Ethnicity is a factor in the occurrence of CYP2D6 variability. The prevalence of CYP2D6 poor metabolizers is approximately 6-10% amongst white populations, but is lower in most other ethnic groups such as Asians ( 2% ). In blacks, the frequency of poor metabolizers is greater than for whites. The occurrence of CYP2D6 ultrarapid metabolisers appears to be greater amongst Middle Eastern and North African populations.
This variability is accounted for by the differences in the prevalence of various CYP2D6 alleles amongst the populations - approximately 10% of whites appear to have the non-functional CYP2D6*4 allele, while approximately 50% of Asians possess the CYP2D6*10 allele which should produce decreased CYP2D6 function; however this still appears to be within the normal range and are still grouped as intermediate metabolisers.
lacking effect for injected opiates rules out enzymes for me. Sounds like an anti-psychotic to me.
Could be the enzyme thing, though. Could be the opiate and MDMA issues are completely different.
And maybe not smoking weed before but after your peak is a little gone may help also.
Your single pill experiences... Pokeballs right? One pill might not have been enough for you. But 3 transformers? Almost sounds like pipes since you had pupil dilation and couldn't sleep, just missing all the good parts of MDMA.
I doubt you'd buy a test kit because of your situation, so try to find someone that has one. I mean it'd be a huge coincidence, but maybe your high doses were bunks, and one pill of good stuff doesn't cut it for you (doesn't for me).