DAT/NAT releasing agents vs. reuptake inhibitors

[StaySedated]

what are the main difference in effect between RA's and RI's?

releasers like amphetamine/meth, propylhexedrine, etc. and reuptake inhibitors like cocaine and ritalin are both euphoric stimulants, but ri's only seem euphoric snorted while ra's are euphoric oraly and snorted.

 

[<pyridinyl_30>]

Cocaine and ritalin are also euphoric when injected or inhaled.

 

[rickolasnice]

Releasers cause monoamine release while reuptake inhibitors inhibit their reuptake

 

[atara]

what are the main difference in effect between RA's and RI's?

releasers like amphetamine/meth, propylhexedrine, etc. and reuptake inhibitors like cocaine and ritalin are both euphoric stimulants, but ri's only seem euphoric snorted while ra's are euphoric oraly and snorted.

RIs could theoretically be euphoric orally, you'd just have to parachute a crazy amount. The difference is just that releasing agent = more dopamine, and that insufflation = faster onset and higher bioavailability.

Coca tea is kind of a better coffee, shame it's illegal.

 

[StaySedated]

i like RA's better. amphetamines are more euphoric, stimulating, and longer lasting either oral or snorted. coke and ritalin just feel weaker anyway i take them(esp. ritalin). also their short duration often leads to compulsive redosing and fiending for more.

RI's also seem to have a worse comedown, even oraly(oral ritalin comedown is much worse than oral adderall, and dosen't provide as good a high). i wonder why this is...

 

[StaySedated]

Releasers cause monoamine release while reuptake inhibitors inhibit their reuptake

i know that, i was talking about effects not mechanism of action.

 

[rickolasnice]

^ Ye sorry post was unhelpful crap..

 

[Turing Machine]

I think it's a mistake to say cocaine isn't orally active because it is a reuptake inhibitor. The main reason for cocaine's reduced oral activity is because of low oral bioavailability. Coca liquors, and buccal absorption of cocaine are quite pleasant. Freud's favorite method of ingesting cocaine was oral.

 

[dread]

The main reason for cocaine's reduced oral activity is because of low oral bioavailability.

I thought it was first-pass metabolism?

 

[pofacedhoe]

coca tea is far stronger when sipped and let to absorb through the lining of the mouth, the same is true of poppy tea (far stronger sipped than gulped). must be directly hitting the bloodstream.

dopamine releasers are more powerfull at producing dopamine and make you feel rewarded by everything, whereas with dopamine reuptake inhibitors there is still the fact you have to be doing something to cause a release to inhibit uptake, if what you are doing is more fun the the amount of dopamine reuptaken will be much higher leading to greater euphoria.

 

[pharmakos]

I thought it was first-pass metabolism?

first-pass metabolism is a cause of decreased oral bioavailability.

 

[Psychedelic Jay]

coca tea is far stronger when sipped and let to absorb through the lining of the mouth, the same is true of poppy tea (far stronger sipped than gulped). must be directly hitting the bloodstream.

dopamine releasers are more powerfull at producing dopamine and make you feel rewarded by everything, whereas with dopamine reuptake inhibitors there is still the fact you have to be doing something to cause a release to inhibit uptake, if what you are doing is more fun the the amount of dopamine reuptaken will be much higher leading to greater euphoria.

This is why cocaine is best with sex.