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6-APDB | 6-(2-Aminopropyl)-2,3-dihydrobenzofuran

MeDieViL

MeDieViL

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This compound will be available soon, i beleive someone mentioned that it caused violent vomiting but that it was worth the come up. Does anyone have some more information on that?

(This thread is NOT about 6-APB aka benzo fury (that name's gonna stick around anyway8)) this thread is about 6-APDB a simular but differend compound)
 
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There is another whole thread on this, although it is sometimes refreshing to start a new one. :\

Would be interested in more real experiences, at least this one seems to be selling AS IS, I.e by it's chemical name. Still FAR more interested than these NRG-1, NRG-2, NRG-3-who-know-what-kind-of-god-awful-mix-you'll-receieve-in-the-post-this-time crap.

The only concerning thing though is the HYPE surrounding it.
 
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The other threads are about 6-APB mate, this one is 6-APDB simular but not the same.
 
Brian.Badonde said:
Well for a start its neurotoxic and causes brain damage.
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there is no sound evidence either way.

it could reasonably be expected to cause neurological changes like MDA or MDMA because of the increased cytoplasmic monoamine concentrations and the oxidative stress that results particularly from dopamine.
It seems reasonable to assume that both 6-APB and APDB inhibit VMAT-2 and prevent vesicular uptake of monoamines, essentially all monoamine releasers do.

we also do not know about the metabolism of either compound. the fully aromatic furan would be expected to be metabolised by P450 to a 2-3 epoxy compound. the saturated compound would most likely be metabolised to a compound where the furan ring is opened, some sort of orthohydroxyaldehyde perhaps? All just a wild guess.

the 6-APDB compound has been around in some circles for at least 4 or 5 years.
 
appologies with the confusion, have corrected my post to clarify

I had mistakenly thought all this past discussion was about 6-APDB, agreed 6-ADB far less interesting/novel
 
vecktor said:
we also do not know about the metabolism of either compound. the fully aromatic furan would be expected to be metabolised by P450 to a 2-3 epoxy compound.
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yikes! sounds anything but healthy.
could it be that the furan-ring survives untouched by CYP450, thusly giving it the long duration?
the saturated compound would most likely be metabolised to a compound where the furan ring is opened, some sort of orthohydroxyaldehyde perhaps? All just a wild guess.
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shouldn't it be metabolised to 3-OH-4-hydroxyethyl-amp if it follows the same pattern as mdma (or am i too tired to think clearly tonight ;))?
 
vecktor said:
the 6-APDB compound has been around in some circles for at least 4 or 5 years.
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Recreationally? Are there any "reports", or was this one of the special compounds that more 'connected' people kept hush about?
 
shouldn't it be metabolised to 3-OH-4-hydroxyethyl-amp if it follows the same pattern as mdma (or am i too tired to think clearly tonight )?
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3-oh-4-(2-oxoethyl) is more likely, I think. Even if the alcohol was produced it would relatively quickly be oxidized to the aldehyde.

Which in turn could likely become the carboxylic acid, 3-oh-4-(carboxylmethyl)-amp.
 
dread said:
3-oh-4-(2-oxoethyl) is more likely, I think. Even if the alcohol was produced it would relatively quickly be oxidized to the aldehyde.

Which in turn could likely become the carboxylic acid, 3-oh-4-(carboxylmethyl)-amp.
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ah, yes, you're right. thank you.
looks like a pretty benign metabolic pathway to me.
 
as far as I can determine the nearest compound to 6-apdb which we have good knowledge of the metabolic routes for in man is darifenacin

220px-Darifenacin.svg.png


it is 5 substituted dihydrobenzofuran and it has bulkiness on the nitrogen but it looks to be a useful surrogate.

Darifenacin is extensively metabolized by the liver following oral dosing.

Metabolism is mediated by cytochrome P450 enzymes CYP2D6 and CYP3A4. The three main metabolic routes are as follows:
monohydroxylation in the dihydrobenzofuran ring;
dihydrobenzofuran ring opening;
N-dealkylation of the pyrrolidine nitrogen.

The initial products of the hydroxylation and N-dealkylation pathways are the major circulating metabolites but they are unlikely to contribute significantly to the overall clinical effect of darifenacin.
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with the aromatic 6-APB there are a few possible surrogate compounds that can give us an idea about metabolism, the suggestion is that the 2-3 double bond might be oxidised to a reactive 2-3 epoxy compound, fortunately 6-APB is excreted pretty quickly and metabolised elsewhere in the molecule.

The pharmacological profile of both compounds suggests that like MDA frequent repeated use is not a good idea and If bluelight is serious about harm reduction rather than just acting as an advertising forum for vendors and a sourcing forum for users , that message needs to be communicated Right now in another sub-forum on this board we have a moderator posting binge reports (sorry scientific research) by every ROA he can think of I think this does not fit with the purpose of this board. There are already reports of people attending A and E due to 6-APB ingestion.
 
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vecktor said:
The pharmacological profile of both compounds suggests that like MDA frequent repeated use is not a good idea and If bluelight is serious about harm reduction rather than just acting as an advertising forum for vendors and a sourcing forum for users , that message needs to be communicated Right now in another sub-forum on this board we have a moderator posting binge reports (sorry scientific research) by every ROA he can think of I think this does not fit with the purpose of this board. There are already reports of people attending A and E due to 6-APB ingestion.
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It has been suggested to me that influential BLer's are first on the list for free samples. I do not care how good or bad the substance is that thread should go into a new sub forum called Shill Reports.
 
gannetsarewe said:
It has been suggested to me that influential BLer's are first on the list for free samples. I do not care how good or bad the substance is that thread should go into a new sub forum called Shill Reports.
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A lot of influential Bluelighters already are private chemists or know private chemists themselves and don't have to resort to getting free samples of new compounds from random vendors posting on this forum.

The rest are just random people who post here...
 
nuke said:
A lot of influential Bluelighters already are private chemists or know private chemists themselves and don't have to resort to getting free samples of new compounds from random vendors posting on this forum.
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But many are not and know not and may.
 
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testing

two different samples from two different suppliers: both suppose to be 6-apdb

testing results:
APDB-1
74,22% alfa-Pirrolidinopropiofenona
9,74% pirrolidinoefedrina
2,30% metanol
rest gypsum

APDB-2
98% 4-Metiletcatinona


be careful!!!!
 
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