4-aco-DMT and MAOIs (syrian rue?)

[paigethylamine]

This is in regards to a post I previously made about high doses of 4-aco-dmt, and it just occured to me that the effects I desire (such as the ones I got from ayahuasca) may have been the result of potentiation. Has anybody given any thought to this or have any experiences? I've used syrian rue with mushrooms before but never this particular chemical....

 

[mi5]

Not tried this yet but its on my to-rue list.

 

[Bardeaux]

I've used 4-Aco-DMT with Caapi before and it was the best 4-Aco-DMT experience I've had. If I had a large supply of maoi I would never take psilacetin without it again.

 

[carbon unit]

http://dmtdrug.com/maoi.htm

some interesting info..

and how about passionflower? Easily available at least.

 

[mi5]

I've used 4-Aco-DMT with Caapi before and it was the best 4-Aco-DMT experience I've had. If I had a large supply of maoi I would never take psilacetin without it again.

really?

would you mind describing the differences for us, I am very interested.

 

[Bardeaux]

It felt more dmt-like than anything else I've tried, much more so than 4-Aco-DMT by itself in my experience. Although the 4-Aco-DMT can be very deep on it's own, coupled with an maoi it was extremely revelatory, about on par with my high(ish) dose mushroom experiences.

I never seem to get visuals from it by itself either, even at high doses. But they were pretty pronounced with an maoi.

 

[paigethylamine]

It felt more dmt-like than anything else I've tried, much more so than 4-Aco-DMT by itself in my experience. Although the 4-Aco-DMT can be very deep on it's own, coupled with an maoi it was extremely revelatory, about on par with my high(ish) dose mushroom experiences.

I never seem to get visuals from it by itself either, even at high doses. But they were pretty pronounced with an maoi.

4-aco-DMT felt very DMT like for me as well; I can't really imagine how the metabolism of this chemical into psilocin could be based off experience based on what I experienced but somebody on my other thread mentioned that it's likely that because everybody's metabolism is different it could lean either way (ie: more like shrooms or more like DMT.)

I suspect that even if it does metabolize into psilocin which this is an assertion I would not question for a second (lot's of really smart people believe this to be true) that based on what I've read it does stand to be active fairly on it's own (before it's metabolized into anything else.)

It would be cool to understand whether this assertion is based on a cytochrome (p450?) study of it's metabolism (if that's even possible I'm such a noob so I'm only trying to put this together) or if it's based on the person's experience though.

 

[abore]

I'm really interested in some experiences people have had with this combo. Does it make the length much longer because one of my favorite things about this substance is its short, convenient duration.

 

[paigethylamine]

http://dmtdrug.com/maoi.htm

some interesting info..

and how about passionflower? Easily available at least.

This is good information, also I thought I might merely point out the following information that I determined from reading that article:

http://en.wikipedia.org/wiki/Reversible_inhibitor_of_monoamine_oxidase_A

A list of irreversible MAOIs:

http://en.wikipedia.org/wiki/Special:Search/Irreversible_inhibitor_of_monoamine_oxidase_A

I think I'll still be just as careful with MAOIS. Also there are some interesting assertions about dangerous combination that I think I'll want to investigate further. I've read articles about people consuming San Pedro cactus tea with Ayahuasca which has peganum harmala so it will be interesting to find out why that's a dangerous combination but not Mimosa Hostilis.

I can also say that in practice (with the assumption of it being safer) I have skipped doses of Zoloft on days that I planned to use MAOIs but without much advance (same stop day.) I'm not sure but it seems like the stuff wears off pretty quick anyway.

To be quite honest, with the exception that I consumed a piece of bread (which is apparently not as dangerous according to that article) I didn't have any negative side effects. The bread seemed to do something to me though that I didn't like. It felt like it POTENTIATED my come up. It was very buttery toast, and I'm sorry I feel really stupid and bad that I ate the toast but my stomach was unsettled and I wanted it to not be. I'll never do it again I promise but also I really hope my come up next time I drink the ayahuasca isn't any different because it was rad and I wouldn't want it to be any other way.

 

[paigethylamine]

I'm really interested in some experiences people have had with this combo. Does it make the length much longer because one of my favorite things about this substance is its short, convenient duration.

I'll try to experience this with less toast and food and I'll tell you about it if I can remember to tell you about it -- I'm sure I'll try it.

Also I wonder if the proteins in mushrooms such as cyanescens or cubensis can have an adverse reaction with an MAOI (such as harmine which is considered to be a lesser-dangerous reversible MAOI.)

 

[abore]

I'll try to experience this with less toast and food and I'll tell you about it if I can remember to tell you about it -- I'm sure I'll try it.

Also I wonder if the proteins in mushrooms such as cyanescens or cubensis can have an adverse reaction with an MAOI (such as harmine which is considered to be a lesser-dangerous reversible MAOI.)

Sounds great, I'd really appreciate it.

 

[TheAzo]

I've read articles about people consuming San Pedro cactus tea with Ayahuasca which has peganum harmala so it will be interesting to find out why that's a dangerous combination but not Mimosa Hostilis.

I'm just hypothecizing here, but, the cactii have a real witches brew of mescaline-like chemicals in them - substituted PEAs and related compounds. I wouldn't be surprised if some of them acted as weak DA/NE releasers/reuptake inhibitors, which would be dangerous in combination with an MAOI, yet not noticeable normally.