Amphetamine's mesolimbic action

[Nexus298]

I was reading the wiki on Adderall and it states that Amphetamine works on the mesolimbic pathways. Is this true? If so how come Amphetamine doesn't have the same addiction potential as Cocaine? I want to say it has to do with serotonin being released in conjunction with the dopamine. (Methamphetamine)
Also if anyone could name a few more compounds that act on the Mesolimbic system.

 

[rickolasnice]

^ More intense release of dopamine and a much shorter duration.. ?

 

[ziddy]

Amphetamine DOES have a high addiction potential. It's just that the intended, therapeutic use is of low doses taken orally. Have someone without much tolerance snort 60mg and you'll see what I mean...

 

[Nexus298]

I used to be addicted very much so to crack and I take Dexedrine everyday but have absolutely no addiction to them. I am almost the opposite, I hate taking them and only do so when I have to because of narcolepsy/excessive day time sleepiness. I don't see how the mechanism of addiction for Cocaine is the mesolimbic system. If Amphetamines works on this as well how come the same addiction potential isn't there?

 

[Mudeltakappa]

If Amphetamines works on this as well how come the same addiction potential isn't there?

It IS there.

That's why, you know, millions of people are addicted to amphetamines.

Also if anyone could name a few more compounds that act on the Mesolimbic system.

Most addictive drugs, whether directly or indirectly, cause increased dopamine activity in the nucleus accumbens (part of the mesolimbic system). So, cocaine, amphetamines, opiates/opioids, alcohol, nicotine, etc... even caffeine to a certain extent.

 

[pofacedhoe]

both amphetamine and cocaine are very addictive