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Idea... keeping tolerance low by switching between MDA and MDMA?

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rolling_anon

Bluelighter
Joined
Oct 27, 2010
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Would this work? I hear that there is no proven cross-tolerance between the two compounds. So, if one hypothetically didn't want to build a tolerance to MDMA would one be smart to change up roll weekends with MDA or MDMA? And I searched, all I could find in a search was the difference between the two compounds.

The only times one has rolled has been the past 5 weekends, 1 pill each weekend. Staying healthy, pre/post loading with C/ALA, taking 100mg 5htp before sleep, good diet... One might be afraid of "losing magic", although It seems there is debate as to if it is psychological or not. Still wanting to play it safe and not build a tolerance.
 
i'm unsure about your question, but all i'm sayin' is 2-3 months is essential between rolls to let your brain recover. When you're in the midst of MDMA abuse you don't really realize how much it can harm your health. Try doing some psychedelics or just smoking weed
 
Basically I'm asking... If I wanted to keep MDMA tolerance between frequent (>1 week) rolls... would it be helpful to take MDA one weekend, MDMA the other weekend, instead of MDMA both weekends.
 
rolling_anon said:
Basically I'm asking... If I wanted to keep MDMA tolerance between frequent (>1 week) rolls... would it be helpful to take MDA one weekend, MDMA the other weekend, instead of MDMA both weekends.
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I understand the phrasing, I'm just telling you in the harm reduction spirit of bluelight that it's extremely unhealthy to roll every other weekend, or even every month
 
I am pretty sure there is a strong cross tolerance between the two.

(after all, they affect many common sets of receptors)
 
Well.. I've got a few more shows to attend. lol

and,

I've done plenty of research on pre/post loading, nor do I have any issues with hangovers or memory. If I do build a tolerance (i.e. having to take more than 2 pills to roll) I'll stop. I know where to draw the line. :]

I'm just curious if switching between MDA / MDMA is a good idea, that's all.

http://www.mdma.net/mdma/cross-tolerance.html

Cross-tolerance to MDA did not develop in any of the 4 groups of rats.
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^ I know the study is on rats, but I'm looking for some personal experience to chime in.
 
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There may not be any cross tolerance between the two (this is highly likely), however, their receptor affinity profiles are quite similar and you will definitely notice the serotonergic euphoria of MDA and MDMA greatly diminished if you do this.

I used to roll every weekend and never noticed much of a tolerance... but I also ate like half a bottle of 5-HTP a night to recover...

I recommend at LEAST 3 weeks inbetween rolls to give your body time to recover.
 
In the spirit of harm reduction, there are factors to consider other than cross tolerance, such as malnutrition, dehydration, lowered immune system, etc....basically all the things youd have to worry about anyways. You may end up taking less overall, but the risks are similar. Id say dont do it.
 
MagickalKat777 said:
you will definitely notice the serotonergic euphoria of MDA and MDMA greatly diminished if you do this.
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Are you implying that if MDA and MDMA are interchanged it will raise the tolerance for both even though it is likely that there is no cross-tolerance?
 
rolling_anon said:
Are you implying that if MDA and MDMA are interchanged it will raise the tolerance for both even though it is likely that there is no cross-tolerance?
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They both release serotonin, dopamine, and norephinephrine. And mice are completely different from humans.

If the monoamines required for the effects are in low levels, the effects will be diminished, tolerance or not.
 
Okay, well thanks for your input. We'll see what happens. Unfortunately all we have is mice testing and anecdotal evidence. What can we do with that? Even so, not all people even report of "losing magic" and it may be all psychological... Nobody really knows! Lol

I guess all we can do is study, know how to counter-effect what we put into our bodies, stay healthy (diet,exercise), take anti-oxidants and pro-serotonin supplements, and hope for the best. :)

Good night everyone.
 
I remember reading something about this in PiKHAL. How would you know you have MDMA or MDA?
 
In my personal, first hand experience, there is definitely a cross tolerance. You'll certainly do some damage if you choose to try this, but you seem quite dead set on it. Let us know how it all turns out for you =) We can use this as future, undeniable, qualitative evidence for future reference :D
 
AylaV said:
In my personal, first hand experience, there is definitely a cross tolerance. You'll certainly do some damage if you choose to try this, but you seem quite dead set on it. Let us know how it all turns out for you =) We can use this as future, undeniable, qualitative evidence for future reference :D
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In other words, we can use this for future harm reduction since you are very likely going to destroy yourself - particularly with MDA. While I enjoy MDA, it is extremely neurotoxic.
 
AylaV said:
In my personal, first hand experience, there is definitely a cross tolerance. You'll certainly do some damage if you choose to try this, but you seem quite dead set on it. Let us know how it all turns out for you =) We can use this as future, undeniable, qualitative evidence for future reference :D
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Although I appreciate the input, you have any sources to back up your claim? I'm not saying you're wrong, but I'd like to see some data supporting your statement. I'm just here to learn, because there is no exp with MDA here. :) If your sources back up your claims I won't be catching anymore MDA on my hunts...
 
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rolling_anon said:
Although I appreciate the input, you have any sources to back up your claim? I'm not saying you're wrong, but I'd like to see some data supporting your statement. I'm just here to learn, because there is no exp with MDA here. :) If your sources back up your claims I won't be catching anymore MDA on my hunts...
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Both MDMA and MDA activate on pretty much the same mechanism. They both release serotonin. They have cross tolerance because they are so chemically similar. Both release an amount of serotonin that would never normally be released, since these are the only drugs(MDxx compounds) that specifically release serotonin as their primary mechanism, they have a cross tolerance. If MDA and MDMA weren't so closely related, I'd believe it would be a different story.
 
Again I appreciate your info, but again you have no source to back up your claim.

I opened the thread with a source... http://www.mdma.net/mdma/cross-tolerance.html , that seems to be quite credible.

Not tryin' to be rude here, but if you claim this or that I'd really like to see some sort of data along with your claim.

Good day ya'll :)
 
You're just not getting it.

There is a HUGE difference between the brains of lab animals and humans. If you don't have the SEROTONIN, you will have a TOLERANCE to the effects of the drugs!
 
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