg (morphine is 2x more potent)
Meperidine (Demerol) 75 mg (morphine is 7.5x more potent)
Buprenorphine 0.5 mg (20x more potent than morphine)

So the list would actually go something like this:

Fentanyl
Buprenorphine
Oxymorphone
Hydromorphone
Levorphanol
Heroin
Morphine
Oxycodone
Demerol

I'm not including methadone on the list because I've never seen any real data for it the IV route. My gut feeling however tells me it's more potent than oxycodone both orally and intravenously. Methadone is an highly potent narcotic, while oxycodone is more unstable as it is quite potent orally, but loses much of it's potency IV. It's slightly more potent than morphine orally, but as you can see - morphine is 2x more potent intravenously. If I had to guess though, I'd say that 15 mg of methadone = 10 mg morphine IV.
 
Last edited:
along time ago when i was on a methadone programme in the uk i was getting methadone ampoules 1ml=50mg it did hit you quicker than orally but not that much and imo when injected didnt seem to last as long as when orally used it was only useful if you had a needle fixation
 
Status
Not open for further replies.
Top