Long-term serotonergic changes from LSD?

[thelearner]

Have recently begun experimenting with LSD, and it's an absolutely delightful substance. However, I'm concerned that since it's postulated (or is?) a 5-HT2A agonist it could potentially cause long-term serotonergic changes.

Does anyone know of any studies on LSD and its potential to cause changes in the serotonin system or other parts of the brain? I haven't found anything to indicate this is a concern, but initially thought this was not a major issue with MDMA and later discovered it's quite neurotoxic.

I want to have fun, but me and my brain, we're tight. I take care of him, and he takes care of me. Need to make sure he's safe.

 

[atara]

It's receptor affinities/efficacies are well-studied, and it has not been shown to cause any sort of brain damage.

 

[thelearner]

I would LOVE to read any studies you could point me to. My roomie has access to PubMed, etc. so a link to an abstract would be just fine, too.

What about receptor downregulation with heavy and/or regular use?

 

[thelearner]

Also, any data about concomitant usage with MDMA?

 

[<pyridinyl_30>]

LSD can, in certain individuals, have a moderate to drastic impairment of psychosocial coping skills. You know, like, woah man.

 

[atara]

http://www.maps.org/research/cluster/psilo-lsd/cns-neuroscience+therapeutics_2008-passie.pdf

Downregulation is quickly reversible, axon degeneration less so, and neuronal death is permanent.

 

[Deleted member 137730]

Also, any data about concomitant usage with MDMA?

I've only seen one article on this and it was nothing conclusive. Anecdotally though, what ive seen it not pretty as far as long term affects.

 

[Symposion]

Also, any data about concomitant usage with MDMA?

I'm really afraid you are wrong in the place you are posting and the topics you are choosing.
No idea of what the h*** are you looking for here.

The same I told you in the other thread you've started about MDMA and trying to make the allegedly neurotoxicity be the responsible of the Loss of Magic??

Don't really know what are you looking for.

 

[atara]

Also, any data about concomitant usage with MDMA?

Candyflipping is generally believed to be no worse than ordinary rolling, as LSD does not affect SERT and DAT to any significant level.

 

[thelearner]

http://www.maps.org/research/cluster/psilo-lsd/cns-neuroscience+therapeutics_2008-passie.pdf

Downregulation is quickly reversible, axon degeneration less so, and neuronal death is permanent.

That's what I was looking for! Thanks!

Looks like I needs to spend some more time on the MAPS site.