Opioids Defeating the new OC time release

[puffj]

^It's not like most of us get a choice in which brand we get. We're buying off the street or off of people that might not have Ethex brand at their pharmacy. Dealers don't really take requests.

Knowledge is power.

 

[TheTuneOfTurbo]

i mean, i read the whole thread and i see no solution. what am i missing?

Exactly! MY Solution...

Okay so here's my "solution" to defeating the new OC time release....

A)- Become a chemist and take the time to extract the oxy out of the pill (highly unlikely for most users...)
B)- Just switch to something like Opanas or Roxies.

I think if there was a simple solution that doesn't take time or chemistry knowledge we would've already known about it. I'm coming to the conclusion that we might just have to accept defeat on this one for now. It's sad to realize but hey, there's always other shit out there, so with that being said....touche' Purdue, touche'.

 

[hale]

a lot of oxycodone has been wasted trying to crack this formula, i can tell you that

 

[leigh4oc]

hey, do you know if the generic's say "OC" on them? calling Walgreens now people

 

[leigh4oc]

PuffJ- please tell me asap- do you know what the generics look like? do they say OC 80 on them or no. just called walgreens...they only carry Tiva brand and Melekroi or something????

 

[BigKMeezy]

PuffJ- please tell me asap- do you know what the generics look like? do they say OC 80 on them or no. just called walgreens...they only carry Tiva brand and Melekroi or something????

I just called wallgreens in california and they said bullshit there are no generics..

I think the ethex thing is total BS.

 

[TheTuneOfTurbo]

PuffJ- please tell me asap- do you know what the generics look like? do they say OC 80 on them or no. just called walgreens...they only carry Tiva brand and Melekroi or something????

mallinckrodt? Here's a pic I've got of someone who got the mallinckrodt 80 generics 2 weeks ago. Hope this helps,

http://i57.photobucket.com/albums/g236/nickaanderud/100_0068_0.jpg

EDIT: Also I've got a link with some information about any new generic oxycontins.
http://www.pharmer.org/search/google/generic%20oxycontin?query=generic%20oxycontin&cx=000158012054097468402%3Ap-9mhlbf9va&cof=FORID%3A11&sitesearch=#934

 

[Aloric]

^In the meantime, I think taking a finely crushed oral dose with boosters is probably going to be the way to go... White grapefruit eaten 20 min or so before the crushed pill is taken should help things considerably in terms of speed of absorption, as could many other things. I think white grapefruit and maybe a small, fatty meal will be the best bets from my personal experience, though.

In regards to the the July 2005 withdrawal of Purdue's Palladone extended release capsules (Hydromorphone HCL) in order to reformulate the chemistry- introducing a 'new' XR incantation.

I'm reminded of a post in which the guys' pharmacist appeared to harp excessively not to take ANY alcohol with the new OP Oxycontin formula...

Likely coincidence.. EtOH with narcotics is ALWAYS a Contraindication.. .

Nonetheless, along with the well reviewed dose-dumping from: fatty meals and white gfj... who the hell knows. I can't imagine them going back to this matrix given the FDA heat they got only a year after Palladone's approval. But Ehh!

The 2005 July 15 article excerpt... [pls note, I don't use alcohol and would advise common sense. Alcohol is a well known opiate dose-dumper and concomittant use CAN be Fatal. Use common sense fuh christ' sake. Thanks.

"According to the FDA news release, "Palladone is a once-a-day pain management drug containing a very potent narcotic. New data gathered from a company-sponsored study testing the potential effects of alcohol use shows that when Palladone is taken with alcohol the extended release mechanism is harmed which can lead to dose-dumping."

 

[phr]

This thread isn't about generics. Find an existing thread or start a new one about generics if you want.

If you go off topic your post will be edited or will get unapproved.

 

[leigh4oc]

hey tune of turbo- thanks a lot ! it helped...unfortunately no good tho :-( trying the MEK tomorrow!

 

[TheTuneOfTurbo]

hey tune of turbo- thanks a lot ! it helped...unfortunately no good tho :-( trying the MEK tomorrow!

No problem, just trying to help people find better solutions to their "problems" without them having to experiment around with chemicals and all that mess. A-it's a waste, B-you never know, if you do it wrong you might end up sniffing up a soaking pile of acetone or MEK and I'm sure that can not be good.

 

[syndeusys]

PuffJ- please tell me asap- do you know what the generics look like? do they say OC 80 on them or no. just called walgreens...they only carry Tiva brand and Melekroi or something????

The particular walgreens you called might only have teva and mallinkrodt on hand but most walgreens carry ethex the ethex tablets say OC on one side and 80 on the others just like the old purdue version

 

[syndeusys]

I just called wallgreens in california and they said bullshit there are no generics..

I think the ethex thing is total BS.

Many pharmacies are instructed not to tell patients over the phone what their stok of schedule 2 medications are in order to prevent robberies there are generics and they most likely do have them

 

[Aloric]

mallinckrodt? Here's a pic I've got of someone who got the mallinckrodt 80 generics 2 weeks ago. Hope this helps,

http://i57.photobucket.com/albums/g236/nickaanderud/100_0068_0.jpg

EDIT: Also I've got a link with some information about any new generic oxycontins.
http://www.pharmer.org/search/google/generic%20oxycontin?query=generic%20oxycontin&cx=000158012054097468402%3Ap-9mhlbf9va&cof=FORID%3A11&sitesearch=#934

FDA approved OxyContin in 1995; hits U.S. market early 96' and shoots to #1 selling non-generic narcotic analgesic by 2001.
Note: oxycodone is formulated as single ingredient products or compounded (i.e with APAP). The Compound products are both generic and brand name.

OxyContin is Purdue Pharma's BRAND-NAME for time-release single-ingredient oxycodone oral medication. The manufacturing rights to time-released GENERIC oxycodone are still under dispute... Mundipharma DISTRIBUTES (only) OxyContin in Australia, China, and Europe.

Purdue has many patents protecting its right to be the sole MANUFACTURER of time-release oxycodone, i.e."OxyContin". U.S. Appeals Courts in June 05' ruled unfavorably on Purdue's numerous patents for Oxycontin:

1. Endo Pharmaceuticals says it will immediately make a generic 'OxyContin' in the four main strengths. YET...

2. Purdue already had negotiated with another pharmaceutical company (IVAX Pharmaceuticals) to distribute their brand OxyContin in a generic form... the agreement went to crap...Watson becomes U.S. distributor of Purdue-manufactured OxyContin GENERIC tablet versions- 10mg, 20mg, 40mg, 80mg, in Oct 2005.

3. But Feb 2006 a U.S. Circuit Court of Appeals vacates the earlier ruling.
Purdue's infringement suits vs Mallinckrodt, TEVA, Endo is such:
Endo and TEVA agreed and ceased manufacture GENERIC OxyContin by end of 06'. IMPAX has a temporary license from Purdue, likely renewable 2007.

4. 2008, Mallinckrodt Pharmaceuticals 'reintroduces' GENERIC OxyContin in the strengths of 10 mg, 20 mg, 40 mg and 80 mg, which was made possible by a temporary royalties-bearing license with Purdue Pharma that EXPIRED in 2009.
Right now, Purdue is OxyContin's only maker, baker, candlestickfaker..

Uhh- ALSO- people, States (VA, KY, NY, etc) and Governments everywhere are suing Purdue for misleading consumers on OxyContin's side effects, mislabeling the brand, Executives lying, and basically, a whole bunch a' no-no crap.

 

[TheTuneOfTurbo]

FDA approved OxyContin in 1995; hits U.S. market early 96' and shoots to #1 selling non-generic narcotic analgesic by 2001.
Note: oxycodone is formulated as single ingredient products or compounded (i.e with APAP). The Compound products are both generic and brand name.

OxyContin is Purdue Pharma's BRAND-NAME for time-release single-ingredient oxycodone oral medication. The manufacturing rights to time-released GENERIC oxycodone are still under dispute... Mundipharma DISTRIBUTES (only) OxyContin in Australia, China, and Europe.

Purdue has many patents protecting its right to be the sole MANUFACTURER of time-release oxycodone, i.e."OxyContin". U.S. Appeals Courts in June 05' ruled unfavorably on Purdue's numerous patents for Oxycontin:

1. Endo Pharmaceuticals says it will immediately make a generic 'OxyContin' in the four main strengths. YET...

2. Purdue already had negotiated with another pharmaceutical company (IVAX Pharmaceuticals) to distribute their brand OxyContin in a generic form... the agreement went to crap...Watson becomes U.S. distributor of Purdue-manufactured OxyContin GENERIC tablet versions- 10mg, 20mg, 40mg, 80mg, in Oct 2005.

3. But Feb 2006 a U.S. Circuit Court of Appeals vacates the earlier ruling.
Purdue's infringement suits vs Mallinckrodt, TEVA, Endo is such:
Endo and TEVA agreed and ceased manufacture GENERIC OxyContin by end of 06'. IMPAX has a temporary license from Purdue, likely renewable 2007.

4. 2008, Mallinckrodt Pharmaceuticals 'reintroduces' GENERIC OxyContin in the strengths of 10 mg, 20 mg, 40 mg and 80 mg, which was made possible by a temporary royalties-bearing license with Purdue Pharma that EXPIRED in 2009.
Right now, Purdue is OxyContin's only maker, baker, candlestickfaker..

Uhh- ALSO- people, States (VA, KY, NY, etc) and Governments everywhere are suing Purdue for misleading consumers on OxyContin's side effects, mislabeling the brand, Executives lying, and basically, a whole bunch a' no-no crap.

That's what I call an informative and great post my friend! This is definitely some useful information. Thanks!

 

[puffj]

and thats precisely what we did inthebOx...thank u very much lol

The ethex OC's are made by purdue, they are purdue OC's, more info on this can be found through-out the thread, but if you can't read the thread, do a search of my posts. Because the ethex OC's *are* purdue OC's (literally, purdue gave a percentage of their OC's to ethex), they do say "OC" and "80" on them.

To those thinking the ethex thing is crap, we have had a pharmacist and several personal accounts confirm that the ethex brand is being recently stocked by walgreens, that the ethex brand has the exact same ingrediants as the purdue oc's, and that the ethex oc's *are* the purdue oc's.. of course this shouldn't be surprising since ethex get's their oc's from purdue and pays purdue a royalty.

edit: http://www.drugs.com/pro/oxycodone-er.html

From that link, there is info on the ethex generics. The important info is as follows and can be found on that page:

Product Characteristics Color green (green) Score no score Shape ROUND (ROUND) Size 11mm Flavor Imprint Code 80;OC Contains

Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NDA authorized generic NDA020553 09/25/2009

Labeler - Ethex Corporation (615424686)
Registrant - Purdue Pharma L.P. (932323652) Establishment
Name Address ID/FEI Operations
Purdue Pharmaceuticals LP 132080875 MANUFACTURE
Revised: 09/2009Ethex Corporation

 

[puffj]

the real question is why,

so perhaps the new formula was a way to get the FDA off their back while they use Ethex as a company to still distribute the old formula and still make tons of money and not lose any of their profits,stock prices and market share to other narcotic pain meds.

thats the only explanation i can personally come up with.

and for prudue its a smart move...

Purdue had to do something, the FDA was all over them and they couldn't continue selling the abuseable OC's with the FDA and public pressure killing them. Not to mention the lawsuits. Purdue has been developing this new formula since well before the deal with ethex was struck. Purdue probably made the deal with ethex because they knew they would lose a lot of money in replacing the abusable form of OC with these OP's, so to safeguard against losing all their profits, they allowed another company who wasn't taking heat from the FDA to distribute their product for them. Ethex pays huge royalties to purdue, though because purdue is a private company no one knows how much. If I had to guess though, it's probably an enormous amount. This way purdue continues to make money off of their old OC formula for the foreseeable future. Purdue wasn't about to kill their golden goose, so they safeguarded. But the moral of the story is that the OC's distributed by Ethex *ARE* brand-name old-formula OC's. I just don't understand why most of the people on this forum can't understand this. The ethex's aren't really generics, they are the purdues, and purdue is going to continue to keep making money off of them. The ethex's are the purdue's made in the same factory, made by purdue, and if you ran them through a GCMS they would be identical. Purdue literally made their own OC's and gave 100% of them to ethex.

If people still are trying to "crack the OP's", then I give up, I don't know why you would try to crack a POS pill when you don't have to. The old purdue oc's are still around, just under the ethex name, and will continue to be for way cheap. There is no point trying to break the OP's because the old OC's haven't gone anywhere, they just aren't being distributed by purdue anymore.

btw, ethex will not be distributing purdue's "OP" formula for purdue. This is because the OP's are under a new patent and doing so would violate that patent. So ethex will keep selling the old OC's for purdue and will not "switch" to a new version of the pill ever, because they aren't legally allowed to.

Case closed.

 

[syndeusys]

Exactly what i thought, great post.

Now about the Generic thing, according to pharmacies, they are listed as Generics from my understanding, but in reality they are NOT, but to a price point they are cheaper and considered "generic"

It's called a clone drug all brand name manufacturers do it withbsome of their medications to maintain a larger market share once there patent runs out. The are substantially cheaper through insurance depending on coverage anywhere from $15 to several hundred depending on your plan. As far as cash is concerned they are about 40% cheaper. Since phrozen said no more generic talk from here on out I will only be providing information relating to the new purdue version if anyone wants anymore information on generics be it availability or mg being produced or ingredient listings for ethex or other generics PM me I'm more than happy to anwser any and all questions but we've to respect the mods. Puffj is also extremely knowledgable if you guys want we could start a thread just for this sort of crap if that's the case let me know I'll try and gather everything we've got so far and consolidate it into a more concise bullet point sort of format.

 

[syndeusys]

I had an idea as far as I know drugs with a proprietary delivery system such as Oxycontin especially with the whole new abuse-proof formulation need to have filed a patent with the patent office. I don't really know anything about how patents work but I do know that you can search through all of them (well possibly not all but a whole lot) on http://www.google.com/patents i did a real quick search on "Oxycontin" and sorted by date newest to oldest they have 4 patents just for this year alone if people want to start scouring over these and posting relevant parts here then we should be able to form a fairly straight forward series of experiments that we believe will solve this problem instead of just blindly trying anything we can think of. I'll start my search tomorrow hopefully this will generate some enthusiasm in what has so far been relatively disappointing. Go Team!

I apologize for my grammar it is always awful.

 

[intheb0x]

I had an idea as far as I know drugs with a proprietary delivery system such as Oxycontin especially with the whole new abuse-proof formulation need to have filed a patent with the patent office. I don't really know anything about how patents work but I do know that you can search through all of them (well possibly not all but a whole lot) on http://www.google.com/patents i did a real quick search on "Oxycontin" and sorted by date newest to oldest they have 4 patents just for this year alone if people want to start scouring over these and posting relevant parts here then we should be able to form a fairly straight forward series of experiments that we believe will solve this problem instead of just blindly trying anything we can think of. I'll start my search tomorrow hopefully this will generate some enthusiasm in what has so far been relatively disappointing. Go Team!

I apologize for my grammar it is always awful.

great idea... found this.

"What is claimed is:
1. A sustained-release pharmaceutical formulation, comprising a melt-extruded blend of a therapeutically active agent, one or more hydrophobic materials selected from the group consisting of alkylcelluloses, acrylic and methacrylic acid polymers and copolymers, shellac, zein, hydrogenated castor oil, hydrogenated vegetable oil, and mixtures thereof; and one or more hydrophobic fusible carriers which provide a further retardant effect and selected from the group consisting of natural or synthetic waxes, fally acids, fatty alcohols, and mixtures thereof, said hydrophobic fusible carrier having a melting point from 30 to 200° C., said melt-extruded blend divided into a unit dose containing an effective amount of said therapeutically active agent to render a desired therapeutic effect and providing a sustained-release of said therapeutically active agent for a time period of from about 8 to about 24 hours."

http://www.google.com/patents/about?id=nyTSAAAAEBAJ&dq=oxycontin

and heres the one for the new gelling agent.

http://www.google.com/patents/about?id=T_zRAAAAEBAJ&dq=oxycontin