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  • BDD Moderators: Keif’ Richards

How do benzos compare to other GABAergic drugs?

Anon54

Ex-Bluelighter
Joined
Jun 11, 2010
Messages
861
I seen a girl pick up a script for Soma the other day at the parmacy & was reading how it has similar effects to Benzos.

Do ppl generally consiter Benzos to feel better than Soma?
What about "The Z drugs". How do they compare to benzos?
For me it's OK to have a few Valiums in the morning but would ppl typically do this with Ambian for instance or would it just make ya feel tired?

Here's a list GABAergic drugs from wiki anyways:
http://en.wikipedia.org/wiki/GABAergic#GABAergic_Drugs
For anyone who has tried drugs from this list feel free to give them a rating.

I've never really had to many problems getting scrips for various benzos.
I'm from Australia, wondering if it's difficult to get scipted other drugs that are as calming or even more calming than Benzos.
 
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What you are talking about are drugs which are agonists of GABA (gamma-Aminobutyric Acid). Among these drugs are carisprodol (soma) and benzos. Both are sedatives, but aren't very similar in terms of effect. Soma, at high doses, can cause a lot of disorientation and extreme loss of motor function. The high itself is pleasant for some, but I personally am not a fan.

EDIT: sorry I didn't read that wiki link at first and thought you were asking what GABA drugs are.

Soma can be relatively easy to be RXd. Its a muscle relaxant and is often used for in conjunction with painkillers for use in pain patients. It is very calming and its sedative effects are defiantly noticeable.
 
Soma can be relatively easy to be RXd. Its a muscle relaxant and is often used for in conjunction with painkillers for use in pain patients. It is very calming and its sedative effects are defiantly noticeable.

Yeah I noticed on wiki it said Soma potentiates opiates well.
Just want an idea of the feel of it. Is it more like Xanax, Valium, Alcohol or what?
Does it have a more desireable effect than benzos in most ppls opinions?
 
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No I think the majority of people would chose a benzo over Soma any day. Some is almost dis-associative. Its like you brain your limbs don't respond correctly to what your brain is telling them (at high doses). I've actually been RXd Soma off label for anxiety once. It can be pretty euphoric but the high is nothing like a benzo. Maybe in the aspect of its sedative-ness and keeping you mellow, but toher than that its pretty different. Actually one of those highs that's pretty difficult to describe. Maybe someone else can explain it better
 
Has anyone ever got a script for anything better than there favourite benzo when it comes to GABA agonists?
 
I seen a girl pick up a script for Soma the other day at the parmacy & was reading how it has similar effects to Benzos.

Do ppl generally consiter Benzos to feel better than Soma?
What about "The Z drugs". How do they compare to benzos?
For me it's OK to have a few Valiums in the morning but would ppl typically do this with Ambian for instance or would it just make ya feel tired?

Here's a list GABAergic drugs from wiki anyways:
http://en.wikipedia.org/wiki/GABAergic#GABAergic_Drugs
For anyone who has tried drugs from this list feel free to give them a rating.

I've never really had to many problems getting scrips for various benzos.
I'm from Australia, wondering if it's difficult to get scipted other drugs that are as calming or even more calming than Benzos.
soma: primarily muscle relaxant. has a somewhat drunky feel to it. a little disorienting. more similar to alcohol than benzos. i find it more euphoric than alcohol though, alcohol usually doesn't euphoriate me

alcohol: really messes with coordination and emotions compared to other gaba's, impairs judgement more. though all gaba drugs do this, alcohol seems a little worse here. bad drunks aren't uncommon, emotions can spiral. alcohol can be pretty fun but it's the shittiest drug ever to use daily for so many reasons

benzos: these have the anxiety and sleep and other benefits of alcohol and other gaba drugs, but much more clear-headed

lyrica/neurontin: from what i can see, they seem more similar to alcohol than benzos. they don't seem as clear headed and their effect profile isn't as benign as benzos. they don't seem as recreational as alcohol or benzos, though many do like lyrica/neurontin better than alcohol/benzos, individual preference i guess

Z drugs: these were developed from benzodiazepines. they effect GABA-A like benzos (i think alcy and ghb effect gaba-b, don't quote me). the Z drugs have very similar action, but more mental effect less somatic effect. so they may not be as good relaxing the muscles and body high, but they are great with hypnosis/lulling to sleep and they can be used for anxiety
 
yeah did a bit of reading on wiki
Ethanol binds to acetylcholine, GABA1, serotonin, and NMDA receptors. So it fucks with ya brain in a more of a broad fasion
Benzos are only agonists of GABA1 receptors so they are more specific to relaxation.

Reading about the Z drugs.
they are cross tolerant to benzos & they still use valium to wean ya off em

A study of abuse potential of eszopiclone found that in persons with a known history of benzodiazepine abuse eszopiclone at doses of 6 and 12 mg produced euphoric effects similar to those of diazepam 20 mg . The study found that at these doses which are two or more times greater than the maximum recommended doses, a dose-related increase in reports of amnesia and hallucinations was observed for both eszopiclone (lunesta) as well as for diazepam (Valium).

Eszopiclone (Lunesta) along with other "Z Drugs" including zolpidem (Ambien), zaleplon (Sonata) are the most commonly prescribed sedative hypnotics in the USA
I didn't know that they were more prescribed than benzos in the USA. (Maybe they arn't as euphoric as benzos yet wiki still states they can be as addictive.)

Would most ppl generally consiter Benzos more recreational than the "Z drugs"?
 
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my brother is horribly addicted to zolpidem. i don't understand it

he likes his GABA drugs, alc benzos etc. he snorts zolpidem for the rush and for some reason loves it way too much. he likes it more than the alc and benzos. probably because its a little pseudo-trippier. he tends to drink ..plenty..

the first couple times i did it (scripted for insomnia) i had a pleasant experience or two, 10mg was plenty though 20mg (was curious) produced a sorta-similar-to-trippy effect. after getting a tolerance to benzos it doesn't really do as much recreationally, though i'm sure it'd work if i took several pills. i sleep fine on diazepam and i prefer not to increase benzo tolerance, not worth it with zolpidem
 
I have been Rx'd soo many of the GABA drugsits not even funny, so I'll give you some firsthand experience and knowledge about them, including the amount Rx'd and why.
Alcohol- One of the most widely known GABA related drugs, not much needs to be said about this one.
(60/month) Alprazolam 2mg- I was prescribed Xanax starting at 0.5mg as needed for panic attacks, then over a course of 4 months I moved up to two 2mg bars per day for anxiety and panic. Xanax is one of the more euphoric benzos as it as a shorter half-life than most making it quick and effective for quelling anxiety attacks. Too much alprazolam though and you will have just woken up from what feels like a drunken stupor, only to find out you did a bunch of things you can't remember doing.
(90/month) Carisoprodol 350mg- Soma is a strong muscle relaxant, and a cousin to the strong and popular drug Meprobromate. Soma is an unpredictable drug known to many as depressant crack because of its addicting qualities such as short duration of action, intense high, and a need to always do more. Tolerance builds rapidly, as this is one of the most euphoric GABA drugs out there. Too high of a dose and you will have lost control of your muscle functions and will resemble that of a DXM overdose in many ways.
(60/month) Chlordiazepoxide 25mg - Librium was the first benzodiazpeine to be discovered and is almost like a weaker versoin of Diazepam. It is typically used in the treatment of alcohol and drug withdrawl. It is not used as often anymore due to new and more effective drugs coming out.
(30/month) Clonazepam 2mg- Klonopin is a hit or miss recreational benzo for most people. Some people swear by it and get a good high out of it, while others feel it is weaker than Lorazepam. However it is a great medicine to control seizure disorders as well as an anxiolytic and muscle relaxant. The "high" is a mellow, relaxed sense of well-being.
(90/month) Diazepam 10mg- Valium is a great drug for taking that edge off of everyday life, and provides you with a long acting sense of calm and happiness. In the beginning Valium can be quite euphoric to most. Valium is also one of the best drugs to use for alcohol,barbituate, and benzodiazapine withdrawls, as it can be used for tapers ranging from upwards of 100-200mg all the way down to 1.25-0.5mg.
(30/month) Eszopiclone 3mg- Lunesta is a decent nonbenzodiazepine that is helpful in treating insomnia and does not have much potential for abuse, unlike other hypnotics such as Restoril, Ambien, or Halcion
(60/month) Gabapentin 300mg- Neurontin is a GABA drug similar to lyrica that is used for the treatment of nerve pain, and is pretty effective at helping in fybromyalgia pain. At doses around 1.2g it has potential for abuse, and also potential to help aid in stopping dependency on street drugs in this dosage range.
GHB- although I was not prescribed this one, it is an important GABA drug, and is sometimes rarely Rx'd under the brand name "Xyrem" in the united states. GHB is effective at treating narcolepsy, alcoholism, depression, and other mental illnesses. It has been demonized in the media however as a date rape drug and a club drug, because it shares the amnesiac effects that most GABA type drugs have. GHB is a euphoric drug thought of as comparable to "liquid ecstasy".
(90/month) Lorazepam 2mg- Ativan is a mellow benzodiazepine much like Xanax, but without as much associated euphoria. Ativan is great for Generalized Anxiety Disorder as well as for panic attacks. It is one of the few Benzos that you recieve via IV in a hospital setting, along with Diazepam and Midazolam. Is also a good drug in the use of treating hallucinogenic panic attacks, like the ones that can come from unsettling trips on LSD or mushrooms.
(IV'd/rarely) Midazolam (5mg)- My only exeperiences with Versed are in hospital settings where it was administered via IV in combination with Fentanyl, as part of my sedation for certain procedures. It is the most euphoric benzo I have come across and pairs very well with Fentanyl IV. It is very short acting (about 1 hour) so redosing is needed, and is typically only good for procedures, not day to day activities.
(60/month) Oxazepam 30mg- Serax is great for both coming off of Alcohol and drug use, as well as for a anxiolytic without much potential for abuse. It is a boring benzodiazepine in the recreational sense.
(30/month) Temazepam 30mg- Restoril is up in my top 3 for favorite benzos, along with Xanax and Versed. It is very euphoric, and great for sleeping. In high doses it is one of the few benzos that actually has a "high" to it, not just a calm sense of wellbeing. In the higher doses it will resemble Xanax abuse, with slurred speech and failing motor skills.
(10/month) Triazolam 0.5mg- Halcion is a very potent hypnotic that I use for jetlag and bad flights. It is short acting, and has a lot of amnesiac properties which is also nice for dental procedures. It is abusable, and is very potent.
(30/month) Zolpidem 12.5mg- Ambien is a well known and bizzare hypnotic. It can allow people to get great sleep at night, but it becomes abusable and almost a hallucinogenic when one stays awake for the duration of action. If you fight going to sleep, as little as one Ambien CR will have you in a full-on trip, and not usually a fun one. Be careful with this drug as it is known to make people do wild and reckless things in their sleep including driving, having sex, and eating.

OK well I know that was a really long post but I hope that helped in describing some of the different GABA drugs out there, there are many more those are just the ones I have been Rx'd in the last 3 years. If I had to pick a favorite it would definitely be the shorter acting benzodiazepines.
 
Great post, MDMA. I had a blast reading it. I have tried Ativan, klonopin, and Xanax. I would say although I like any of em, nothin hits the spot like a good ol' sexy white Xanax bar or two
 
thanks, yeah a bar or two can really hit the spot,
but so can a shot of Versed,
or a couple Restoril 30's! :)
 
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I was high and i was bored and was talking to other people besides you, if you dont like em dont look at em. Damn some people on these boards get so self-righteous

*and they are all legally prescribed to me, so what do I care if a cop sees them or not?
 
soma: primarily muscle relaxant. has a somewhat drunky feel to it. a little disorienting. more similar to alcohol than benzos. i find it more euphoric than alcohol though, alcohol usually doesn't euphoriate me

alcohol: really messes with coordination and emotions compared to other gaba's, impairs judgement more. though all gaba drugs do this, alcohol seems a little worse here. bad drunks aren't uncommon, emotions can spiral. alcohol can be pretty fun but it's the shittiest drug ever to use daily for so many reasons

benzos: these have the anxiety and sleep and other benefits of alcohol and other gaba drugs, but much more clear-headed

lyrica/neurontin: from what i can see, they seem more similar to alcohol than benzos. they don't seem as clear headed and their effect profile isn't as benign as benzos. they don't seem as recreational as alcohol or benzos, though many do like lyrica/neurontin better than alcohol/benzos, individual preference i guess

Z drugs: these were developed from benzodiazepines. they effect GABA-A like benzos (i think alcy and ghb effect gaba-b, don't quote me). the Z drugs have very similar action, but more mental effect less somatic effect. so they may not be as good relaxing the muscles and body high, but they are great with hypnosis/lulling to sleep and they can be used for anxiety

Lyrica isn't a GABA agonist. Pregabalin is a structural derivative of GABA, though it does not bind directly to GABAa, GABAb, or benzodiazepine receptors, does not augment GABAa responses in cultured neurons or have acute effects on GABA uptake or degradation. In cultured neurons prolonged application of pregabalin increases GABA transporter protein and increases the rate of GABA transport. It basically mimics the effects of GABA.
 
in my humble opinion/experience... benzos are the most benign and clear headed. only problem is tolerance poking through your daily dose, and dose increases being an unsustainable solution
^ What was the purpose of those pictures? No one gives a fuck what drugs you have except maybe some very bored cop.
well i got a woody
 
I forgot to mention, I prefer Soma over benzodiazepines and Z-Drugs. It could have something to do with my addiction and high tolerance to them but Soma just really relaxes and mild but nicely sedates me.

Down in AZ Soma is a Schedule IV drug and for me I've found it near impossible to be prescribed but benzos very easily. Whenever I've asked for it or just tried to get them the doctor frowns and judges me as a drug addict (which I am) and drug seeker (which I was). I had a doctor who prescribed me Xanax over Soma because he said it was a "strong narcotic".
 
I forgot to mention, I prefer Soma over benzodiazepines and Z-Drugs. It could have something to do with my addiction and high tolerance to them but Soma just really relaxes and mild but nicely sedates me.

Down in AZ Soma is a Schedule IV drug and for me I've found it near impossible to be prescribed but benzos very easily. Whenever I've asked for it or just tried to get them the doctor frowns and judges me as a drug addict (which I am) and drug seeker (which I was). I had a doctor who prescribed me Xanax over Soma because he said it was a "strong narcotic".

I agree with you here, Soma is the shit, I absolutely love it, especially with soma oxycodone and xanax and a beer to wash it all down%)

But yeah down here in FL all the docs will Rx anything to anyone as long as its not schedule II, benzos, soma, hydrocodone, tramadol...then the pill mills are the only ones who really pump out the schedule II's like Roxi, MSContin, Opana and Diluadid
 
I was high and i was bored and was talking to other people besides you, if you dont like em dont look at em. Damn some people on these boards get so self-righteous

*and they are all legally prescribed to me, so what do I care if a cop sees them or not?
There's no HR point to the photos. I went ahead and removed them. :)
 
Kind of off topic, but:

I find the combination of Bupropion (Wellbutrin XL) and Alprazolam (Xanax) to actually be euphoric.

There's something about the (weak compared to amphetamine) Dopamine reuptake inhibition (from Bupropion) + GABA activity enhancement (from Alprazolam) that seems to hit the spot.

Taking the above mentioned drugs together also reduces black outs (I find at least) usually caused by Alprazolam at higher doses.

P.S., the same goes for Bupropion (Wellbutrin XL) and Zopiclone (Imovane) although it's a slightly different high.

To answer the OP's question though,

The only substance I've done that gave me a better high than Xanax (which in my opinion is the must euphoric benzo) would have to be pentobarbital (Nembutal).
 
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