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Is acetone viable for use in acid/base converstions?

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psood0nym

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Can acetone be used in place of water as a medium for acid/base conversions, or vice versa, with aMT freebase and DPT HCl using citric acid monohydrate and sodium hydroxide respectively as the converters i.e. will it chemically react with any of them in a way that’s dangerous or degrades the psychoactive compounds?

If not, for future reference, is there any recreational compound that would have these problems with acetone?

Thanks guys

*I ask because I’m thinking about attempting a convenient way to get ready to vaporize DPT freebase without having to do pulls from water that can be done with single doses in a few minutes. Basically it’s just doing the conversion and evaporation in a little tinfoil divot. I want to convert some aMT freebase for injection, too, as my HCl is getting low. I assume "pure" acetone is genuinely pure and will evaporate cleanly. Please disabuse me of this belief if this isn’t the case.
 
Never assume when working with store bought solvents. Always evaporate a bit first to check the purity - oils and shit in your product is no fun.

Acetone is probably way too nonpolar for use as a polar layer. Methanol would be more what you'd want for faster evap times than water.

If you are unconcerned with the presence of salts in the final product (e.g. if vaporizing) then you can avoid doing an acid/base conversion and simply add 1 part of either acid or base in as little solvent as needed to convert freebase to salt and vice versa.
 
Nope, αMT freebase is soluble in acetone while it's salts are practically not. Furthermore will there be reaction to the respective imine. This happens not really fast at room temperature, but such a derivatisation is not unlikely. If you work fast, this side-reaction shouldn't pose a problem.

I assume "pure" acetone is genuinely pure and will evaporate cleanly.
Click to expand...
Errrrrr ... yes, pure acetone is pure. If not, it wouldn't be called 'pure'. ;)


Peace! - Murphy
 
I was hoping to just do the molar calculations and mix the DPT and sodium hydroxide together dry, add as much methanol as needed to dissolve both, and then evaporate it, leaving me with DPT freebase in the tinfoil without need for any kind of reconstituting on leaves or whatever. Will this work they way I'm hoping it will or not?
 
Any further clarification on this would be interesting, in the name of science.
 
Acetone undergo "Acid-catalyzed Aldol Condensation" in the presence of strong acids!
(Base environment also catalyse this in the different mechanism)

which then yeild, phorone, isophorone, diacetone alcohol along with (yellow gummy) oligomers.
 
if quick and dirty freebasing is required just mix the salt well with sodium bicarbonate and then vapourise, the sodium bicarbonate will react as soon as the salt melts, freebasing the material. probably a whole lot safer than fucking around with methanol or smoking acetone condensation products, I would expect the beta carboline condensation product of AMT to have quite a bit of toxicity.

this is from memory so might not be 100% accurate.....
acetone was used in the past to manufacture alpha ethyl tryptamine back when it was legal and lead to 20% be carboline impurity.
acetone was also suspected of involvement in creating the toxic impurity in japanese manufactured tryptophan that lead to tryptophan being banned from sale in the US.
 
^Thanks. I guess that could work with DPT HCl for smoking. Is methanol something to worry about if I use it to make aMT citrate from aMT freebase then evaporate? Again, I'd like something suitable for IM injection and I'd be using lab grade methanol. I've definitely abandoned any plans to use acetone thanks to the advice of you and others.
 
psood0nym said:
^Thanks. I guess that could work with DPT HCl for smoking. Is methanol something to worry about if I use it to make aMT citrate from aMT freebase then evaporate? Again, I'd like something suitable for IM injection and I'd be using lab grade methanol. I've definitely abandoned any plans to use acetone thanks to the advice of you and others.
Click to expand...

why bother with evaporating anything when making a solution for IM, add slight excess citric acid to a suspension of AMT freebase in water stir until it dissolves, adjust the pH to about 6-7 using sodium bicarbonate or hydroxide, filter through a micron filter, voila a solution of AMT citrate in sterile water. you are going to have to dissolve it in water in any case so why bother making solid citrate salt.
 
^That's what I've been doing with DMT freebase when I IM, but with vinegar. The reason I want to convert is simple convenience. I don't put in sodium bicarbonate because of the "volcano effect" when mixing it with vinegar. I just add extra water, which makes it pretty a pretty large volume to IM. Obviously that's not an issue if I'm using citric acid with the aMT, but the other advantage is that aMT citrate will degrade more slowly than freebase, or so I've read.
 
The best method to get freebase DTP from HCL , using NaOH would be...?
 
Add a small amount of methanol (or water) to the DPT HCl, enough to dissolve it. Now add an equimolar amount of sodium or potassium hydroxide, shake, and evaporate the methanol (or water) off. You should be left with DPT freebase and salt. If you want to take the salt out, wash your dried product with acetone (or other nonpolar), pool the washes and evaporate the acetone off to yield pure DPT freebase. The stuff that's left behind is table salt that you can throw away.
 
To answer the original question , MeOH is immiscible with hexane and cyclohexane. Might be a useful polar/nonpolar combo
 
sekio said:
Add a small amount of methanol (or water) to the DPT HCl, enough to dissolve it. Now add an equimolar amount of sodium or potassium hydroxide, shake, and evaporate the methanol (or water) off. You should be left with DPT freebase and salt. If you want to take the salt out, wash your dried product with acetone (or other nonpolar), pool the washes and evaporate the acetone off to yield pure DPT freebase. The stuff that's left behind is table salt that you can throw away.
Click to expand...
Great. Thanks a lot. Thanks to everyone else for your input as well.
 
oven goes down to 70 C

water evaps at 100 so i guess there is some luck there
 
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