oxycotin effect on a disease ITP (Idiopathic thrombocytopenic purpura)

[lman_15]

I have a gf who has some bad health, she had low blood platelet levels nd needs to get blood transfusions occasionally once every 3-4 weeks.. she has a disease called ITP (Idiopathic thrombocytopenic purpura) which causes this..

she uses 40-80mg of oxy a weekend and that's it, she never uses more or during the week.. and has only been using for a month or so.. does using oxy thin the blood? would it make her more sick by using? i know it won't make her better but will there be serious repercussions from her using oxy, and will it increase the negative affects of her disease?

i've been trying to get info for a long time so any information would be greatly appreciated

 

[raybeez]

I have a gf who has some bad health, she had low blood platelet levels nd needs to get blood transfusions occasionally once every 3-4 weeks.. she has a disease called ITP (Idiopathic thrombocytopenic purpura) which causes this..

she uses 40-80mg of oxy a weekend and that's it, she never uses more or during the week.. and has only been using for a month or so.. does using oxy thin the blood? would it make her more sick by using? i know it won't make her better but will there be serious repercussions from her using oxy, and will it increase the negative affects of her disease?

i've been trying to get info for a long time so any information would be greatly appreciated

She must avoid any drugs that increase or release levels of serotonin in the blood as platelets have high levels of 5HT receptors.

Also avoid cocaine at all costs. Cocaine is notorious for causing platelet activation and if this happens in the setting of ITP she could develop spontaneous internal bleeding.

The only problem I can see with opiates is histamine release, as histamine can synergize with monoamines in causing platelet aggregation. Be careful to stay below oxycodone doses that would make her red and itchy (sign of histamine release).

Is her ITP autoimmune? (is she being treated with prednisone?)

 

[lman_15]

Is her ITP autoimmune? (is she being treated with prednisone?)

her ITP is autoimmune and she was being treated with prednisone she stopped taking it and might be put back on it

 

[DavidStayzFadedd]

I have a gf who has some bad health, she had low blood platelet levels nd needs to get blood transfusions occasionally once every 3-4 weeks.. she has a disease called ITP (Idiopathic thrombocytopenic purpura) which causes this..

she uses 40-80mg of oxy a weekend and that's it, she never uses more or during the week.. and has only been using for a month or so.. does using oxy thin the blood? would it make her more sick by using? i know it won't make her better but will there be serious repercussions from her using oxy, and will it increase the negative affects of her disease?

i've been trying to get info for a long time so any information would be greatly appreciated

it might but idk. if she's only using on weekends then why not quit? or wait a bit 4 her tolerance to go down a little. not saying its bad to do, idk with her condition n all.

 

[lman_15]

if she's only using on weekends then why not quit? or wait a bit 4 her tolerance to go down a little.

well she likes using occasionally obviously she can quit but why if its not having a negative health effect.. thats what i am trying to figure out?

raybeez you seem to know a lot and i really appreciate your feedback this is a girl i truly care about.. if you wouldn't mind could you give me some more feedback its really appreciated

Is her ITP autoimmune? (is she being treated with prednisone?)

her ITP is autoimmune and she was being treated with prednisone she stopped taking it and might be put back on it

 

[raybeez]

raybeez you seem to know a lot and i really appreciate your feedback this is a girl i truly care about.. if you wouldn't mind could you give me some more feedback its really appreciated

Is her ITP autoimmune? (is she being treated with prednisone?)

her ITP is autoimmune and she was being treated with prednisone she stopped taking it and might be put back on it

Like I said above, try to keep the oxycodone (or other opiate) dose below the level that induces significant histamine release. If she's getting really itchy, don't take more. My concern here is that the histamine might excite some immune cells, triggering platelet destruction.

Strangely, anti-histamines are one of the more common drug triggers of ITP. If she does get itchy, don't take any anti-histamine to counteract it. This could also trigger platelet destruction. This includes anti-histamines that might be taken to enhance the high, for example:
Gravol, benadryl, tagamet (Dimenhydrinate, diphenhydramine, cimetidine). Even Zantac/Ranitidine should be avoided.

Don't take oxycodone 48-72 hours before getting plasma, platelets, or any other blood products their giving her. Any residual histamine can cause her to have an allergic reaction to the transfusion.

And I probably don't need to tell you this but any sudden new onset bruising, nose bleeds, etc ---> ER immediately.

be safe.

 

[lman_15]

thank you very, very much for your advice.. you are one of the few people who actually know about this i am very impressed.. 1 more question, she was thinking of doing mdma would that not be such a good idea?

 

[raybeez]

thank you very, very much for your advice.. you are one of the few people who actually know about this i am very impressed.. 1 more question, she was thinking of doing mdma would that not be such a good idea?

I think it would be a bad idea, but I can't say 100% for sure.

Platelets have serotonin receptors and store serotonin inside. SSRIs are one class of drugs which can induce ITP, so I would say avoid anything that has the possibility of altering blood serotonin levels.

Cocaine is by far the worst drug for killing platelets, but I'm not sure if this is something unique to cocaine, or if this is true for any dopamine reuptake inhibitor. Just to be on the safe side I'd avoid any stimulants and anything that releases serotonin.

 

[lman_15]

alright, once again thank you very much for the informative response.. i have passed along the information to my gf she is very grateful to hear from an informed person on the subject and so am i.. take care