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The Large and Nifty Not-quite-advanced Drug Chemistry, Pharmacology and More Thread

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He's talking about Efavirenz, a first generation antiretroviral drug which has been known to be abused for a while. There are threads already about this topic. I didn't read the article because I don't need to. Efavirenz is a known drug of abuse in Africa, maybe even the drug of choice among some populations.

Whether it acts as an NMDA antagonist, some sort of GABAergic (which it strikes me as- the similarity to benzodiazepines is obvious, even locates the chloro substitution in the same relative position) or something else is unknown.

just for the record, I don't think it's a GABAergic drug, or if it is, that such activity doesn't explain the whole of it.
 
I don't think anyone denies that. On some subjects they are certainly not in my top ten reliable sources, but overall they are quite good.
 
Abuse of efavirenz by smoking has been known for some years, and although the mechanism of action for the CNS effects remains unclear NMDA antagonism seems likely. Probably if it was injected rather than smoked it would produce similar abusable effects while retaining its anti-HIV efficacy and being slightly less toxic than smoking pill binders...though injecting crushed pills is hardly much better!

seusemgoose said:
I know this doesn't make sense to smoke, but I watched a presentation on this and I'm pretty sure the main drug that is used in this manner is warfarin
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Actually there are cases reported of bromdifacoum (a more potent analogue of warfarin) being abused in combination with marijuana or heroin, apparently it acts as a potentiator somehow...

http://www.ncbi.nlm.nih.gov/pubmed/9111096

http://www.ncbi.nlm.nih.gov/pubmed/17022046
 
The bruxism I experience is always mild, but 1000 mg magnesium consistently doesn't nothing for it (I take magnesium as a supplement pretty often anyway).

ebola
 
There's no way that Africans are smoking warfarin or superwarfarin several times a day. At least I seriously hope not. They'd be hemorrhaging on every corner.
 
I never noticed any sort of potentiation of drugs while using warfarin.

People will take anything to try and get high...
 
with phenethylamine psychedelics, there is typically a strong positive correlation between potency and duration. any ideas why?
 
thenightwatch said:
with phenethylamine psychedelics, there is typically a strong positive correlation between potency and duration. any ideas why?
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I would say if the substitution is such that it does not fit well enough in MAO to be broken down, there is much more of it to have effect so less material is needed. At the same time it is broken down slower from pharmacokinetics so duration is longer....
 
after all these are people who kill albinos because witch doctors tell them to
 
what is up with the para halogenated cathinones?

I bet they are even more euphoric than their amphetamine counterparts, but also neurotoxic/deadly
 
First of all it depends on which halogen, lately there have been threads on ADD about the para halogenated stimulants and the message I am still getting (also meaning I echoed what I have read in the course of a longer time without it being rejected) is that the fluoro substituted ones are the only halogen-type with acceptable neurotoxicity though how much of this is assumed or based on subjective effects (from what I understand you don't have to feel the neurotoxicity) or experiential data from lab research is unclear.

My personal opinion is that 4-FMC, 4-FA an 2-FA were all among the smoothest feeling stimulants I have tried. Euphoric but more muffled than in your face, rather sensitive and subtle, which I like. Kind of like as if there were a soft blanket over it, bk-MDMA produces this as well in me more than MDMA.
 
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from what I understand, all of the para halogenated amphetamines are neurotoxic
 
would people assume Flephedrone has more side effects than mephedrone?
 
Solipsis said:
I would say if the substitution is such that it does not fit well enough in MAO to be broken down, there is much more of it to have effect so less material is needed. At the same time it is broken down slower from pharmacokinetics so duration is longer....
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i think your logic is sound, and that is almost certainly a part of it. however, i feel like there's got to be more to the story than that!
 
bupe in water

will it decompose in water? i've made a nasal spray, just wondering if it's stable or not.
 
i was wondering the same. I want to delute the 8mg Bup tablets into a moonshine (alcohol 55%).
I know is highly solvent in alcohol,but please some one tell how much alcohol ex. per 5 pills.
 
Pretty sure it doesn't in any appreciable amount. It's not like heroin in that way. I'm pretty sure some BLers pretty much do the same thing as you with their bupe to titrate their doses.
 
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