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Lophophine

It's the last one on my list of 'essential things to try'. Basically MMDA without the alpha methyl group. From what i've read, low doses <250mg are similar to mescaline, but above that it takes on a character of it's own (probably more like MMDA which is weird, but in a good way)

My main question is surrounding whether it produces a feeling of sleepiness during the come up as with 150mg of MMDA I fell asleep between t+0:30 and t+1:00 (twice! only once did I manage to stay awake for the whole experience)
 
fastandbulbous said:
It's the last one on my list of 'essential things to try'. Basically MMDA without the alpha methyl group. From what i've read, low doses <250mg are similar to mescaline, but above that it takes on a character of it's own (probably more like MMDA which is weird, but in a good way)

My main question is surrounding whether it produces a feeling of sleepiness during the come up as with 150mg of MMDA I fell asleep between t+0:30 and t+1:00 (twice! only once did I manage to stay awake for the whole experience)
Click to expand...

Sorry to go OT, I wish I had something to add about lophophine but the gods have not yet delivered on that one.

F&B...MMDA is not at all sleepy when you get closer to 200mg. I took 190mg and it was stimulating....not very much but there was definitely no falling asleep. Personally from my one trial, I think the dosage for MMDA is 190-250mg for full effects.
 
I recently had access to Lophophine, it was a brown liquid which smelled like ammonia. Made it into a HCl salt and had some volunteers consume it orally, starting at 5mg, over a period of a few weeks. No one ever reported any positive effects whatsoever, apart from maybe a mild placebo effect. Approaching 120~150mg headaches were reported, and were intense and frequent enough that no one dared test higher than 150mg. At that point we stopped our testing out of fear of inflicting major damage.

In case anyone asks, yes, our NMR indicated is really was Lophophine.

So at least from my tests, Lophophine's a dud, and possibly dangerous.
 
I stumbled upon this and thought it may be of some value...

Anhalonidine (9) appears to produce a heavy-headedness and sedation similar to that of pellotine, but is about one fourth as potent, Dosages of between 100 and 250 mg produced a marked sedation, but again without any reported sensory changes, Lophophorine (10) in animal studies is the most toxic of the components of peyote, and in man an oral dose of 20 mg provoked vasodilation, an immediate headache, and a warm flushed feeling (Heffter, 1898). A 50-mg dose produced a marked slowing of the heart with a compensatory rise in blood pressure, but no suggestion of mescaline-like effects (Dixon, 1899), Anhalonine (11) has been evaluated in a single experiment with an oral dose of 100 mg and this led to an uneventful tiredness without any observed central effects of a sensory nature (Heffter, 1898).

From http://www.erowid.org/archive/rhodium/chemistry/shulgin.pea.sar.hop.html

I guess that answers my Q bout lophophorine and other tetrahydroquinoline cacti alkaloids. Wonder if this has anything to do with the headaches yer people experienced even tho u took lophophine. Perhaps there were impurities?
 
BTW.. MMDA is listed as 5-MEO-3,4-MDO in most databases but in PIHKAL it's 3-MEO-4,5-MDO. Which one is it and does anyone know the differences in FX???
 
(zonk) said:
Wonder if this has anything to do with the headaches yer people experienced even tho u took lophophine. Perhaps there were impurities?
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Interesting. That certainly would correspond with our results. Our NMR indicated our Lophophine was very pure after crystallization, we didn't perform additional analysis as our conclusion was this compound was not worth risking further in vivo testing.
 
morninggloryseed said:
Sorry to go OT, I wish I had something to add about lophophine but the gods have not yet delivered on that one.

F&B...MMDA is not at all sleepy when you get closer to 200mg. I took 190mg and it was stimulating....not very much but there was definitely no falling asleep. Personally from my one trial, I think the dosage for MMDA is 190-250mg for full effects.
Click to expand...

MMDA shouldn't be very stimulating. unlike it's cousins MDMA and MDA, it doesn't release DAT or NAT. it only releases serotonin and activates 5-HT receptors. i've used MMDA and lophophine, and can say they have some similar effects such as realistic visualizations similar to day dreaming but much more real feeling.

lophophine is similar to mescaline, but has more empathogen like qualites and produces little nausea in comparison. it is like a cross between MMDA and mescaline with general effects leaning more toward mescaline.

i heard it can be found in small amounts in peyote, but idk.
 
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