5-Methyl-MDA - potential beta blocker?

[MagickalKat777]

So I noticed something on 5-Me-MDA that I only ever noticed on mescaline - my heart rate and BP both went down. In fact, at one point, I bombed 20mg of 5-Me-MDA with 120mg of methylone and 80mg of mephedrone and still experienced no increase in pulse or BP... just an out of this world roll unlike anything I ever had before haha.

But seriously, is it possible that 5-Methyl-MDA may have some sort of beta blocker action? I'm very prone to stimulation from drugs - and the 5-Me-MDA did EXACTLY like mescaline - I came up on it, I was stimulated and my heart rate was up, then I hit the peak and then the plateau and through both, my pulse and BP were lower than normal.

 

[Rancidltj311]

new poster so be gentle

I caught wind of 5-methyl-mda via wiki about a month back and was immediately intrigued by the description it gave. While the majority of the implications from what I read there didn't hit me till much later I started reading up on potential explanations for the neurotoxic effects of mdma and mda on the brain and what seems to be pointed at is the dual release and inhibiting of serotonin AND dopamine. Dopamine release and reuptake inhibiting characteristic of amphetamines and I would assume it's relatively well known (even via wiki) known that both MDMA and MDA (even moreso than MDMA) substitute for amphetamines in drug discrimination trials. From what i've been reading it seems like the neurotoxicity of both mda and mdma stem from the high release and inhibiting of serotonin and dopamine. Dopamine replenishes faster and then there brain is out of balance and dopamine starts being absorbed by serotonin receptors, etc. I'll admit my understanding is still rather limited, but 5-methyl-mda is a strong SSRA and SSRI, but is a significantly weaker dopamine releasing agent and reuptake inhibitor. Dopamine tends to be associated with the speedier feel and potentially the soreness felt at the end of an mdma roll (even moreso with e pills cut with methamphetamine). What I'm trying to point out though is that it might be the significantly lowered effect on dopamine that took away the speedy feel.

Furthermore, I am extremely curious how the few days after your experience were. Did you get super depressed, were you extremely drained or irritable, any issues with memory? Did post-loading help? I'm getting a bulk order myself and stowing it away for my lady and I so I'm definitely looking for any information i can.

 

[MagickalKat777]

There was no crash whatsoever so far and I was up for 50 hours, with 42 hours being "rolling" between 5 doses of 5-Me-MDA, 3 doses of Meph, and 2 doses of Methylone... even the normal cathinone crash was pretty minimal... my heart was definitely up there... but not like it normally would be...

And it didn't reduce the effects of the mephedrone or the methylone that I could tell so I question its dopamine reuptake inhibition... EDIT: and I do believe I started this experience Sunday morning... like 2:30AM... I know I did because I took my friend home, came home, dosed.

 

[StaySedated]

note that psychedelics can either raise or lower heart rate or blood pressure, although raised is generally more common.

as for 5-methyl-MDA being a beta blocker, i highly doubt it. but it may have some other mechanism and/or metabolite that did what you experienced.

also, my experience with 5-methyl-MDA did not at any point lower my heart rate or blood pressure. it just mildly raised it similar to mescaline, MMDA, or LSD.

 

[StaySedated]

but 5-methyl-mda is a strong SSRA and SSRI, but is a significantly weaker dopamine releasing agent and reuptake inhibitor. Dopamine tends to be associated with the speedier feel and potentially the soreness felt at the end of an mdma roll . What I'm trying to point out though is that it might be the significantly lowered effect on dopamine that took away the speedy feel.

^ he's right, less dopamine release= less stimulation. same concept with MMDA, except MMDA releases and acts as a partial agonist of only serotonin, and it produced very little effects on raised heart rate and blood pressure ime.

 

[Rancidltj311]

here's the question though

Is it possible though, do you think, that because it is fairly serotonin selective as a reuptake inhibitor, and presumably as a releasing agent, that it could be correspondingly less neurotoxic?

 

[StaySedated]

Is it possible though, do you think, that because it is fairly serotonin selective as a reuptake inhibitor, and presumably as a releasing agent, that it could be correspondingly less neurotoxic?

yes. the more selective it is at affecting the neurotransmitter release the less neurotoxic the drug is.

 

[thelearner]

note that psychedelics can either raise or lower heart rate or blood pressure, although raised is generally more common.

as for 5-methyl-MDA being a beta blocker, i highly doubt it. but it may have some other mechanism and/or metabolite that did what you experienced.

also, my experience with 5-methyl-MDA did not at any point lower my heart rate or blood pressure. it just mildly raised it similar to mescaline, MMDA, or LSD.

Didn't know there was anyone else who'd tried this other than MKat...is there a trip report you could point me to of your experience? Would LOVE to read about it. Thanks!