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The Big & Dandy Trip Abortion Thread

You want to look for the agonest to the antaogest of vice versa for the substance, what will reverse the action it is taking on the receptors in the brain.
 
^^^ Yes, but sometimes it's safer (and more accessible) to treat a bad trip symptomatically then directly.

plus that's a very simplistic view on treating psychedelic induced psychosis :)
 
Delsyd said:
i dont know too much about this stuff but i think the other ones you mentioned are also 5ht agonists.
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DMT, aMT, 6-APB and MDMA are serotonin releasers. aMT, 6-APB and MDMA are also dopamine releasers. 5-MeO-MiPT is a serotonin reuptake inhibitor. DMT inhibits VMAT-2 and agonizes TAAR1, and has affinity for the dopamine D1, α1-adrenergic, α2-adrenergic, imidazoline-1, sigma-1 receptors. All of those mentioned (except 6-APB) also have significant activity at 5ht2c which is not blocked by most antipsychotics, and aMT and 5-MeO-MiPT have action at 5-ht3. aMT furthermore inhibits monoamine oxidase. This is ignoring functional selectivity/affinity and the fact that atypical antipsychotics typically only block 5-ht2 receptors and the main target of antipsychotics is D2-like receptors, inhibition of which has not been shown to end a psychedelic experience. 6-APB, aMT, and 5-MeO-MiPT are poorly studied and likely have significant affinity at multiple unknown receptors. Most importantly, though, DMT and MDMA have significant affinity at 5-ht2b, which is not blocked by antipsychotics but is very important in their toxicology profile!

Just because a drug has some 5-ht2a affinity does not mean that it is advisable or even safe to use antipsychotics to halt the experience. Many antipsychotics have a rather complex pharmacology, particularly including antagonism at H1 and mAChR as well as inhibition of SERT and NET, which isn't always good to combine with psychedelics.

Benzodiazepines are standard-of-care because they are very safe and very well-tested.

(edit: because the dmt-serotonin-release thing is not well known, here's the source)
 
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i think changing the setting to something less stimulating would instantly make the trip seem milder

e.g. somewhere quieter, darker, with less people

i also like the bucket of water idea! i can see that changing things
 
LSD and psilocybin effects seem to be lessened by food ingestion. Whenever I found myself tripping too hard, I did that even though food was the least of my interests. Alcohol never seems to touch it, nor do minor tranquilizers. Ice water might work.

I read that Narcan is used by paramedics in DXM OD situations, but I don't know if that's true. It doesn't seem like it would be helpful because Narcan is used for opiate overdoses.
 
Most people that do MDMA in conjunction with psychedelics experience a potentiation, not a diminished trip.

Short and fast acting benzo's are the preferred substances to use.
 
Great post atara, some most handy information. I have a basic grasp on that stuff, but that post for sure laid out some education.
 
slowpoke1967 said:
in my vast experience i have taken everything i can get my hands on and even gotten so pissed that i couldnt hold my head off the table at the bar and thought i was iether gonna pass out or puke ,,,,,physicidelics overload everything.period..like acid at least good acid will defete any drug...
one minute yer fucked up then an hour later yer trippin ...i dont care what you take cid will overtake all....ride it out ...
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I got really drunk years ago before a friend's wedding and had to drop some acid so I could do my maid of honor duties. Sobered me right up.
 
penpal said:
shall i confrim that phenazepam does indeed alot to halt the trip, i tested it out to day. after taking 5meodalt(tryptamine) i took .5-1.5mg of the phenz and it almost seemed like it stoped the trip completely, but then again 5meodalt is on the weaker side of the psychedelic spectrum.
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What is phenazepam? Sounds like a benzo. Not available in the US perhaps?
 
penpal said:
you got drunk then took acid to sober you up?
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Yup, this was many, many years ago. I don't drink anymore.

I was in 2-1/2" heels and never wear high heels. I have no idea how to walk in them when sober. I'm sure the wedding video is hilarious. 8)
 
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Stimulants do not help on a scary trip

Jblazingphoenix100 said:
Stims - baaaaaad what are you TALKING about people?!?! They make the trip way more hectic.
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No kidding! LSD used to contain a good portion of amphetamine, making it a very speedy drug. I prefer calmer trips, personally.

Quantum_Think, if you're joking, it's hard to see the tongue in your cheek. An emoticon might be helpful. Maybe you have ADD?

If you're just being cruel, that's a different and more disturbing matter.
 
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i heard many times from friends that stimuls or dopaminergetic drugs particulary coke tend to diminish substantially mind fuck still mantling some visual aspect of trips. i only tried one time with bk-pmma (methedrone) and halted to a certain degree but gave me big time anxiety. me and my friends use to call benzos, trip insurance, any trip we go with benzos, popping some or a lot can make a trip manageable or end it (knock out).
 
I've notice(much to the contrary of what I was expecting) that when I take mdai on 2ci, I don't trip AT ALL. I'm not sure it goes for all psychedelics, or maybe even the orderof which drugs you take, but the other day I had about 150mg mdai than about a hour later had 10mg 2ci, and later onto the day I ended up taking over 30mg of 2ci and did not trip one bit(I was also redosing on the mdai). And I know that it's not bunk 2ci I had, because I tripped balls on it solo on a separate occasion from the same batch. ..good times, I wish I hadnt plowed through my stash:/
 
LSD used to contain a good portion of amphetamine, making it a very speedy drug
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This is neither true nor logically possible. :p
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Has anyone had success using mirtazapine for such purposes? It antagonizes 5ht2a, but without spectacular binding affinity, IIRC.

ebola
 
Are there actually accounts reporting success with niacin and LSD? I know it was in some research paper, but it would be convincing if it could be reproduced (which is true for every scientific claim, obviously).

If it works I wonder about picamilon which is a condensed form of niacin and GABA. That might be even better for the purpose.
 
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