Cocaine vaccine could make drug addiction a distant memory

spini4

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The first ever vaccine for drug addiction has just been created. By combining a cocaine-like molecule with part of the common cold virus, you get a vaccine that turns the immune system against cocaine, keeping it away from the brain.

So far, the vaccine has only been tested on mice, but the results are extraordinary. Mice given the vaccine no longer exhibited any of the hyperactive signs of a cocaine high when they were next given the drug. The vaccine was created by taking just the part of the cold virus that alerts the body's immune system to its presence, and then researchers connected the signalling mechanism to a more stable version of the cocaine molecule.

Once the mice received an injection of the vaccine, they started producing anti-cocaine antibodies which targeted and destroyed any cocaine that then entered their system. Normally, cocaine does not produce an immune response, leaving it free to wreak havoc on the brain and body of whoever takes it. But the cold virus segments taught the immune system to treat cocaine like a hostile invader, offering a nearly impregnable wall of protection from the cocaine's effects.

Researcher Ronald Crystal explains what this means:

"Our very dramatic data shows that we can protect mice against the effects of cocaine, and we think this approach could be very promising in fighting addiction in humans. While other attempts at producing immunity against cocaine have been tried, this is the first that will likely not require multiple, expensive infusions, and that can move quickly into human trials. There is currently no FDA (Food and Drug Administration) approved vaccine for any drug addiction.The vaccine may help [drug addicts] kick the habit, because if they use cocaine, an immune response will destroy the drug before it reaches the brain's pleasure center.

read more at: http://io9.com/5725864/cocaine-vaccine-could-make-drug-addiction-a-distant-memory
 
just amazing...a cocaine molecule combined with the common cold but it very much makes perfect sense. This is very interesting and opens the door to a better treatment process for drug addiction. I now wonder whether they will continue to further in the production of other drug vaccines for different drugs.
 
which moiety of the cocaine structure are they including in the vaccine? I'd be worried that many other drugs would be rendered useless. Benztropine (Cogentin) for instance maybe.

Look: there's no way to deactivate some vaccines. Tropanes are the subject of extensive pharmaceutical research. Who knows if a fantastic drug for horrible disease X is not on the horizon and happens to include the targeted moiety?
 
That seems like a really screwed up solution. Do we have any molecules in our body structurally similar to cocaine that could cause an immune response?
 
Idk, it sounds a lot like naloxone only for cocaine. And most people I know think things like naloxone that just blocks the effects of a drug are kind of terrible addiction aids and don't actually help much, since they don't help with most of the actual addiction itself...

Then again I'm saying this assuming that this vaccine doesn't actually help curb cravings, but if it did it would be a lot more like bupenorphine only for cocaine, which would be great on the other hand, but I don't see how just making one's immune system attack cocaine would help with cravings at all.
 
I don't know anything about the pharmacology of cocaine specifically, but I do know that I'm really, really not a fan of the effects that cocaine use has on people (even in responsible moderation ... someone who makes sure never to get addicted to coke still kinda acts like a dick when they're on it, in my experience), and I think it's a potentially extremely good thing to have this "vaccine" available to people. I'm not sure what its best application might be but it seems like it at least has potential.
 
it's nothing like naloxone. It would make the body produce cocaine antibodies, so that the immune system would treat cocaine as an infection.

how long would the vaccine be active for?

presumably for life. The cocaine molecule is not gonna mutate like viruses or bacteria do.
 
could you imagine... for every newborn child being mandatory to take this vaccine this could be the start of the end of cocaine
 
^ That's more along the lines that I was thinking, giving this to children to prevent addiction in the future, not necessarily cure a current addict.

It would be awesome if they could use this same technique for opiates, but seeing on how many legitimate medications contain those same molecules, I don't think it would ever pass.
 
babies and bathwater

* AC-262,356
* Altropane
* Anisodamine
* Anisodine
* BIMU8
* Bemesetron
* Benzatropine
* Benzoylecgonine
* Brasofensine
* CAR-226,086
* Cimetropium bromide
* Clobenztropine
* Cocaethylene
* Deptropine
* Dichloropane
* Difluoropine
* Ecgonidine
* Etybenzatropine
* Fentonium
* 3-(p-Fluorobenzoyloxy)tropane
* 4'-Fluorococaine
* N-(2'-Fluoroethyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane
* N-(3'-Fluoropropyl-)-3β-(4'-chlorophenyl)-2β-(3'-phenylisoxazol-5'-yl)nortropane
* Granisetron
* Homatropine
* Ioflupane (123I)
* Ipratropium
* Maraviroc
* Methscopolamine
* Methylatropine
* Methylecgonidine
* (-)-2β-(3-(4-Methylphenyl)isoxazol-5-yl)-3β-(4-chlorophenyl)tropane
* Methylscopolamine
* NS-2359
* Norcocaine
* Octatropine methylbromide
* (-)-2β-(1,2,4-Oxadiazol-5-methyl)-3β-phenyltropane
* Phenyltropane
* 2α-(Propanoyl)-3β-(2-(6-methoxynaphthyl))-tropane
* 2-Propanoyl-3-(4-isopropylphenyl)-tropane
* 2β-Propanoyl-3β-(2-naphthyl)-tropane
* 2β-Propanoyl-3β-(4-tolyl)-tropane
* RTI-112
* RTI-113
* RTI-121
* RTI-150
* RTI-177
* RTI-274
* RTI-31
* RTI-32
* RTI-352
* RTI-353
* RTI-371
* RTI-55
* RWJ-394674
* Ricasetron
* RTI-229
* RTI-51
* Salicylmethylecgonine
* Tesofensine
* Troparil
* Tropatepine
* Tropine
* Tropinone
* Tropisetron
* Tropoxane
* WIN 35428
* Zatosetron
 
I would say those are a list of tropines and cocaine analogs/homologues and similar compunds that may be beneficial for a human as a drug treatment regiment which could be adversely affected by this so called vaccine. Then there's the 1984 Orwellian aspect, whereas the UN has already admitted cataloging every newborn baby's DNA in a database SINCE 1984, but also the idea that you are no longer trusted WITH YOUR GOD GIVEN BODY to make natural decisions over what to ingest with your body.... am I making sense here folks?? This is a communist/Nazi/Socialist?marxist scheme, if I ever heard one. BTW, Karl Marx's kids starved whilst he wrote the Communist Manifesto.. which this arizona shooter "LOEHNER" was a fan of.. along with Mein Kampf.. this is where this line of thinking eventuallly leads a society, not a pretty sight whatsoever.
 
Im all for anything to help someone to kick a coke addiction i just hope that they don't start giving this shit as a regular vaccine that you get as a kid. I believe it's a persons choice to take drugs or not and the government should have no say in it.

Also havent there been vaccines like this tried before but they didnt make it to market for one reason or another?
 
I think that there is a greater chance that they would force people who had been arrested / convicted for cocaine possession to take the vaccine than every child born.
Still sounds very Orwellian to me. Or like Clockwork Orange.
Taking away our free will "for the good of society".

For those of you who are supporting the idea (Brutal Roller), I must say that I feel sick at the thought.
You don't like cocaine, so you support the idea of forced mandatory vaccination.
Watch out, a majority in your country might support some other vaccination for the types of consciousness you enjoy.
 
I think that there is a greater chance that they would force people who had been arrested / convicted for cocaine possession to take the vaccine than every child born.
Still sounds very Orwellian to me. Or like Clockwork Orange.
Taking away our free will "for the good of society".

For those of you who are supporting the idea (Brutal Roller), I must say that I feel sick at the thought.
You don't like cocaine, so you support the idea of forced mandatory vaccination.
Watch out, a majority in your country might support some other vaccination for the types of consciousness you enjoy.
 
It sounds like Orwells nightmare coming true. Taking away a persons free will in the name of making society better is totaltarian for sure. I can imagine them forcing people who have been convicted for drug offences to take this vaccine and any drug user who says oh i hate cocaine and it's a shit drug so this is a good idea is very hypocritical in my opinion. What if they come up with a vaccine for say cannabinoids or opioids? Remember if you tolerate this then you could very well be next.
 
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