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Are chemists still researching and synthesizing new psychedelics?

the money has moved to the pharmaceuticals; research has been leaning towards finding a "fix-it-all" pill
 
Chemicals are being "invented" all the time. Unfortunately, much of this goes down in shady Chinese labs they care more about a quick profit than a useful chemical. Correct me if i am wrong, but currently there is no body working on the same level as Alexander Shulgin right now. Its sad that he is too old/unhealthy to continue much of his work; If he is having trouble finishing the Shulgin Index to the point where he needs someone to help him write it, i really doubt he is still synthing. I wonder if the man still thinks of new chemicals and writes down possible psychedelics though. Would be awesome if he had a big book of potential psychs yet to be tested written down somewhere.

I actually dream of following in Shulgin's footsteps. Im convinced that i am above the average joe intellectually, and i am planning on studying chemistry and psychopharmacology in college, but assuming become a successful chemist im not sure if there is any way to go about doing what shulgin did legally anymore. And im not risking going to prison and wasting that much effort in school.

Perhaps one day, in a lab located in a country where i can legally make LSD and or research other psychs, but that's unlikely and definitely not worth the risk unless its legal.


Its fun to dream though, lol. If im lucky ill end up researching know drugs in a clinical setting, but even that is incredibly difficult with the drug war. Which sucks because i don't want to end up working for big pharma and there isn't much else you can do with medicinal chemistry.
 
Sasha had a stroke - just in case you weren't aware.

[Tuesday (11/16)] "on the way to the hospital for a scheduled test, Sasha had a stroke. He has been struggling for six months with an ulcer on his left foot that won’t heal, hoping to avoid amputation. Sasha & Ann have been in serious financial trouble for some years, and the coming medical bills will be a burden they can’t bear alone... For non-tax-deductible contributions: Paypal $ to [[email protected]] or snailmail: Sasha Shulgin, c/o Transform Press, PO Box 13675, Berkeley CA 94712. For tax-deductible online donations to support the completion of Shulgin publishing projects that are underway: http://www.erowid.org/donations/project_shulgin.php
 
I honestly think Sasha is gunna recover and be with us for more time. He is so full of vitality, even at his advanced age. What an impressive & truly remarkable man.
 
caseface99 said:
Chemicals are being "invented" all the time. Unfortunately, much of this goes down in shady Chinese labs they care more about a quick profit than a useful chemical. Correct me if i am wrong, but currently there is no body working on the same level as Alexander Shulgin right now. Its sad that he is too old/unhealthy to continue much of his work; If he is having trouble finishing the Shulgin Index to the point where he needs someone to help him write it, i really doubt he is still synthing. I wonder if the man still thinks of new chemicals and writes down possible psychedelics though. Would be awesome if he had a big book of potential psychs yet to be tested written down somewhere.

I actually dream of following in Shulgin's footsteps. Im convinced that i am above the average joe intellectually, and i am planning on studying chemistry and psychopharmacology in college, but assuming become a successful chemist im not sure if there is any way to go about doing what shulgin did legally anymore. And im not risking going to prison and wasting that much effort in school.

Perhaps one day, in a lab located in a country where i can legally make LSD and or research other psychs, but that's unlikely and definitely not worth the risk unless its legal.


Its fun to dream though, lol. If im lucky ill end up researching know drugs in a clinical setting, but even that is incredibly difficult with the drug war. Which sucks because i don't want to end up working for big pharma and there isn't much else you can do with medicinal chemistry.
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Well, there isn't much actual "invention" going on in shady chinese labs. That i'm aware of anyway. They usually just find stuff from research literature or speculation in places like ADD, AFAIK.

David Nichols & his team at purdue do some Shulgin-esque stuff, and Ralph Heim invented the nBOMe class of compounds. Of course all of their work is based on Sasha's :D
 
What I hope is that one day maybe a whole new class of psychedelics will be discovered (in addition to tryptamines, phenethylamines and ergolines). Other then that I imagine only small tweaks will be being made to the existing classics (see the relatively new NBOMe variations) but hey I can always dream
 
I'm curious if anyone's ever gonna make synthetic serotonin.. Would be an awesome drug, I expect!

Not that I know much about chemistry or neurotransmitters, but I expect someone, someday, will figure out a way:)
 
Could it be possible for a chemical to have MDMA's effects without draining serotonin? Like something which produces serotonin instead of using your own?

Also how likely is it that another family of psychedelic chemicals exist besides ones already known (tryptamines, phenethylamines)?
 
Dpt in particular can be just as deep, profound, meaningful as LSD, DMT, MDMA, etc.

But really alot of the RC's can provide worthwhile meaningful experiences.

Its hard to say a drug will surpass the ones you listed, for one you listed drugs with wide range of effects. MDMA and DMT have very little in common, whats useful or beneficial to one person may not be useful or beneficial to another.

Dpt is probably the most unique experience ive had as far as rc's go though.
 
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Make no mistake, there are plenty of scientists doing research on these sorts of things, but they are well bound to work within modern health and safety regs, which shulgin was not so much.

Not to mention the fact that they know that any promising chems they release outside of a professional arena will have their reputations and safety profiles trashed by the legal highs market.
 
Zoinky said:
Of course people will always be making new chemicals... as for surpassing DMT and other psychedelics... I guess never say never.
Click to expand...

You would have said that about surpassing acid or shrooms had you never known about DMT ;)
 
tijn said:
I'm curious if anyone's ever gonna make synthetic serotonin.. Would be an awesome drug, I expect!

Not that I know much about chemistry or neurotransmitters, but I expect someone, someday, will figure out a way:)
Click to expand...

Serotonin has already been synthesized before... Not to mention that increasing the serotonin within the brain is possible through consuming drugs with say for example, serotonin releasers. If you want to see a drug with it's psychoactive effects mainly resulting from it's releasing of serotonin (though it's inhibition of the reuptake of serotonin also increase the extracellular levels of serotonin) look at MDAI. Not that awesome, or really not quite the effects profile that people were looking for. If you want a serotonin releaser which is renowned for it's effects profile, look no further than MDMA (it has more pharmacological properties than just being a serotonin releaser).
 
There IS at least one other core for a psychedelic potential, actually a couple I can think of.

The RH-series, quinazolinediones, developed by tweaking ketanserin until one gets an agonist instead of antagonist, http://en.wikipedia.org/wiki/RH-34

Selective partial agonist of moderate efficacy according to wiki

There are the AL-series indazole based drugs, developed it seems, to treat glaucoma, remaining peripherally restricted. It looks like that bare -OH is making it too polar to cross the BBB here, and it looks also, like those derivatives masking that polarity with an adjacent halide, alkyl or shielding it as an ether (and I bet, fatty acid ester) make for active, CNS penetrant derivatives.

http://en.wikipedia.org/wiki/AL-34662
http://en.wikipedia.org/wiki/AL-37350A Wonder if this makes it in? looks like it might.
http://en.wikipedia.org/wiki/AL-38022A this one does, at least if you are a rat...volunteers anybody?

http://en.wikipedia.org/wiki/PNU-22394 And then theres this...but 5HT2c agonism...yuck, might be another piperazine wannabe. Still, there may be tweaks possible and progress made.
 
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