socio
Bluelighter
- Joined
- Dec 14, 2009
- Messages
- 342
Lemon Juice inhibits CYP450 enzymes almost as well as Grapefruit -------------------------------------------------------------------------------
(Sorry, no intent to double-post, but methinks this belongs here. PM me to request I remove anything redundant with other posts.)
http://www.ncbi.nlm.nih.gov/pubmed/18968322
Lemon juice, like Grapefruit Juice, Cimetidine, and other substances, potentiates by inhibiting one or more of the CYP450 liver enzymes responsible for metabolism of opioids.
Star Fruit, too, among others. Useful to check specific fruits, esp. citrus, since many have some degree of inhibition.
Here is a table showing selected CYP450 substrates, inhibitors (i.e., potentiators), and inducers. Broken down by specific enzyme (e.g., 3A4 & 2D6, those most responsible for opioid metabolism; inhibiting them is good for opis):
See also:
(Sorry, no intent to double-post, but methinks this belongs here. PM me to request I remove anything redundant with other posts.)
http://www.ncbi.nlm.nih.gov/pubmed/18968322
Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice.
Baltes MR, Dubois JG, Hanocq M. Talanta. 2001 Jun 21;54(5):983-7.
Abstract
... Grapefruit juice is a well-known potent inhibitor of cytochrome P450 3A4 activity. With regard to the clinical relevance of grapefruit juice-drug interactions, an investigation of other common juices is undertaken with this in vitro model.... It is demonstrated for the first time that lemon juice significantly inhibits by 60+/-3% the CYP3A4-mediated oxidation. Grapefruit juice inhibits this activity by 82+/-4%. The mechanism of lemon juice inhibition is competitive, whereas it is mixed for grapefruit juice. ...
Lemon juice -- better, lemonade -- works almost as well as grapefruit juice at potentiating almost any opioid. (This does not apply to codeine, which works by being metabolized into morphine. Others?)Baltes MR, Dubois JG, Hanocq M. Talanta. 2001 Jun 21;54(5):983-7.
Abstract
... Grapefruit juice is a well-known potent inhibitor of cytochrome P450 3A4 activity. With regard to the clinical relevance of grapefruit juice-drug interactions, an investigation of other common juices is undertaken with this in vitro model.... It is demonstrated for the first time that lemon juice significantly inhibits by 60+/-3% the CYP3A4-mediated oxidation. Grapefruit juice inhibits this activity by 82+/-4%. The mechanism of lemon juice inhibition is competitive, whereas it is mixed for grapefruit juice. ...
Lemon juice, like Grapefruit Juice, Cimetidine, and other substances, potentiates by inhibiting one or more of the CYP450 liver enzymes responsible for metabolism of opioids.
Star Fruit, too, among others. Useful to check specific fruits, esp. citrus, since many have some degree of inhibition.
Here is a table showing selected CYP450 substrates, inhibitors (i.e., potentiators), and inducers. Broken down by specific enzyme (e.g., 3A4 & 2D6, those most responsible for opioid metabolism; inhibiting them is good for opis):
See also:
http://www.edhayes.com/CYP450-3.html
http://www.aafp.org/afp/2007/0801/p391.html [TABLE 1, TABLE 2]
http://www.aafp.org/afp/2007/0801/p391.html [TABLE 1, TABLE 2]