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Water solubility/ metabolites of JWH-200, 250?

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AliceD420

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I was wondering if the metabolites of JWH 200 and 250 are water soluble. I have found mixed results concerning the metabolites of JWH-018 online and was wondering if anyone knew for sure. If they are water soluble, is it possible to flush them out of your system?

I was also wondering if the metabolites of JWH-200 and 250 are similar enough to JWH 018 and 073 to trigger a false positive on the new metabolite tests for "Spice" and similar synthetic cannibanoids. Any insight is much appreciated as the available info is vague and contradictory.
 
I'm wondering the same thing. JWH-250 is quite different than 018 and 073 in terms of it's molecular structure. As far as metabolites go, it is probably different but I'm not sure I'd bet my freedom on it, which is my current dilemma. Someone is just going to have to give it a try. Also, they all ready have blood tests that can detect JWH-250 metabolites. It's only a matter of time until all currently known JWH's will be tested for.
 
Metabolic oxidation usually results with a more hydrophilic product, and your body does this partially because it allows for the decomposition and excretion of substances responsible for bio-accumulation. For example, the carcinogenic properties of poly-cyclic akanes/alkenes are largely attributed to their reactive oxidant products.

Anyways, the metabolites will be expected to be more polar than the chemicals themselves. Furthermore, JWH-200 being an ethylenediamine (having amino-like acid base chemistry, thus participating in formation of soluble salts), and JWH-250 being an indole, these chemicals could both be expected to be at least somewhat water soluble, 250 more so than 200. A good rule of thumb is the heteroatom : carbon ratio. If the ratio is high, it has a good chance of being polar, think ethanol or glucose. On the other hand, if the ratio is low the chemical will likely be insoluble in water, think diethylether or THC.

Hmmmm... JWH-250 is an ethylenediamine, and it also has bulky polycyclic R-groups with oxygen. The molecule seems somewhat similar to EDTA, as well as other ring structured ligands. Perhaps it could act as a selective chelate? If so, that would have many practical applications to neurochemistry and chemistry in general.
 
Chauncey_GARDENer said:
Hmmmm... JWH-250 is an ethylenediamine, and it also has bulky polycyclic R-groups with oxygen. The molecule seems somewhat similar to EDTA, as well as other ring structured ligands. Perhaps it could act as a selective chelate? If so, that would have many practical applications to neurochemistry and chemistry in general.
Click to expand...

Similar somewhat to EDTA? No way! EDTA is a hexadentate complex ligand with much conformational freedom to literally wrap around larger metal ions. The indole-nitrogen in JWH-250 can't act as complex ligand, as it lacks a lone electron pair. The only other options are the sterically hindered ketone and the methyl-ether. Both are usually crappy ligands... :|

Furthermore does JWH-250 not contain any ethylenediamine-moiety, nor does JWH-200 (just in case you confused them).


Peace! - Murphy
 
i am in the same boat as a few of you guys, and looking for some information on the subject myself. would be very interested in hearing more points of view.
 
AliceD420 said:
I was wondering if the metabolites of JWH 200 and 250 are water soluble. I have found mixed results concerning the metabolites of JWH-018 online and was wondering if anyone knew for sure. If they are water soluble, is it possible to flush them out of your system?

I was also wondering if the metabolites of JWH-200 and 250 are similar enough to JWH 018 and 073 to trigger a false positive on the new metabolite tests for "Spice" and similar synthetic cannibanoids. Any insight is much appreciated as the available info is vague and contradictory.
Click to expand...

The actual metabolism of JWH-073, 200 and 250 was not published anywhere yet. One can only draw comparative conclusions from what is known about the metabolism of JWH-015 (see here) and 018 (see here and here). You also might want to check out what I wrote here, summarizing the health concerns for these compounds.


Peace! - Murphy
 
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