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N&PD Moderators: Skorpio
dimenhydranate
- Thread starter bob123
- Start date
do you mean that if they take it it creates some sort of barrier around them that is impenetrable by liquids? That would mean that not only can it be used for sea-sickness but it could come in handy in case of falling overboard, well... for females that is.
This is a fascinating concept, thank you for starting this groundbreaking thread!
adder
Bluelighter
- Joined
- Mar 28, 2006
- Messages
- 2,851
It's dimenhydrinate and I think OP means a woman's vagina doesn't "get wet" so sexual intercourse is impossible without lubricants. Well, it's an anticholinergic and it acts similarly to atropine or scopolamine. You know that after taking non-lethal doses that make you fucked up you get dry mucosa (and a lot of different side effects aside from being very open and seeing things that are not there).As a general response to the OP, the answer is no, it's not true. At least not as long as we're talking therapeutic doses and not some silly attempt at tripping on high doses (>500 mg) of dimenhydrinate or diphenhydramine.
I've used Dramamine (dimenhydrinate) occasionally to overcome nausea associated with opiates, and I've used diphenhydramine quite extensively as a sleeping aid. Dimenhydrinate is the chlorotheophylline salt of diphenhydramine, and it is diphenhydramine which is responsible for its antihistaminergic and anticholinergic effects. I've never noticed any dryness or reduced vaginal lubrication as side effects of these drugs. However, I have noticed that I sometimes have dry eyes in the morning after taking diphenhydramine, especially if I've exceeded 50 mg. I presume it's due to antagonism of muscarinic acetylcholine receptors.
At very high doses, I'm sure dimenhydrinate can cause vaginal dryness, along with a whole range of other anticholinergic and antihistaminergic side effects. The antihistamines are not recreational in my opinion, and trying to trip or somehow get high on massive overdoses of these drugs is stupid and dangerous.
I have experienced the effect that the OP is referring to when taking alimemazine or promethazine in therapeutic doses. These are phenothiazine-class antihistamines which are used as sleeping aids in some European countries. I believe that they have more pronounced anticholinergic activity. They're quite horrible drugs really, and I'll never touch them again.
adder
Bluelighter
- Joined
- Mar 28, 2006
- Messages
- 2,851
Dimenhydrinate is just a 8-chlorotheophylline salt of diphenhydramine and it's converted to diphenhydramine in the body (therapeutic dose for dimenhydrinate is 50mg for motion sickness). It's no difference. Diphenhydramine is a first generation antihistamine (some antipsychotics are also in this class). Not commenting on what they're for, I'll just comment on that as they penetrate CNS they can produce side effects even at therapeutic doses but side effects are side effects (like 1% of population will get them) so let's leave them out. It's some myth I've never heard of before.
Drugs like dimenhydrinate or diphenhydramine also have anticholergic effects acting on mAch receptors. I don't think it's a very good idea to take dimenhydrinate/diphenhydramine for nausea associated with opioid use. As they produce effects similar to tropane alkaloids when used recreationally, they boost opioids effects. I used to smoke 200-250mg of Atropa belladonna leaves with after shooting morphine, that got me nodding like nothing else (mixing morphine with scopolamine on purpose to induce twilight sleep and make a person forget about pain must give similar effects).
Well Sir, I beg to differ. When used in therapeutic doses, 25-50 mg, they're actually quite brilliant for this purpose. In this dosage range, anticholinergic side effects are not usually noticeable. There may be a slight potentiation effect on opioid sedation, but not so much as to make it dangerous in my opinion.
Using potent anticholinergics or very high doses of antihistamines to boost the effects with opioids is an entirely different matter.
