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Novel Fentanyl Analogue

Everything you come in contact with after this is a Bio-hazard.... Period.

I can understand 2-10 times stronger than morphine, but something in the thousands?
Yes this will be the bomb if it hit the streets, but would you be the asswipe to test a supposedly proper cut batch? I MOST CERTAINLY THINK NOT!!!!!!!!!!!!!

If you do the math, you will need tons of baby laxative to cut a 10g sample of this.

The nickname on the street will be " Lil' Overdose" "Suicide" "Life-Stopper" I can think of hundreds...

You'd have to be near death tolerant to use this...

There is just no way this is practical.

Damn chemist, always getting excited to make a impossibly potent poison.

A couple of grams could get a town of fiends wasted.
 
Nah! No need to exaggerate the danger of this compound. Of course it's a chemical weapon - no doubt about that, but the effort and skill needed to synthesize either the racemic compound or the correct eutomer is far beyond the capability of most people around. 3 Stereoisomers are not a triviality to prepare. (fortunately, in this case)

This is all chemical masturbation. Calling it "21,334 times more effective than morphine" is downright pointless. There is no way to predict such a number. Even though - it is well known that potency does not equal euphoria or over-all quality of the trip, in particular with opioids.
The ultra-potent fentanyl-analogues are all either tools for anaesthesia in the hands of a professional or for homicide/suicide in the hands of a layman.


*yawn* Just another splendid idea that lowers the S/N-ration in ADD. I can't see anything useful coming out of this particular thread.


- Murphy
 
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fryingsquirrel said:
How does one come up with such specific a number for a drug that exists (so far as I know) on paper?
Click to expand...

I won't know for sure until after I take pchem/biochem, but perhaps it's a comparison between binding affinities to the receptor, etc?

Even still, there's so much other stuff to take into account that it would mean months of computation on a super computer.
 
if only it was as simple as this,
step 1 putting a structure like fentanyl into chemdraw obtaining some calculated value like molar refractivity or boiling point (yes it is as sensible)
step 2 dividing the known potency by the value from chemdraw, to give potency per molar refractivity unit
step 3 inserting new structure into chemdraw and multiplying the answer in step 2 by this
step 4 anounce some breakthrough in drug design with numbers not forgetting to be over precise
step 5 phone Jannsen where a bright future awaits you.

I think the molecule is too lipophillic and too bulky in certain areas to have optimal binding but I know next to nothing about mu agonists.
 
As usual, Vecktor got the best ideas of 'em all. Damn, he is good!

May I help out:
Janssen Pharmaceutica USA: (1+609) 730-20 00
Janssen Pharmaceutica UK: (44+1494) 567 567
 
^ LOL.

And it is not like this is totally a breakthrough.

Not too long ago a certain Fent analogue with an Egyptian motif surfaced and it didn't take long for it to kill several people on BL alone, one of which was a friend of mine.

This whole Fentanyl shit has "bad" written all over it from start to finish.
 
Btw, looking back at this thread, AFAIK no one can tell for sure just what is "pharaohfentanyl" (or perhaps it was identified and I didn't get the news) and it is likely that the descriptions in that thread and others are peppered up at best, but what WAS sure is that blotters with some sort of very potent opioid (I would think some variation of ohmefent.), were distributed by a single person and resulted in a number of fatalities and addictions.
 
LivingOnValium said:
The coolest fentanyl analogue thread ever was started by the user In the Eyes of God. I'm afraid this one can't even touch that classic.

Decide yourself, IMO this should be in the best of BL:

http://www.bluelight.ru/vb/showthread.php?t=302759
Click to expand...
Wow. The part that kills me is that the dude claims to have sourced an obscure fentanyl analog but couldn't find a website that would sell him xanax. Right up there with the guy in PD who had ald-52 but couldn't find distilled water.
 
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There was a bunch of confirmed 3-methylfentanyl in Estonia in 2005-2006

But in the West, a series of things promoted as "China White" hit North America from late 2003 (when something by that name was offered to me in Miami) till about 2007: but I can't confirm that any of what was passed off in the US as China White was anything more than mixtures of heroin and (plain) fentanyl.

Do y'all know if any of the shit that was swirling around this continent back then was actually a fent analogue and not just fent itself? Like, can you link to any North American forensic or toxicology reports from the middle part of this past decade?
 
Indeed, it is not really all that complicated to come up with stuff like this. Rather elementary, in all actuality.

And I will certainly agree that fentanyl derivatives are dangerous drugs in the extreme sense of the word; all that potency means that people taking such compounds will die at some point... not all of them, but some of them for sure.

My interest in all of this is purely intellectual at this point, and probably always will be. I'm not yet sufficiently morally or ethically bankrupt to sell such potentially lethal drugs to anyone else. I might have to admit to being potentially stupid enough to try them on myself, but give or sell these to someone else? No way..

If you must try this, then make it for yourself. It's not that hard to do.
 
cosmotroniks said:
Indeed, it is not really all that complicated to come up with stuff like this. Rather elementary, in all actuality.

And I will certainly agree that fentanyl derivatives are dangerous drugs in the extreme sense of the word; all that potency means that people taking such compounds will die at some point... not all of them, but some of them for sure.

My interest in all of this is purely intellectual at this point, and probably always will be. I'm not yet sufficiently morally or ethically bankrupt to sell such potentially lethal drugs to anyone else. I might have to admit to being potentially stupid enough to try them on myself, but give or sell these to someone else? No way..

If you must try this, then make it for yourself. It's not that hard to do.
Click to expand...

Maybe was not the best idea (I mean posting it here) but there is no too many places where such that info can be given to the people who has legitimate interests on it

The point of making it yourself (if you can, of course), trying it yourself and not dying while doing so, it's the best point.
So no moral or legal concerns about your creation.

There's a Daily Mirror article written where A.Shulgin is shown as the father of hundred of deaths -because of MDMA, just for his words, as he didn't create the material- and instead of pledge forgiveness, he is proud to do what he does.

And nobody here thinks such that nonsense is a point to be considered.
Shit to help the authorities with the war on drugs.

Anyway, I'd rather be very far away of such that thing... at least while it's not sold and double-checked under strict protocols.

One more thing, a 100 mgs dose of diamorphine for non-tolerant users, means something really disgusting to experiment.
I'd say that a good enough dose with the pure chemical is around 20 mgs for a non-tolerant or naive person.

I'm used to that material (not the pure one, but the roughly 50% pure that comes from Afghanistan with several impurities and sub-products by a poor synth) and even with low-tolerance developed -under reduction with the Ott Method using naltreone at the same time at microgram doses- a 100 mgs dose of that material is enough in a single administration for several hours of calmness and being able to keep working.

But for a naive user, that's a bit toooooo much.


One question that I'd like to be answered: in the case of such those extremely potent opioid agonists, what should be the fastest and more intelligent antagonist to use? Naxolone IV? Or is there any stronger antagonist used in such those cases?

Thanks for your time and words.
 
A couple things;

To those asking about what constitutes euphoria, as I understand it, it's not only absolute affinity for the mu receptor, but selectivity over the other opiate receptors. This pattern closely matches ratings given by people with a depth of experience in a wide variety of substances.

Anyone working with fent analogs MUST have a supply of naloxone in prepared syringes, and never be alone- which is SOP for people who handle etorphine/carfentanil. And the proper equipment.

Although it's kinda self limiting... anyone with the ability to get that far into the synthesis is going to be a skilled chemist with the proper equipment, take the proper precautions, and dilute it before selling it to anyone who lacks those. If I had the money for equipment and connections for the precursors, I'd bet my life on my ability to do it safely. If you can't say the same, don't even try.
 
seep said:
There was a bunch of confirmed 3-methylfentanyl in Estonia in 2005-2006

But in the West, a series of things promoted as "China White" hit North America from late 2003 (when something by that name was offered to me in Miami) till about 2007: but I can't confirm that any of what was passed off in the US as China White was anything more than mixtures of heroin and (plain) fentanyl.

Do y'all know if any of the shit that was swirling around this continent back then was actually a fent analogue and not just fent itself? Like, can you link to any North American forensic or toxicology reports from the middle part of this past decade?
Click to expand...

Seep, this link describes the identification of the many fentanyl analogs distributed as china white from orange county in the 70's synthed and in many cases invented by some obviously brilliant and professional chemist in the pre-analog act days. I think the chemist was caught and named by I cannot find the information atm. The guy sounds like a real life "Walter White" from the show Breaking Bad.

http://www.erowid.org/archive/rhodium/chemistry/china.white.identification.html

http://www.erowid.org/archive/rhodium/chemistry/designer.drugs.history.html

I remember a few occasions living in manhattan where brands (often times the most highly demanded brands) would have trouble where 9 out of ten or a higher percentage of bags would be dummies and one out of ten would have the potency of ten bags. Alpha methylfentanyl is considered about 10X the potency of morphine. Obviously the organization would typically switch to a different stamp after such an occurrcnce. I lost an uncle to an incident of this nature and now my cousin will never know his father except from our recollections. Even the weaker fentanyls are bad stuff for recreational users. They're great pain medicines with a very high ratio of pain killing to euphoria. Some of the fentanyls and even some of the Bentley compounds are supposed to also have a massive therapeutic dosage range with high potency for pain treatment but low potency for respiratory depression, at least in animal tests. They represent very useful tools for medicine but the majority of them really have no place in recreational users. Personally I don't see much problem talking about the super potent opioids since anyone with the knowledge and equipment to make them knows that they produce an untreatable level of withdrawal and would not do any self experimentation. The organized criminal groups that would sell potent opioids as heroin are already doing so and one more isn't going to change anything.

This scenario which I remember recurring on at least three occasions implies some highly potent synthetic since the higher the dilution rate the more difficult and problematic a cut becomes, and the fact that one bag could have the potency of ten bags implies that whatever it was was at minimum 5-7 times as strong as pure diamorphine, possibly more which would hint at something like alpha-methylfentanyl or another weaker but longer acting fentanyl or other strong opioid. The fact that the inactive bags had zero activity implies that it was not a mix of heroin and fentanyl and the brand before the problems was able to keep an addict "well" for roughly the same length of time as heroin. Since IV fentanyl presumably cannot keep an addict well for any appreciable length of time, I'd guess something like alpha methylfentanyl, although it's surely not the only possibility. The problems with the cut might have suggested it was something even stronger. I don't know the half lives of 3-methyl and alpha-fluoro fentanyl.
 
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