Stainless steel Teflon-insulated electrodes 0.003 in. diameter, each with three to six leads separated by 2 ram, were implanted into the following brain regions: right mid septal, right hippocampus, left and right amygdalae, right anterior hypothalamus, right posterior ventral lateral thalamus, left caudate nucleus, and at two subcortical sites within the left lobe of the cerebellum. Cortical leads were placed under the dura at sites in the left and right frontal regions, left and right parietal areas, and right temporal region. Triple-lead silver ball polyvinyl chloride acetate-insulated electrodes were im- planted into the left anterior and left posterior septal region. The silver ball contact points were 0.5 mm in diameter, each 2 mm apart. Intracerebral cannulae were implanted into the septal region bilaterally and into the hippo- campus...
... only stimulation of the septal region resulted in a pleasurable experience, with stimulation of other sites being either neutral or aversive...
...A program involving both passive (other- induced) and self-stimulation of the septal region was begun the following day. A summary of the stimulation sessions is presented in Table 1. During and following the initial three periods of passive stimulation B-19 exhibited an improved mood, smiled frequently, stated that he could think fnore clearly, and reported a sense of generalized muscle relaxation. He likened these responses to the pleasurable states he had sought and experienced through the use of amphetamines. Moreover, he reported an associated state of sexual motivation.
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