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Effects/behavioral changes of animals by drugs

billy_m100

Bluelighter
Joined
Oct 2, 2010
Messages
163
I have been rather interested in how certain drugs affect animals, i have no intent on harming any creature by use of drugs. I'm only asking for the sake of research and knowledge.

How do certain animals react on cannabis, LSD, shrooms, MDMA, etc.

My intent on this reasearch is to see if animals are more "like us" than we realize. If they can react close enough like we do that may mean they feel more emotion than we had thought before.

If you have knowledge on the reactions/behavorial changes of animals while under the influence of drugs post a reply.
 
Id rather have bluelighters discussing me with this not some search engine haha
 
Perhaps you may want to be more specific in what you would like to know. Most drugs have been tested on animals (the ones worth taking) and there is extensive documentation on their affects in journals.

Animals are very much like humans in many ways. From an evolutionary point of view it is very easy to see which mammals are closely related to humans. This doesn't require comparison of substance reactions. Maybe you are interested in the 'minds' of humans and other mammals. Perception differences amongst mammalians would be a good topic to research. Or try higher levels of cognitive ability.

I do urge you to research this extensively yourself if you really are interested. There is huge disparity in the data available. Surely this would be too much for any single post to reveal what you are looking for.
 
Obviously only a few animals can communicate with humans using sign language so lots of creative biologists have invented methods which produce quantifiable results with regard to characterizing the effects of an intoxicant. Unfortunately, subtlety really accounts for a lot and much of this subtlety is lost when experimenting with a rat or similar laboratory animals. For example, I really don't like the way crack makes me feel, but if one were to observe my behavior the last time I tried it 20 years ago, as I was searching the carpet for crumbs, one would have gotten the impression that I thoroughly enjoyed the experience.
 
Runera could you explain that more if give a link?

Sorry, what do you mean? Give you a link?

If you have access to journals start there. I'm not aware of any paper which covers such a broad subject! There are thousands for you to read!
 
When I read the title two books came to mind I've come across Amazon a few time, Intoxication: The Universal Drive for Mind-Altering Substances by Ronald K. Siegel Ph.D and Animals and Psychedelics: The Natural World and the Instinct to Alter Consciousness by Giorgio Samorini. I've read neither so I can't say how much it'd help with what you are looking for, but it's a start.

Intoxication can be find on google books here.
 
When 2 identical sets of rat pups were weaned at 2 weeks vs. 4 weeks. Later on the ones who were ripped away from their mothers nips and general contact/attention of a mother earlier were significantly more inclined to becomes addicted to opiates.

Implying that being with a mother for as long as possible makes for more emotionally adjusted and less addiction prone people/animals.

Also when rats were caged in isolation in small cages with very little contact they were the rats who would, given the chance, self administer cocaine to the point of not eating or sleeping and eventually die of malnutriction or a heart attack or stroke. However rats given tones of room to romp and play, an equal amount of male females to interact with would try out the cocaine but very rarely succumb to life threating addiction.

The implication being that the "tests" that said cocaine is so bad for you look how it turned these rats/mice into total coke feinds that went hard till they died, were completly flawed because given a positive life and lots of emotional interaction with other rats and if they were happy and not locked in a tinny cage the rate of addiction was minimal.




the bottom one was called rat park study, its pretty old and well known, the 2nd one I read in a book by Gabor Mate, in the realm of hungry ghosts, really good book
 
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First, you need to figure out what aspect of behavior you're interested in. Then, you need to figure out which procedures are used by psychologists to measure those behaviors. When you know that, you should do searches for (drug name) and (name of behavioral paradigm).

Is the drug rewarding? You might want to know about conditioned place preference and intracranial self stimulation thresholds.

Is the drug stimulating? You might want to know about locomotor activity in an open field, which can also tell you something about anxiety.

If you want to know about anxiety in particular, maybe look for elevated plus maze papers.

If you're interested in various aspects of addiction, you might look for locomotor sensitization papers, self-administration and reinstatement, progressive ratio schedules, etc.

What about cognition? Some standard tasks are radial arm mazes, T-maze delayed alternation, delayed nonmatching to sample, novel object recognition, the 5-choice serial reaction time task, reversal learning, attentional set shifting, etc.

pubmed.com is the place to look for this kind of information. Each drug has a certain mechanism of action. Often, but not always, this involves mimicking or blocking a natural chemical at a receptor. A drug that mimics a natural chemical at a receptor is an agonist. A drug that blocks the natural chemical is an antagonist. If you are interested in THC, it's helpful to know that THC is an agonist at the "CB1 receptor." Researchers often use laboratory drugs that do the same thing as "drugs of abuse," but are easier to work with because they're not scheduled. For example, WIN 55,212-2 is often used in place of THC.

You can also get some insight by reading about what drugs with opposite mechanisms as drugs of abuse do. For example, SR141716A ("rimonabant") is an antagonist at the CB1 receptor. It reduces appetite, which is like the "anti-munchies."

At first, it may seem like the animal behavior paradigms are too simple to be really interesting, but I think we give humans too much credit. If you put infrared beams at regular intervals in someone's apartment, they'd move around more and break more of the beams after taking a stimulant, just like a rat or mouse.
 
I have given my cat about 15mg of crystal meth before.

Within a short amount of time the cat's pupils were extremely dilated. The cat then proceeded to hide in the bathroom in the corner (a relatively dark place) and then began meowing in distress.

Upon examination, I could tell that the cat could not focus on objects properly, could not even see my face or a snack in my hand. His head was moving around constantly as if he was "looking" but could not see.

I think because cat's vision is so different to humans, the extreme dilation of his pupils really screwed up his vision to the point he could not see clearly at all. This would be very frightening to an animal, and probably the reason he went and hid in the bathroom with his back to the corner.

Additionally, the cat did not sleep, had a high heart rate, and the effect lasted for 16hours I would guess.

At one stage I administered 5mg of Valium to the cat to help calm him down (after reading about it on the internet). This actually worked very well and he was calm and quiet for a while but the after the effect of the Valium wore off, things were back to the frantic meowing.

I do not think the cat enjoyed the experience, mostly due to not being able to see properly - I think if the same happened to me, I would not enjoy it either.

So in a way, cats and humans are similar after all.
 
I have given my cat about 15mg of crystal meth before.

Within a short amount of time the cat's pupils were extremely dilated. The cat then proceeded to hide in the bathroom in the corner (a relatively dark place) and then began meowing in distress.

Upon examination, I could tell that the cat could not focus on objects properly, could not even see my face or a snack in my hand. His head was moving around constantly as if he was "looking" but could not see.

I think because cat's vision is so different to humans, the extreme dilation of his pupils really screwed up his vision to the point he could not see clearly at all. This would be very frightening to an animal, and probably the reason he went and hid in the bathroom with his back to the corner.

Additionally, the cat did not sleep, had a high heart rate, and the effect lasted for 16hours I would guess.

At one stage I administered 5mg of Valium to the cat to help calm him down (after reading about it on the internet). This actually worked very well and he was calm and quiet for a while but the after the effect of the Valium wore off, things were back to the frantic meowing.

I do not think the cat enjoyed the experience, mostly due to not being able to see properly - I think if the same happened to me, I would not enjoy it either.

So in a way, cats and humans are similar after all.

I hope you are joking dude...
 
I have given my cat about 15mg of crystal meth before.

Within a short amount of time the cat's pupils were extremely dilated. The cat then proceeded to hide in the bathroom in the corner (a relatively dark place) and then began meowing in distress.

Upon examination, I could tell that the cat could not focus on objects properly, could not even see my face or a snack in my hand. His head was moving around constantly as if he was "looking" but could not see.

I think because cat's vision is so different to humans, the extreme dilation of his pupils really screwed up his vision to the point he could not see clearly at all. This would be very frightening to an animal, and probably the reason he went and hid in the bathroom with his back to the corner.

Additionally, the cat did not sleep, had a high heart rate, and the effect lasted for 16hours I would guess.

At one stage I administered 5mg of Valium to the cat to help calm him down (after reading about it on the internet). This actually worked very well and he was calm and quiet for a while but the after the effect of the Valium wore off, things were back to the frantic meowing.

I do not think the cat enjoyed the experience, mostly due to not being able to see properly - I think if the same happened to me, I would not enjoy it either.

So in a way, cats and humans are similar after all.

This is what I mean. How similar are animals and humans in terms of drug physical/mental/emotions while under the influence of a drug. And how similar the brain damage and possible healing of the two.

I wouldn't know what that would be called.
 
15 mg are already a good dose for an adult human (with tolerance). Considering the far lower weight of a cat, I would guess that the poor animal had one hell of a trip...

Why man, why??


- Murphy
 
I doubt many people would find the humor in such a joke and if you aren't joking and you really do have trouble caring for an animal without torturing it, then you should reconsider pet ownership. I don't even like cats, and I consider myself able to laugh at many things others find sophomoric or sick, but christ I'm speechless that you'd think anyone would be interested or amused by such a statement.

If there was something that could be learned from this I'd be a little more accepting, but I highly doubt anything could possibly be learned from such an experiment without even a control group and outside of a laboratory setting except for the fact that your cat can take a high dose of meth and that you have sociopathic tendencies and trouble empathizing even with your own house pets.
 
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I don't think any animal should have a dose of anything that is meant for a human. And yet labs do it. Why can't they give them an amount a cat could handle?
 
I don't think any animal should have a dose of anything that is meant for a human. And yet labs do it.

If this were the case. There would be a lot of dead human test subjects in order to get a large number medicines we have on our chemist's shelves.
 
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