somedud
Bluelighter
Hello everyone, this if the first time i've posted in this ADD section. This is my situation, and hopefully a possbile resolution to a brutal depression i'm going through. Appx 4-5 months ago I finished a 4 month binge of MDMA upon which I used about once a week. Before this recent binge, i've probably used 40-50 times in 3 years, appx 300-500 pills in total, once up to 9 in one night.
My abuse has resulted in me dropping out of univtersity, losing my edge, becoming a social recluse (opposed to being the most social person you've ever met), and I feel extremelyyyy dumb. To the point where I can't remember what I did two hours previous, and literally can not hold a basic conversation.
My question, since this is ADD and I assume theres some pretty intellectual people in here on these topics, do you believe that an ECT therapy followed by a Neurofeedback therapy to oppose any cogntive declines (memory) from ECT, would be a possbile escape from this crippling depression, in hopes to not **** my brain up too much to return to school? i.e think this is a danagerous/risky approach?
Studies to back the theory of sprouting of new serotogenic axons (which is, to what I believe, to be the main reason depression (which persists for months/years [not weeks] occurs with those who have abused MDMA.
"Abstract
Depression in former ecstasy users may not respond to selective serotonin reuptake inhibitors (SSRIs) possibly due to damaged serotonergic synapses following long-term heavy ecstasy use. We report findings in a patient suffering from MDMA-induced depression which was refractory to several antidepressive medications including selective noradrenergic reuptake inhibitor (SNRI) and SSRI. An add-on repeated bilateral electroconvulsive therapy (ECT) was able to achieve a stable remission of affective and cognitive symptoms with a follow-up of more than 1.5 years. Add-on ECT could be a treatment option in former ecstasy users with severe depressive disorders that fail to respond to SSRI and/or SNRI. Clinical trials are needed to evaluate further the usefulness of ECT in this patient group. "
and
"University of Dundee, Department of Psychiatry, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK
Accepted 28 November 2000. Available online 19 February 2001.
Abstract
Electroconvulsive stimulation (ECS) has been shown recently to induce axonal sprouting of granule cells in the rodent hippocampus. This may relate to the clinical efficacy of electroconvulsive therapy (ECT) in humans. We compared the effects of three different clinically effective antidepressant treatments on mossy fibre sprouting in the rat dentate gyrus using Timm’s histochemistry: (1) repeated spaced ECS; (2) daily administration for 4 weeks of the serotonin re-uptake inhibitor fluoxetine (1 mg/kg); and (3) daily administration for 4 weeks of the noradrenaline re-uptake inhibitor desipramine (5 mg/kg). The effect of subconvulsive electrical stimulation was also examined. Repeated ECS-induced sprouting while subconvulsive stimulation (which is ineffective clinically) did not. The two well-established chemical antidepressant therapies were also ineffective, indicating that induction of mossy fibre sprouting is not a common property of effective antidepressant agents. It is possible that the ability to induce sprouting might relate to the superior efficacy of ECT when compared to chemical antidepressants in clinical practice. Alternatively, it may contribute to the transient cognitive impairment that accompanies ECS in humans and other species."
My abuse has resulted in me dropping out of univtersity, losing my edge, becoming a social recluse (opposed to being the most social person you've ever met), and I feel extremelyyyy dumb. To the point where I can't remember what I did two hours previous, and literally can not hold a basic conversation.
My question, since this is ADD and I assume theres some pretty intellectual people in here on these topics, do you believe that an ECT therapy followed by a Neurofeedback therapy to oppose any cogntive declines (memory) from ECT, would be a possbile escape from this crippling depression, in hopes to not **** my brain up too much to return to school? i.e think this is a danagerous/risky approach?
Studies to back the theory of sprouting of new serotogenic axons (which is, to what I believe, to be the main reason depression (which persists for months/years [not weeks] occurs with those who have abused MDMA.
"Abstract
Depression in former ecstasy users may not respond to selective serotonin reuptake inhibitors (SSRIs) possibly due to damaged serotonergic synapses following long-term heavy ecstasy use. We report findings in a patient suffering from MDMA-induced depression which was refractory to several antidepressive medications including selective noradrenergic reuptake inhibitor (SNRI) and SSRI. An add-on repeated bilateral electroconvulsive therapy (ECT) was able to achieve a stable remission of affective and cognitive symptoms with a follow-up of more than 1.5 years. Add-on ECT could be a treatment option in former ecstasy users with severe depressive disorders that fail to respond to SSRI and/or SNRI. Clinical trials are needed to evaluate further the usefulness of ECT in this patient group. "
and
"University of Dundee, Department of Psychiatry, Ninewells Hospital & Medical School, Dundee DD1 9SY, UK
Accepted 28 November 2000. Available online 19 February 2001.
Abstract
Electroconvulsive stimulation (ECS) has been shown recently to induce axonal sprouting of granule cells in the rodent hippocampus. This may relate to the clinical efficacy of electroconvulsive therapy (ECT) in humans. We compared the effects of three different clinically effective antidepressant treatments on mossy fibre sprouting in the rat dentate gyrus using Timm’s histochemistry: (1) repeated spaced ECS; (2) daily administration for 4 weeks of the serotonin re-uptake inhibitor fluoxetine (1 mg/kg); and (3) daily administration for 4 weeks of the noradrenaline re-uptake inhibitor desipramine (5 mg/kg). The effect of subconvulsive electrical stimulation was also examined. Repeated ECS-induced sprouting while subconvulsive stimulation (which is ineffective clinically) did not. The two well-established chemical antidepressant therapies were also ineffective, indicating that induction of mossy fibre sprouting is not a common property of effective antidepressant agents. It is possible that the ability to induce sprouting might relate to the superior efficacy of ECT when compared to chemical antidepressants in clinical practice. Alternatively, it may contribute to the transient cognitive impairment that accompanies ECS in humans and other species."
