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Antacid before rolling query

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losthippy

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Jan 23, 2010
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I've read in a couple of posts that MDxx pills taken orally are degraded to some degree by stomach acid. The suggestion is to dose first with an antacid. I always chew and drop pills on an empty stomach so I imagine my stomach acid would be fairly strong and might destroy some of the ingredients before they had time to do their thing. Is this a fair call? Would taking an antacid allow for more complete absorbtion of the pill?
 
I think what you're eluding to is Cimetidine, an H2-receptor antagonist [second generation antihistamine].

It inhibits the production of the P450 enzymes, which would result in high blood plasma concentrations of MDxx.
This can be dangerous as Cimetidine affects a whole load more drugs than just MDxx..

More to the point if you want avoid degradation by stomach acids etc. then maybe try crushing the pills and swallowing them inside enteric-coated capsules (they don't break down until the small intestine)..
 
stigma said:
Where would one acquire enteric-coated capsules?
Click to expand...

One would presume to find them in the same places one would be finding regular hard-shell gelatin capsules..
So eBay, Health food/supplement shops etc..

EC is the abbreviation sometimes used..
 
Your stomach acid won't harm the MDMA molecule, so no need to worry there.

Changing the pH (acidity) of your stomach might have some affect on how quickly the drug is absorbed, but I've played around with it quite a bit (adding both antacids and acids to the mix) and could never tell a difference.
 
It has to deal with your digestive system/how quickly your kidneys filter the drugs out of your system. This topic is dealt with on adderall forums allthe time but also applies to Mdma.
Just look up adderall potentiators on google. The reasoning behind the ph regarding adderall is the same with MDMA
 
So......... if you take either immodium or tums before you roll, it wont make much of a difference on how hard, or weak, you roll?

I have heard of someone on PR preloading on about 5000mg of vitamin c [crazy!] and consuming a pill. Said that it kicked in a lot sooner, and someone commented that it was because of his stomach being more acidic due to the vitamin c.

If that's true, then couldnt preloading on immodium or tums make it do something similar?
 
take a 1/2 a teaspoon of baking soda mixed in a cup of water about 10 minutes before you drop (mix some sugar to cover the taste if you want)
that amount successfully raises my ph for my adderall meds. Keeps the amps in my system longer for my body to absorb.

I personally don't recommend tums. The few times I have tried them for adderall (instead of baking soda) it has made me queasy. Don't know if this is the same with MDMA, but I would assume so.
 
I've taken both vitamin C and imodium before/during, and neither seemed to have much effect on the potency/duration of the roll. Imodium is a great choice for preventing diarrhea that occurs with the comeup, as well as some of the nausea that results from over-excited intestines. (If that's a problem for you).
 
I had a remgel after my last meal today which was around 4 o clock, i dropped at 12 and havent suffered the nausea that usually succumbs in the come up, yet i also smoked a joint of cannabis to help with this ;) Hope ths helped. Peace.
 
misterpicky said:
No, it doesnt, but like I said, wouldnt it really make your stomach acids more acidic and break down the pills quicker? NOT make it stronger, but make it kick in quicker.
Click to expand...

This acidity may degrade the substace quicker,
More poignantly Vit C is a Reducing agent (hence=antioidant)
this is more likely to have a neffect ..
 
If you want to make yours hit harder and longer just don't eat at least 5 hours before. Makes a big differance if you do.
 
funny story lol, 2 of my friends decided to take peptobismal before they rolled, and they took .2 molly , then another .1 later, and it totally killed their roll they didn't even roll at all lmfao,my friend got sum stupid idea that peptobismal slows your roll down right 8)=D lmfao
 
losthippy said:
I always chew and drop pills on an empty stomach so I imagine my stomach acid would be fairly strong
Click to expand...

Eating stimulates acid production, so an empty stomach will be less acidic (as homey implied a few posts up).

Top_Cat said:
I think what you're eluding to is Cimetidine, an H2-receptor antagonist [second generation antihistamine].

It inhibits the production of the P450 enzymes, which would result in high blood plasma concentrations of MDxx.
This can be dangerous as Cimetidine affects a whole load more drugs than just MDxx..
Click to expand...

I have heard specifically that mdma is absorbed better under basic (less acidic) conditions. There are many P450 enzymes, do you know if Cimetidine inhibits the main ones responsible for mdma metabolism?


TheDEA.org said:
Changing the pH (acidity) of your stomach might have some affect on how quickly the drug is absorbed, but I've played around with it quite a bit (adding both antacids and acids to the mix) and could never tell a difference.
Click to expand...

I'd be interested to hear if anyone has any anecdotal evidence either way, I also don't know any if it really makes a subjective difference.


alternativesurfer said:
It has to deal with your digestive system/how quickly your kidneys filter the drugs out of your system. This topic is dealt with on adderall forums allthe time but also applies to Mdma.
Just look up adderall potentiators on google. The reasoning behind the ph regarding adderall is the same with MDMA
Click to expand...

The stomach pH change has nothing to do with how quickly your kidneys filter drugs. There may be other potentiators that work in this way though.


misterpicky said:
So......... if you take either immodium or tums before you roll, it wont make much of a difference on how hard, or weak, you roll?

I have heard of someone on PR preloading on about 5000mg of vitamin c [crazy!] and consuming a pill. Said that it kicked in a lot sooner, and someone commented that it was because of his stomach being more acidic due to the vitamin c.

If that's true, then couldnt preloading on immodium or tums make it do something similar?
Click to expand...

Immodium as an mdma potentiator - what's the basis?

Haven't heard of vitamin c affecting strength of the roll before, though some people take it for its antioxidant properties (thus possibly reducing neurotoxicity). That said, I've read that vitamin c can inhibit histamine release (at high doses) so it may have an acid-reducing effect similar to H2-antagonists (though probably not specific to the gastric H2, so more side effects).
 
^
I realize the stomach acid has nothing to do with your kidneys. That's why I don't recommend any OTC acid reducers.
One needs to raise their body/urine ph.
Trust me, I deal with this crap all the time on adderall.
If I drink oj before, it takes 30mg for the drug to work (on my ADHD)
if I take a teaspoon of baking soda before, I get the same effect with 14mg.

The more acidic your stomach/body/urine is, the quicker you filter things out of your body.

The reason vit c isn't working for a lot of you is that most vit c supplements contain citric acid
 
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