What makes Oxycodone so unpredictable ?

[Unlucky]

Oxycodone is an extremly finicky drug and my physical response to it often varies greatly and often I experience two very opposite reactions to it from day to day.

Most of you probaly wouldn't notice this because in you healthy individuals drug responses can be quite standard, but it usually takes a hypersensitive dude with a diagnosed damaged Autonomic Nervous System like myself to pick up on its tendency or the potential to cause reponses that fluctuate and opposite to what its known to do.

For me Oxycodone has the potential to do 3 things:

1- Sedative response. (for eg. nodding, sleepy, sedated, low blood pressure, low heart rate, dizzy, nauseated, slowed breathing- respiratory depression)

2- Neuro-excitory reponse. (for eg. alert, buzzing, feeling wired, insomnia, increased blood pressure, increased heart rate, confusion, fever-hyperthermia)

3- Both Sedative and Neuroexcitory reponse at the same time. (for eg. Nodding whilst feeling really alert at the same time, icy cold exteremeties with chills whilst feeling hot and feversih every where else, high blood pressure with a very low heart rate or hypertension followed by hypotension and vise- versa.

Oxycodone has mede me feel things I never thought was possible such as feeling two very oppsoite sensations simultaneously, something like feeling hot and cold at the exact same time or feeling very nauseated, sedated and sleepy whilst having a dangerously high blood pressure and headache.

Even though these reactions can be accounted due to my medical condition known as Dysautonomia which causes a hypersentivity to ANS acting substances I can still say that Morphine unlike Oxycodone is a lot more predictable and only causes a single sedative type response in me so its not just me, its also depends on the type of drug. Even after being on Oxy for 2 years I never know which of the 3 listed responses above its going to surprise me with on a random day.

So my question is what is the process behind Oxycodone's unpredicatable, day to day fluctuating and varying response ?

 

[Unlucky]

Do you find many other chemicals "finicky", or just oxycodone?

Thank you for your response but as I said my condition alone cannot account for this reaction because other class of drugs are not as unpredicatble as Oxycodone.

Sure I still experience some sort of adverse reactions and problems with all class of pyschoactives but often this reaction is more like a hypersensitivity where I react the same way to small dose as someone taking a larger dose for example my 50mg Tramadol side effect is equal to your 200mg response and this is the case for majority of the drugs out there.

I have not tried oxymorphone but I have tried dilaudid and that too was similar in its unpredictable reponse like Oxycodone where as fenntanyl, morphine, tramadol were a lot more stable even though they still made me sick due to the hypersensitivity but the ill response was the same everytime not fluctuating to the difference in vitals seen in Oxycodone.

 

[Sturnam]

Thank you for your response but as I said my condition alone cannot account for this reaction because other class of drugs are not as unpredicatble as Oxycodone.

I understand your desire for answers, but honestly, I don't think you will ever get any. You have a rare, poorly understood neurological disorder that greatly affects your reaction to many substances. If we don't know the exact pathology/biochemical consequences of your disorder, what makes you think anyone can predict why you react certain ways to certain drugs?

IMO, your best option is to get involved with research finding out the exact causes of Dysautonomia, and the associated pathology. The more we know about the causes/consequences of the disorder itself, the more we will be able to create drugs targeting it, and predict the outcome of other drugs.

I know you have had issues with people dismissing you in the past, so please don't think I am trying to do that. I'm just letting you know that getting an answer is impossible at this point, and any answers you will get are wild guesses. We can't say why X causes Y, until we learn something about X.

 

[Unlucky]

I honestly thought it was the Oxycodone and not just me, in fact I even thought Oxycodone had properties that make it an unpredictable drug but obviously my own experiences once again deceived me because of my medical condition.

Its just that some drugs do have the potential to cause the opposite reaction as listed in their side-effects for example in the list of sideffects it says sleeping pills and benzos that normaly relax you or make you sleepy can also cause also cause insomnia or agitation over long term use or in some instances so I just though Oxy was like that too but I guess I was wrong.

Well at least I know better now. Thank you for that great wise and helpful response. Cheers.

 

[Unlucky]

I am still very intrugued by all this though because how can X = both Y or Z or YZ depending purely on what day it is. Because its the same drug I take everyday and the same dose and my medical condition (Dysautonoma) is also the same for the past 11 years so how does the exact same setttings and circumstances cause my vitals to go from NORMAL to either different opposite end of the spectrum such as :

very low<------------------------NORMAL-------------------------->very high

I know no one can answer this but Im just putting it out there cause it is very unusal.

Its kinda crazy that the exact same drugs can make me feel so sedated that it causes my heart to slow down so much (40 bpm) that I start to fear if I fall asleep I may not wake up and then the very next day the same drug causes my vitals to increase so high that I have to take betablockers and lay down to try and reduce it. So hypothetically I could either die from hypotension and my heart slowing to a stop or I could die from hypertension and increased heart rate causing an aneurysm all depending on what random day it is.

Pretty odd when you think about it.

 

[ziddy]

It seems to me that oxycodone is a poor choice of drug for you and you should find something else to use...

 

[theseeker]

My question is how do you know your bp is elevated or lowered? Have you actually measured it? Increased heart rate is NOT an indication of increased pressure. In fact, just the opposite is often true- the heart will race during instances of LOW bp. Racing heart is a common side-effect of many hypertension drugs.

Oddly enough, I can get severe panic attacks from oxycodone. It doesn't happen all the time, but after a while of taking it- I will develop a panic reaction from it. I have no idea why myself.

I wonder if your metabolism of oxycodone doesn't vary. Oxycodone is converted to oxymorphone by the liver. I'm not sure what activity the prodrug has...

 

[RedRum OG]

i find oxycodone has varying effects from stimulant to euphoria to being headfucked/dopey depending on if it comes in a form like percocet-cut with APAP, or oxycodone - (mostly) pure. also ROA depends a lot too - snorting is more dopey feeling, oral is more euphoric and pleasantly sedating

although i have told this to a few other people and they cannot relate at all. diffferent drugs do different things to different people, thats the most important thing you gotta realize when doing drugs

 

[Unlucky]

My question is how do you know your bp is elevated or lowered? Have you actually measured it? Increased heart rate is NOT an indication of increased pressure. In fact, just the opposite is often true- the heart will race during instances of LOW bp. Racing heart is a common side-effect of many hypertension drugs.

Of course I've measured it, I have a blood pressure monitor at home. You are right about something though....as I have mentioned in the past many times whenever I get bradycardia (heart rates of around 40 bpm) its usually accompanied by hypertension (high blood pressure of around 170 - 180) but there have been a few exceptions where its been the opposite or a mixture, its basically roll the dice with Oxycodone. For the record I don't get panic attacks.

 

[Unlucky]

i find oxycodone has varying effects from stimulant to euphoria to being headfucked/dopey depending on if it comes in a form like percocet-cut with APAP, or oxycodone

I take a pure liquid form of oral solution Oxycodone Hydrocholoride, only because I have better control over measuring the exact dose that I can tolerate.

 

[Unlucky]

It seems to me that oxycodone is a poor choice of drug for you and you should find something else to use...

Lol, dont even get me started, people here have heard enough about my quest to find a drug my body can tolerate.

 

[literate]

Oxycodone makes it significantly harder for me to fall asleep, a side effect I was not expecting.

 

[ziddy]

Oxycodone makes it significantly harder for me to fall asleep, a side effect I was not expecting.

This is nothing unusual. Opioids are actually stimulating, especially at lower doses and for people with lower tolerances. It also depends on the specific compound; oxycodone is, in general, far more stimulating than morphine, for example. See this thread for more info:

http://www.bluelight.ru/vb/showthread.php?t=343390