Unusual benzodiazepines?

[danceofdays]

Would any of the following benzo derivatives exhibit recreational properties? I found a site claiming to sell them, and a few look pretty interesting (AKA very similar to commerical benzos on the market).


3-(Acetyloxy)-7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-chlorophenyl)-3-hydroxy-2,3-dihydro-1H-1,4-benzodiazepin-2-one
7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (AKA nor-flurazepam)

 

[Pegasus]

#1 looks like delorazepam with a bit added...

Delorazepam

...Delorazepam is pretty similar to phenazepam (phenazepam has next the halogen, bromine), which is the only reason I noticed this. I have no clue what this could imply, but maybe knowledge of this relationship to delorazepam can help someone with better chemistry/ pharmacology understanding than me...

 

[StaySedated]

7-Chloro-5-(2-fluoro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one (AKA nor-flurazepam)

^this sounds like it has some promise. flurazepam is a very long acting hypnotic benzo. it is also pretty euphoric/relaxing and intoxicating.

this benzo might be a good choice, it would be pretty sedating and last a long time.

 

[seep]

your 2nd image is lorazepam

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.

if chlorazepate isn't active, this probably isn't either. So this purports to be a pro-drug to:

which is lorazepam (your 2nd image)

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this is a metabolite of fludiazepam

 

[indelibleface]

Chlorazepate is active. It`s infrequently prescribed in America (under the brand name Tranxene) and an adjunct to SSRI therapy.

I was prescribed this. I found it relaxing and definitely anxiolytic, but not incredibly hypnotic and not terribly euphoric either. It`s weak stuff, but it works for it`s intended purpose. It tends to be prescribed when a benzo is needed specifically for anxiety while minimizing hypnotic effects.

 

[seep]

Chlorazepate is active

no, it's a prodrug

I meant that if a carboxylic acid substitution there makes it a prodrug, possibly an ester substitution would do similar

difference is esterolysis is enzyme catalyzed, while decarboxyalation requires no enzyme

agree with your assessment of Tranxene btw. It's also good for tapers: I quit Xanax through Tranxene some years ago.