JWH Solubility:
I am interested in using liquid dosing for JWH compounds (for oral use) - With doses in the sub-10mg range, my milligram scale doesn't cut it. The JWH's however, have been frowned upon by the Gods of Solubility, it seems.
A nice target for solubility would be 10mg/ml (for dosing with droppers or some lovely 1.5ml graduated plastic snap-top vials i have).
Water:
Insoluble, or so close to insoluble that it might as well be.
Ethanol:
JWH-018 - Probably lower than JWH-073 (not tested, but expected from structure)
JWH-073 - <5mg/2.5ml
JWH-250 - >10mg/ml (10mg/ml dissolved within 15 minutes under gentle heat, and didn't precipitate out when returned to room temperature)
Vegetable Oil:
JWH-073 - Insoluble
Heptane (no, i wasn't planning on drinking it):
JWH-073 - Poor (based on crude test)
JWH-250 - Poor. Somewhere around the 3-5mg/ml range.
Anyone know of a solvent that's okay to drink that will dissolve JWH-018 or 073 reasonably well, or have suggestions that i should try?
Or any solvents, toxic or not, that dissolve JWH-018/073 reasonably well?
Cleaning JWH-018/073:
Commercial JWH compounds with the napthoyl moiety often come contaminated with an unidentified yellowish contaminant.
I am not sure what this contaminant is, but based on the odor, and knowing that adding the napthoyl moiety is the last step in the preparation of JWH-### compounds, it stands to reason that it is some naphthalene derivative - it can't be a good thing to get into our body.
I asked about this in an earlier thread ( http://bluelight.ru/vb/showthread.php?t=477478 ) most were pessimistic on the possibility of removing the yellow crud with accessible techniques. Today i stumbled upon a procedure for cleaning up JWH-073 (should work for JWH-018), after observing that the 5mg of JWH-073 that i attempted to dissolve in 2.5ml of ethanol was clean white, when before it was a sickly yellow.
1) 98mg of JWH-073 was placed in a 1 dram vial with 1.5ml of 95% ethanol (Everclear). A small lab spatula was used to break up the clumps of the JWH-073.
2) The vial was capped, swirled, and placed in a warm location, and periodically shaken.
3) When the powder was white and free of yellow specks (10-15 minutes), the vial was cooled in a refrigerator for 30 minutes (to precipitate out as much JWH-073 as possible; no yellow precipitate was observed).
4) The ethanol was separated, and the now clean white JWH-073 rinsed with approx 0.5ml of cold ethanol.
5) Purified JWH was rinsed out of the vial onto a glass plate with cold ethanol, and the solvent evaporated.
Yield was 62 mg of an odorless white powder.
The poor recovery was due at least in part due to poor technique and setup in the last step - the JWH was difficult to rinse out of the vial, and some was also lost while handling the glass plate. I saved the yellow ethanol in a weigh'ed vial, so once the ethanol evaporates, i can see how much was lost in the ethanol. Process needs some tweaks, but is imo, quite encouraging.
I am interested in using liquid dosing for JWH compounds (for oral use) - With doses in the sub-10mg range, my milligram scale doesn't cut it. The JWH's however, have been frowned upon by the Gods of Solubility, it seems.
A nice target for solubility would be 10mg/ml (for dosing with droppers or some lovely 1.5ml graduated plastic snap-top vials i have).
Water:
Insoluble, or so close to insoluble that it might as well be.
Ethanol:
JWH-018 - Probably lower than JWH-073 (not tested, but expected from structure)
JWH-073 - <5mg/2.5ml
JWH-250 - >10mg/ml (10mg/ml dissolved within 15 minutes under gentle heat, and didn't precipitate out when returned to room temperature)
Vegetable Oil:
JWH-073 - Insoluble
Heptane (no, i wasn't planning on drinking it):
JWH-073 - Poor (based on crude test)
JWH-250 - Poor. Somewhere around the 3-5mg/ml range.
Anyone know of a solvent that's okay to drink that will dissolve JWH-018 or 073 reasonably well, or have suggestions that i should try?
Or any solvents, toxic or not, that dissolve JWH-018/073 reasonably well?
Cleaning JWH-018/073:
Commercial JWH compounds with the napthoyl moiety often come contaminated with an unidentified yellowish contaminant.
I am not sure what this contaminant is, but based on the odor, and knowing that adding the napthoyl moiety is the last step in the preparation of JWH-### compounds, it stands to reason that it is some naphthalene derivative - it can't be a good thing to get into our body.
I asked about this in an earlier thread ( http://bluelight.ru/vb/showthread.php?t=477478 ) most were pessimistic on the possibility of removing the yellow crud with accessible techniques. Today i stumbled upon a procedure for cleaning up JWH-073 (should work for JWH-018), after observing that the 5mg of JWH-073 that i attempted to dissolve in 2.5ml of ethanol was clean white, when before it was a sickly yellow.
1) 98mg of JWH-073 was placed in a 1 dram vial with 1.5ml of 95% ethanol (Everclear). A small lab spatula was used to break up the clumps of the JWH-073.
2) The vial was capped, swirled, and placed in a warm location, and periodically shaken.
3) When the powder was white and free of yellow specks (10-15 minutes), the vial was cooled in a refrigerator for 30 minutes (to precipitate out as much JWH-073 as possible; no yellow precipitate was observed).
4) The ethanol was separated, and the now clean white JWH-073 rinsed with approx 0.5ml of cold ethanol.
5) Purified JWH was rinsed out of the vial onto a glass plate with cold ethanol, and the solvent evaporated.
Yield was 62 mg of an odorless white powder.
The poor recovery was due at least in part due to poor technique and setup in the last step - the JWH was difficult to rinse out of the vial, and some was also lost while handling the glass plate. I saved the yellow ethanol in a weigh'ed vial, so once the ethanol evaporates, i can see how much was lost in the ethanol. Process needs some tweaks, but is imo, quite encouraging.
