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'Antidotes' for OD situations.

Transform

Transform

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So we know that Naloxone is able to completely reverse an opiate overdose in a matter of minutes.
Why aren't there similar antidotes for other recreational drugs?


We know that benzos are fairly effective at helping with a psychedelic overdose, and as far as I'm aware they can also be used for stim overdoses.
How come we don't have full antagonists widely available for these drugs? Is it because the risk of death from overdose is low, so health companies won't pay for something which will just treat someone having a bad time?
 
Depending on the drug administered, using an antagonist can make things worse because the antagonist could have activity at other sites that the drug is hitting. This is especially true in the case of research chemicals. When I OD'd on 5-MeO-AMT, the only thing they could think to give me was four injections of Ativan because they didn't know the receptor profile of 5-MeO-AMT.

I took mirtazapine one time on aMT thinking its 5-HT2a antagonism would slow the trip down and through some interaction, it actually made the trip worse.

Also, look at the seizure risk when a hardcore benzo addict OD's on benzos and is given flumazenil for another example.
 
Surely if it antagonises all sites the drug is binding at, then that's good.

For the heavy users, it's just instantly precipitating WD symptoms, it tends to be inexperienced users who make these mistakes?
 
i've found zyprexa (atypical antipsychotic) stops any psychedelic experience dead in its tracks with no side effects other that sedation. Benzos just seem to take the edge off. I imagine it would work for stimulants to because it is an antagonist at many dopamine receptors too.
 
I've never tried to stop aMT or 5-meo-aMT but it definitely works for mushrooms, lsd, 2c-p, 2c-b, 2c-t7, 2c-e, and 5-meo-DIPT. How much did you try for (5-Meo-)aMT? I would think at the least it would knock you the fuck out.
 
I don't know the size of the pills but they gave me three of them at the hospital for 5-MeO-aMT and they didn't do shit - the ativan injections are what saved me. A friend of mine gave me one when I took way too much degraded aMT and it didn't do anything but the 200mg of Seroquel she gave me later sure did.

Its possible I just have an immunity to Zyprexa. It wouldn't surprise me if Olanzapine has a cross-tolerance with benzodiazepines and at the time I was on up to 8.5mg a day of Xanax.
 
you must have an immunity because even 10 mgs of zyprexa will put most people in pretty much a coma for 30 hours. and i think the weakest pills are 2.5mg. the ones i've seen have been 10mg. i've found you only need 1-2 mg to abort even a full on complete flip out trip. i'm surprised the seroquel did anything to you considering the zyprexa didn't. they are pretty similar but zyprexa is a stronger 5-ht2a antagonist IIRC.
 
Looking here - http://www.drugs.com/imprints.php?action=search&drugname=zyprexa they gave me a 15mg pill when I was on aMT and the hospital gave me 3 5mg pills. I must have a pretty serious natural tolerance to that drug then.

They gave me a 10mg twice when I went to the hospital with alcohol poisoning and suicidal ideation and it didn't do anything. My body is just weird. It really doesn't like drugs. Especially anti-psychotics. I guess my brain likes 5-HT2a to be freely agonized LOL!
 
"Also, look at the seizure risk when a hardcore benzo addict OD's on benzos and is given flumazenil for another example."

Yes but for an occasional benzo user who had combo od'd with benzos and heroin, naloxone and flumazenil could save their life, then the benzo is just holding the person still unconscious, another reason why its important medical personal have a 100% conplete list of drugs the person is on..
 
Benzos > Antipsychotics for treating psychedelic overdoses. The hospital is also most likely playing it safe since lorazepam/diazepam injection has a well-known side effect and dosage profile and they know it will take the edge off without giving you all the heavy side effects of hardcore antipsychotics.

I've read that, at least for some people, using atypical antipsychotics to treat tryptamine overdoses actually made the experience worse. Don't quote me on that, however.

I have used Seroquel to stop bad LSD experiences dead in their tracks.
 
NeighborhoodThreat said:
I've read that, at least for some people, using atypical antipsychotics to treat tryptamine overdoses actually made the experience worse. Don't quote me on that, however.
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I was under the impression that this was the case for typical antipsychotics moreso than the atypicals... although it could be a risk with both. I would assume its more prevalent with older drugs such as chlorpromazine and haloperidol though. The typicals don't usually a high affinity for 5-HT2 do they?

"Thorazine and other major tranquillizers are not specific neutralizers of the LSD effect. Used in high dosages, they have a general inhibiting effect that overrides and masks the psychedelic action of LSD. Detailed retrospective analysis of this situation usually shows that the patient experiences the action of both drugs simultaneously, and that the combined effect is rather unpleasant."

Stan Grof, LSD Psychotherapy - quoted in Erowid's Psychedelic Crisis FAQ.
 
atara said:
Those are monoamine releasers; different pharmacology. AMT in particular is as much a serotonin releaser as a serotonergic agonist.
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I knew that AMT is a monoamine releaser but 5-MeO-AMT? I understood the pharmacology of 5-MeO-AMT to be the fact that it is essentially serotonin that has been modified so it passes the BBB and thus agonizes a lot of 5HT subtypes, which was responsible for its extremely long-lived effects and its extreme toxic response?

Is there any known viable antagonist for AMT? I ask because while its one of my favorite drugs, it is very dose sensitive for me and lower doses feel like pure speed and cause massive tachycardia and hypertension for me but higher doses do not seem to have that effect unless I take TOO much. 50mg of decent quality AMT is a good dose for me to have a full psychedelic experience without the nasty speedy quality but going higher than that or lower than that, the speedy quality manifests itself.

I've heard that trazodone is quite effective for canceling out AMT's effects but trazodone puts me into such a deep sleep that I get stuck in a cycle of thinking I'm awake and walking around but I'm still sleeping and when I finally wake up, its a huge shock to my system almost like I wasn't breathing.

I also don't get why benzodiazepines do not appear to work with AMT but yet they work with heavier monoamine releasers such as 4-MMC, MDMA, MDA, amphetamine, etc. Unless I'm wrong I'm pretty sure AMT is not as potent a monoamine releaser as either MDMA or 4-MMC.
 
^ For most, benzos don't even work for anxiety and panic from cannabis so I fail to see how this would change for synthetic cannabinoids. The last time I had a pot-induced panic attack, xanax made it MUCH worse in fact.
 
Ask FnB about the details ... if he didn't left just recently.

Somebody here at Bluelight stated once:
CB1 receptors are thought to be the most widely expressed G protein-coupled receptors in the brain. This is key to endocannabinoid-mediated depolarization-induced suppression of inhibition, a very common form of short-term plasticity in which the depolarization of a single neuron induces a reduction in GABA-mediated neurotransmission. Endocannabinoids released from the depolarized neuron bind to CB1 receptors in the pre-synaptic neuron and cause a reduction in GABA release.
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(don't remember who said this; no source given either)

But assuming that the quotation is correct, GABA-agonist would indeed make sense in a cannabinoid-overdose scenario. Just because it didn't work in you doesn't mean that the concept is ruled out in general!
 
MagickalKat777 said:
^ For most, benzos don't even work for anxiety and panic from cannabis so I fail to see how this would change for synthetic cannabinoids. The last time I had a pot-induced panic attack, xanax made it MUCH worse in fact.
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yeah but you seem to report a lot of incidents where drugs didn't work for you that clearly have for others. either you are different (very possible) or you're talking nonsense, who knows really?:D

xanax for me made speed feel like mdma in terms of euphoric relaxation and loved upness. i would imagine that benzo's work well for other stim abuse comedown situations (they are great for coming down from coke). zoplicone was a godsend for me after a methylone binge, same after using mdma and amt, also it was great for coming down from mdpv.

all in all benzo's/zdrugs are essential if you have overdone hard stimulants
 
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