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Very confused

ShAYZoN

ShAYZoN

Bluelighter
Joined
Oct 8, 2009
Messages
676
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G.T.L. My Life Is Bro!!
My friend against me advising here rolled off 5 bombs on Sunday then on Monday we went to a event where I live she took 2 bombs that day she didn't feel the roll of course so my friend was sellig very potent mushroom brownies she at a half didn't feel anything.

So she ate the other half like 30 mins later. Just a heads up these brownies where very good mushrooms and had 1.7g-1.9g in each of them... After 3 hours she still felt nothing. I'm curious to known if she didn't feel anything because mushrooms are a sertonin antagonist am I right?

So because she ate so many bombs didn't sleep much I'm wondering if she didn't feel it because there wasn't any sertonin left?? Also she has racing heartbeat,random headrush's she was seeing stuff on her walls moving btw this is morning and yesterday so 3-4 days later... Anyone ideas please should she ne worried I mean I know alot About drugs ecstasy and mushies especially sense I love those!!! Anyways ideas/help!

-ShayzoN
 
^^thats what I'm thinking. . . Is that why she didn't feel mushies? Also I'm curios to know why she is having visuals 3-4 days LATER I have HPPD I thin maybe she is going down the same path and getting I too.
 
ShAYZoN said:
^^thats what I'm thinking. . . Is that why she didn't feel mushies? Also I'm curios to know why she is having visuals 3-4 days LATER I have HPPD I thin maybe she is going down the same path and getting I too.
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I don't know if mushies are a serotonin agonist or antagonist. You could probably find that out.

They do act on some of the same receptors though. Serotonin from MDMA acts on all serotonin receptors whereas shrooms act on only a few and don't actually release serotonin, they just use the same receptor.

The likely reason for her weakened trip though was that MDMA dumps a lot of serotonin into the synapse (small space between the part of one neuron which releases a chemical and another neuron which absorbs it) which then acts on the serotonin receptors in the postsynaptic neuron. Such a large release causes the postsynaptic neurons to become less receptive to everything, not just serotonin. Since psilocin/psilocybin act on serotonin receptors (though only on some of them) , the effect of the trip is lessened until the receptors return to their normal state.

Rolling a lot makes it harder for them to return to this state, and they take longer to get there. That's why people who roll too much get depressed, because their natural levels of serotonin don't have as much of an effect.
 
Psilocin is a serotonin agonist (not all serotonin receptors, primarily the 5HT-2a set of receptors - 5HT is serotonin, 2a is a subset of serotonin receptors and the main set that psychedelics interact with). Your explanation makes sense to me - your friend had heavily depleted serotonin levels from overusing MDMA recently, which didn't leave enough left for the mushies. I can't guarantee that's what actually happened, of course, but if it was my friend asking me about it that's the explanation I'd offer. The other obvious consideration is if the brownies were no longer active, but I assume others had tried brownies from the same batch and found it to be fully active? I've never heard of using brownies as a mushroom carrier - wouldn't the heat from baking the brownies destroy the psilocin?

At any rate, assuming you are sure the brownies were active and not degraded at the time she ate one, and that she's shroomed before and they normally work for her, I'd say the serotonin depletion explanation sounds like the most plausible scenario.

Now, to play devil's advocate, I know some people like to do flips (combining psychedelics and MDMA) in the opposite of the traditional order, so they take the MDMA first and then the psychedelic as they're coming down. This would suggest that psychedelics should still be fairly potent even immediately after a roll. I'm not sure if psychedelics cause serotonin itself to be interpreted differently in the brain, or if they just happen to trigger the same receptors that are normally used for serotonin without changing how the brain responds to actual serotonin hitting those same receptors.
 
well first of all you have to test the pills/chemical that was taken to be sure what it actually was and percentage of mdma vs anything else was in it if any. Then you have a starting point for what is actually interfering with the psilcybin. find out what was in those bombs. pure mdma, molly? mabye some pipes? something the 2c series? There could be possible cross tolerance/.
 
bpayne: true, and it's worth checking out if possible, but I have a feeling if his friend ate *5* rolls that were some active drug other than MDMA, that would quite possibly be OD territory and she'd certainly know it wasn't MDMA. I can't imagine how anyone (at least anyone who's both rolled and tripped before) could mistake 2Cs for MDMA at any dose, and 5 times the targeted 'MDMA-like' dose of any 2C would be well into "tripping your balls off for at least the entire night" territory. Pipes at five times intended dose would probably be in OD territory and would, if anything, interfere less with mushies than MDMA would have. I can't think of anything that an experienced roller would mistake for MDMA, especially at that dose, that would have any known cross-tolerance with psilocin. Still, ya never know, and it's always good to keep in mind the possibility that pressed pills could be some entirely different drug from what they were 'supposed' to contain.
 
solistus said:
Psilocin is a serotonin agonist (not all serotonin receptors, primarily the 5HT-2a set of receptors - 5HT is serotonin, 2a is a subset of serotonin receptors and the main set that psychedelics interact with). Your explanation makes sense to me - your friend had heavily depleted serotonin levels from overusing MDMA recently, which didn't leave enough left for the mushies. I can't guarantee that's what actually happened, of course, but if it was my friend asking me about it that's the explanation I'd offer. The other obvious consideration is if the brownies were no longer active, but I assume others had tried brownies from the same batch and found it to be fully active? I've never heard of using brownies as a mushroom carrier - wouldn't the heat from baking the brownies destroy the psilocin?
Click to expand...

I see a lot of people here on BL talk about Psilocin when referring to the active component of mushrooms. I may be wrong here, and please correct me if I am, but most people who buy mushrooms get dried mushrooms.

It was my understanding that Psilocin being a very fragile compound, degraded when mushrooms are dried and that fully dried mushrooms contained very little, if any Psilocin. I thought that the main active in dried shrooms was Psilocybin.

I'm sorry, I don't mean to be splitting hairs here but I believe these are two similar, but still different compounds.
 
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Sorry, my bad. Psilocin is the active metabolite of Psilocybin and is therefore the source of the psychoactivity. Psilocybin is metabolized into Psilocin.

Dried mushrooms contain little to no Psilocin. Mostly Psilocybin, which is less fragile.
Both Psilocin and Psilocybin are present in the fresh mushrooms, making them more potent.
 
^^ To split hairs further, while it's true that psilocybin is converted to psilocin in vivo, it is only a theory that it is inactive and is only active after being converted. There is nothing to my knowledge that tells us for sure that it can't cross the blood brain barrier on its own as well. My experiences with other esters of 4-sub-tryptamines (4-AcO-DMT for example) leads me to believe that different peoples' body chemistries break down 4-AcO-Ts into 4-HO-Ts (or 4-PO-DMT which is psilocybin into 4-HO-DMT which is psilocin) at different rates, and that the acetoxy or what have you esters can also cross the BBB on their own and produce unique effects from their 4-HO counterparts. Some people find 4-AcO-DMT and 4-HO-DMT to be nearly indistinguishable, and I suspect that those peoples' bodies convert all or nearly all of the 4-AcO-DMT into 4-HO-DMT before it gets across the BBB. But others, like me, find the effects of the two to be very different indeed, two completely distinct drugs, and for those of us like me, I postulate that much less of the 4-AcO-DMT is converted to 4-HO-DMT before crossing the BBB, leading to unique effects.

I have never had a chance to sample pure 4-PO-DMT (psilocybin), so I can't test my theory as it extends to the example of psilocybin mushrooms.
 
I am not sure about this, but it could have just been from crosstolerance. Does MDMA have crosstolerance with most psychedelics?
 
I'm sorry you guy's i ment to say they where mushrooms dried in chocolate :) so yea.. My bad so they should of worked i ate one and was fucked up for like 6 hours they where defiantly legit.
 
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