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Piracetam or Memantine?

Tomer

Tomer

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Hey all-

This is somewhat of a broad question so I apologize in advance. I take amphetamines on a semi-regular basis and was looking into certain types of drugs that could combat and lower the tolerance of my use.

I was originally looking at ordering Memantine but forgot about the rave reviews that Piracetam has always received. I know that both drugs are used to combat Dementia and help with cognitive use. Which would you say is more helpful in targeting NDMA agonist (lowering tolerance of amphetamine) while improving cognition in the brain? Is it possible of taking both drugs on a routine basis? Any anecdotal or expert advise is welcome. Thanks for the help.

Cheers

Tomer
 
memantine being a moderate NMDA antagonist would probably be best fit on getting more bang for your buck with amphetamine as i believe too have read that it lowers tolerance too such things. On another note as does magnesium for that matter. Piracetam would also probly help if you can get both.
 
Hi there - yes it is a bit of a broad question, but it helps to gather a variety answers too.

I find the best supplement for reducing tolerance levels is the amino-acid L-tyrosine.

As you may know, L-tyrosine is the precursor to dopamine, and will help replenish your dopamine storage which tends to get depleted whenever you get high.

Additionally, you can pre-load L-tyrosine before your amphetamine dosages, to create and excess of dopamine in your body, thus increasing the effect of your high.

I've been using this supplement for years and years now with lots of success. I like 500mg or 1000mg per dosage once per day on the day before, during, and after an amphetamine session.

The only problem I can see with this...is that it sometimes works "too good" and leaves you with no reason to ever stop your amphetamine habits (because L-tyrosine acts as a cure for most of the side effects due to dopamine depletion, comedown effects)
 
I'm actually doing an experiment at the moment, some think piracetam will interfere with the anti tolerance prevention of memantine as it modulates NMDA in a positive way, will let you know.
 
Piracetam doesn't lower tolerance AFAIK, but rather enhances the cognitive boost of amphetamine. Also as Medieval points out, the Racetam drugs seem to reverse the effects (good and bad) of NMDA antagonists, so I wouldn't be surprised if they actually accelerate tolerance accrual.

As for Memantine, it has indeed shown to be helpful, but I sure hope you have it covered by insurance! If your point is to be more economical, then using memantine to reduce amp tolerance is like using a rod of pure gold to clean out a sewer. A more economical solution would be its analogue, amanitidine, but IME the latter seems to have mild stimulant effects of its own so it may or may not mix well with other stims...
 
Piracetam in combination with choline is great for enhancing the effects of chemicals and I have noticed it helps to balance the brain out. I have noticed that it helps to balance the brain out and won't allow it to enter extreme emotional states...up or down. It is also useful in preventing the some negative effects of alcohol intoxication.

http://www.ncbi.nlm.nih.gov/pubmed/16995433
 
Thanks for some of the responses. Jams, long time...hope you're doing well.

I have actually found memantine to be quite cheap (Sold under the Indian Generic), but am unsure of its quality. Anyway, I have ordered Piracetam, and will probably order the Choline, as well. Can anyone explain why they have to be taken in conjunction with one another (Piracetam and Choline)?

Cheers

Tomer
 
"Choline supplements are often taken as a form of 'smart drug' or nootropic, due to the role that the neurotransmitter acetylcholine plays in various cognition systems within the brain. Choline is a chemical precursor or "building block" needed to produce the neurotransmitter acetylcholine, and research suggests that memory, intelligence and mood are mediated at least in part by acetylcholine metabolism in the brain."

"Choline is used in the treatment of liver disorders,[31][32] Alzheimer's disease,[33] and bipolar disorder.[34]

Some studies show that as a supplement, choline is also used in treating hepatitis, glaucoma,[35] atherosclerosis, and, possibly, neurological disorders.[2]

Choline has also been proved to have a positive effect on those suffering from alcoholism.[36][37]"

Piracetam can also help to increase the uptake of choline.
 
Nickelodeon said:
Hi there - yes it is a bit of a broad question, but it helps to gather a variety answers too.

I find the best supplement for reducing tolerance levels is the amino-acid L-tyrosine.

As you may know, L-tyrosine is the precursor to dopamine, and will help replenish your dopamine storage which tends to get depleted whenever you get high.

Additionally, you can pre-load L-tyrosine before your amphetamine dosages, to create and excess of dopamine in your body, thus increasing the effect of your high.

I've been using this supplement for years and years now with lots of success. I like 500mg or 1000mg per dosage once per day on the day before, during, and after an amphetamine session.

The only problem I can see with this...is that it sometimes works "too good" and leaves you with no reason to ever stop your amphetamine habits (because L-tyrosine acts as a cure for most of the side effects due to dopamine depletion, comedown effects)
Click to expand...

Wouldn't it make more sense to use L-Dopa? As I see it is used in treatment for Parkinsons? From what I am reading, it is used in increasing Dopamine levels.

Tomer
 
Memantine seems like it would be useful for a lot of things..... I bet it works wonders when taken when withdrawing from benzos...
 
Keep in mind everybody that Memantine is MUCHO MUCHO EXPENSIVE. Gettin it prescribed (to save on taxes through your medical insurance) for someone who doesn't have Alzhaimer or similar neurocognitive diseases is hard. Even if ordered in bulk I doubt it's gonna be that cheap due to cost of production.

A much much cheaper though less potent by weight 'analogue' of memantine is Amantadine which even though it shares similar NMDA, anticholinergic and monoamine releasing action it is rather used as an antiparkinsonian and antiviral drug with some off label used for treatment of ADHD.
 
/navarone/ said:
A much much cheaper though less potent by weight 'analogue' of memantine is Amantadine which even though it shares similar NMDA, anticholinergic and monoamine releasing action it is rather used as an antiparkinsonian and antiviral drug with some off label used for treatment of ADHD.
Click to expand...

For treatment of ADHD? How incredibly odd.

I may just have to try it, actually.
 
Actually... its only 8.50 for 10 10mg pills...

How much of a dose would be recommended for NMDA antagonism? I'm curious about the usefulness of this one in benzo w/d.
 
Memantine is dirt cheap if you know where to get it from, cant say more on this forum, but price really isnt an issue with it.
 
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