I have been using research chemicals for two years now. I have used more than a dozen RC's, and mixed some of them with LSD, MDMA, and ketamine.
Overall, I feel great. Psychedelics have provided me with expereinces that have inspired such mystery and amazement and awe within me. Everything is a complex infinite mystery forever trying to get to know itself, and we're all just little tiny helpless molecules of conciousness in the ocean of everything.
I also notice trails on things randomly when I am totally sober. This seems to happen totally randomly, and only to fast moving things that i'm not directly focusing on. It's not very often, just sometimes I'll see a trail here or there. I also notice my floaters a lot more.
I have noticed no depression or anxiety that can't be attributed to the many stresses of life. There is one exception to that however. It was after an LSD-methylone experience. My friend and I did methylone one night, and redosed several times. After two redoses, we decided that 1.5 hits of acid would be fun. WRONG. Intensely shitty weird dysphoric trip with a shitty feeling lasting several weeks, not very much motivation, bad mood, lows seemed extra low, my ups weren't quite so high.
It went away though. I blame the huge methylone dose massively potentiating the LSD, and just generally wreaking havoc with my brains. Not fun. Typical side effects of MDxx abuse though.
I am MUCH MUCH MUCH more weary of drugs like methylone and mephedrone and mdai and 5-iai and all those "feel good mdma replacements" compared to psychedelics. Psychedelics have their own risks, but....just look at mephedrone, that shit is sketchy as fuck.