ok so iv been taking tramadol (i know not much of a PK) for like 4 months in a row and i could definitly tell that when i take it im a lot more social and just more happy in general and im gonna stop myself from taking them but im afraid ill just be miserable
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BDD Moderators: Keif’ Richards
Im afraid I wont be fun to be around if I dont take pain killers
- Thread starter scott5809
- Start date
Whats your dosage been? Coming off tramadol cold turkey might be a bad idea, you might want to taper. I hear it has some serious withdrawal, brain zaps and such.
^ agreed with that. its not like withdrawing off other opiates in some ways.
yea its possible you might not be fun. maybe drink a little instead (dont turn into an alcoholic..) when you need to be sociable. youre gonna have to detox eventually why not now when its only been 4 months?
yea its possible you might not be fun. maybe drink a little instead (dont turn into an alcoholic..) when you need to be sociable. youre gonna have to detox eventually why not now when its only been 4 months?
If he just goes cold turkey, isn't it possible for him to have a grand maul seizure?
Seriously bro, tapering would be a good idea, just to be on the safe side.
Starshowers
Bluelighter
Unfortunately there's no quick fix for change of personality coming off a drug that helps you socially. All I can recommend is do some psychedelics and think about the issue... with time this can be very helpful (spirituality).
Every night for 4 consecutive months? If your looking to quit, than I would taper.. Spread it out for acouple weeks. I'm sure you'll still have slight withdrawals, but it's better than what it would be. the SSRI effects are nothing to fuck around with.
definitely taper man. ive never been addicted but ive read some horror stories. its somewhat like benzos... you gotta have a good taper schedule and it'll be okay but if you miss a day or two it could get real bad real quick.
that dose isnt incredibly high but still enough to have some potential really bad effects coming with the WDs
that dose isnt incredibly high but still enough to have some potential really bad effects coming with the WDs
K'd-OUT-in-AZ
Bluelighter
No, it is not posible to suffer seizures from Tramadol. That only happens with drugs that effect the GABA receptors.
But it is best to taper. Although you've only been taking 100mg so taper shouldn't be long. Go down to 50mg then two weeks later go down to 25mg and then two weeks later get off it. You should suffer some minor withdrawals. Nothing like the non synthetic opiates. Although some say they feel just as bad, you shouldn't have as hard a time coming off only 100mg.
And to whomever said its sort of like benzos, no it is nothing like benzo withdrawal in any way and taper doesn't have to be so slow.
Don't the withdrawals from both cause brain zaps? They both have SSRI properties, so in a way, wont they be similar in some aspects? I know benzo w/d can be really fucked up, but I would assume that they could be somewhat similar.
OP should UTSE and find some of these posts I've read in the past month about tram withdrawal, get a feel for what he might be in for.
K'd-OUT-in-AZ
Bluelighter
No, benzodiazepines DON'T have SSRI properties. They are not similar whatsoever. Benzodiazepines is mostly muscle pains, opiates are sickness/flu. Benzodiazepine withdrawal doesn't cause brain zaps. And Tramadol is an SNRI.
Misinformation is not what I was aiming for
psychomimetic
Bluelighter
Tramadol can cause seizures, but I don't think withdrawing from it can.
From what I've heard, tramadol withdrawals are very bad because of the SSRI and SNRI properties of tramadol. Brain zaps and other unique effects that don't occur with other opiates (generally) can happen.
K'd-OUT-in-AZ
Bluelighter
Its all good.
K'd-OUT-in-AZ
Bluelighter
No, Tramadol causes seizures in too high of a dose, not from withdrawaling. But I think that is what you were trying to get at.
xxRavenxx
Bluelighter
I totally agree with this!
INCORRECT Tramadol CAN cause Seizures in withdrawal
AND Tramadol is a slight GABA AnTAGONIST so it does effect the Gaba system in a roundabout way
Tramadol acts as a μ-opioid receptor agonist,[51][52] serotonin releasing agent,[6][7][8][9] norepinephrine reuptake inhibitor,[52] NMDA receptor antagonist,[53] 5-HT2C receptor antagonist,[54] (α7)5 nicotinic acetylcholine receptor antagonist,[55] and M1 and M3 muscarinic acetylcholine receptor antagonist.[56][57]
The analgesic action of tramadol has yet to be fully understood, but it is believed to work through modulation of serotonin and norepinephrine in addition to its mild agonism of the μ-opioid receptor. The contribution of non-opioid activity is demonstrated by the fact that the analgesic effect of tramadol is not fully antagonised by the μ-opioid receptor antagonist naloxone.
Tramadol is marketed as a racemic mixture of the (1R,2R)- and (1S,2S)-enantiomers with a weak affinity for the μ-opioid receptor (approximately 1/6000th that of morphine; Gutstein & Akil, 2006). The (1R,2R)-(+)-enantiomer is approximately four times more potent than the (1S,2S)-(–)-enantiomer in terms of μ-opioid receptor affinity and 5-HT reuptake, whereas the (1S,2S)-(–)-enantiomer is responsible for noradrenaline reuptake effects (Shipton, 2000). These actions appear to produce a synergistic analgesic effect, with (1R,2R)-(+)-tramadol exhibiting 10-fold higher analgesic activity than (1S,2S)-(–)-tramadol (Goeringer et al., 1997).
The serotonergic-modulating properties of tramadol give tramadol the potential to interact with other serotonergic agents. There is an increased risk of serotonin toxicity when tramadol is taken in combination with serotonin reuptake inhibitors (e.g., SSRIs) or with use of a light box[citation needed], since these agents not only potentiate the effect of 5-HT but also inhibit tramadol metabolism.[citation needed] Tramadol is also thought to have some NMDA antagonistic effects, which has given it a potential application in neuropathic pain states.
Tramadol has inhibitory actions on the 5-HT2C receptor. Antagonism of 5-HT2C could be partially responsible for tramadol's reducing effect on depressive and obsessive-compulsive symptoms in patients with pain and co-morbid neurological illnesses.[58] 5-HT2C blockade may also account for its lowering of the seizure threshold, as 5-HT2C knockout mice display significantly increased vulnerability to epileptic seizures, sometimes resulting in spontaneous death. However, the reduction of seizure threshold could be attributed to tramadol's putative inhibition of GABA-A receptors at high doses.[53]
thanks guys i appreciate all the input but I have another question, its been 3 or 4 days since i had my last 100mg dose and after the first night of not taking it I got pretty sick i thought i had a sinus infection but iv been reading the WD have flu like symptoms so idk if im sick or going thru WD lol i was pretty sick yesterday but then last night i took 1 tram to kinda wean myself off it and i felt not fully better but a lot better than i felt the past couple days and when i woke up this morning my nose wasnt even stuffed anymore but im still coughing at times...it just feels too much like an actual cold to be WD but i could be wrong
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