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has anyone died from using E

Visionary_Kpsycho

Visionary_Kpsycho

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Now I know what you guys are thinking. This guy is fuking dumb. :!

But seriously, I heard that if you never tried it, and you don’t have the certain enzyme to digest it, you can die from it. Is this true? Also I heard if you have a restless heart (not considered heart disease or anything) MDMA, or E can kill you from only 1 or 2 hits

I have tried E, so I know that I dont have this enzyme thing. But what about the heart part?

And I am not talking about people dying from over heating, or over drinking. Just simply chillin out and relaxing, and then something wrong happens
 
Lots of people have died while using mdma. Mostly because they went crazy drinking to much water.

Some because they took way to much.

Some because they used it in combination with anti depressants.

And numerous other reasons.

Many many people have died by taking a pill and not knowing what was in it and it turned out to not be what they thought it was. Usually PMA.

Regards the enzyme idea..............never heard that one before.

A restless heart?? I have no idea what that is BUT mdma is probably not a good idea for anyone who is not in excellent physical condition.
 
If you have an enzyme deficiency you certainly run the risk over overdosing at a much lower rate because your body lacks the ability to break down the drug properly. One way to determine if you are enzyme deficient or not is to take a very small dose of a substance and test how long it stays in your system, if you take mdma for example, and you still feel strong drug induced effects the next morning when you wake up there is a good possibility that you are enzyme deficient.

If you are new to a drug its always best to start low and see how the drug effects you personally. Reading all the ancedotal information in the world isn't going to ever give you a clear picture of how the drug is going to effect you personally.

If you suffer from heart related illnesses or disorders its never a good idea to ingest any sort of stimulant. Stimulants can (and will) raise your heart rate, and depending on your particular condition, and if you are doing any additional activities (such as dancing) its very possible that your heart rate could be raised to dangerous levels.
 
If your question is, has anyone died after taking a nominal amount of MDMA on it's own, with no pre-existing medical conditions, excluding those who died through their 'behaviour', then I think the answer is probably no....
 
^ Well I would amend that to: under those conditions it's extremely rare for someone to die as a direct consequence of the drug interaction with the body.
 
there's a huge difference between MDMA and Ecstasy...
Some people are, yes, not compatible with MDMA and can't take it.

About heart troubles, MDMA is NOT the culprit. It's other shit in ecstasy pills, like random amps/meth/caffeine that gets your heart rate going sometimes and has the potential to cause troubles
 
MazDan said:
A restless heart?? I have no idea what that is BUT mdma is probably not a good idea for anyone who is not in excellent physical condition.
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Lol wut? Youve seen my pictures and Im no Mr Universe in fact when I used MDxx most frequently I was a bit heavier than I am now..............I never had a problem.......I also had high blood pressure for awhile and still never had a problem....................how about using a different word than excellent
 
purplefirefly said:
If you have an enzyme deficiency you certainly run the risk over overdosing at a much lower rate because your body lacks the ability to break down the drug properly. One way to determine if you are enzyme deficient or not is to take a very small dose of a substance and test how long it stays in your system, if you take mdma for example, and you still feel strong drug induced effects the next morning when you wake up there is a good possibility that you are enzyme deficient.
Click to expand...

Is this hypothetical or established? I'm not aware that being deficient in one of the enzymes that metabolises MDMA can make a significant difference. My understanding is that CYP2D6 and CYP3A4 are responsible; CYP3A4 has very little variability in vivo from one person to another and I don't think CYP2D6 deficiency alters the subjective experience. I've read a bit about it and it's suggested that it may affect neurotoxicity, but that isn't the mechanism for acute complications anyway. Also I'm CYP2D6 deficient myself, which is very noticable with some other substances (i.e. DXM) but not at all with MDMA :)


I just looked this up and see that COMT is also involved. Not sure about the existence or effects of it's variability.
 
Yes people die from MDMA. I haven't heard of the enzyme thing before, sounds interesting.
As for heart problems and MDMA I have a mate with a heart problem and he takes MDMA but he is much more careful about it because he says he has a higher chance of having a heart attack.
So he times himself, every half an hour of dancing he will take a ten minute rest kinda thing. Works for him
 
from MAPS lit review:

It has been hypothesized that genetic variations in CYP2D6 activity may influence risk of MDMA toxicity. CY2D6 activity is genetically determined and up to 10% of the Caucasian population has deficient CYP2D6 activity. It has therefore been suggested that individuals having this autosomal recessive trait may have increased plasma drug concentrations and increased risk of acute adverse response to MDMA. The fact that CYP2D6 is apparently easily saturated makes this possible source of individual sensitivity appear less significant. In fact, there currently seems to be no evidence that the poor metabolizer genotype is by itself a major risk factor for acute MDMA toxicity. Schwab et al. (1999) found that three illicit MDMA users who developed MDMA-related hepatotoxicity all had extensive CYP2D6 activity. In addition, Kreth et al. (2000) reported that the poor metabolizer trait did not lead to significant alteration in maximal drug plasma concentrations in an individual participating in a clinical study of the MDMA analogue, MDE. Formation of the major demethylenated metabolite (analogue to HMMA) was approximately 44% that of other volunteers, however. This provides further evidence that the role of CYP2D6 in MDMA metabolism is sufficiently limited that it is not a major risk factor in healthy individuals in a clinical setting.
 
coopie said:
http://en.wikipedia.org/wiki/Anna_Wood_(schoolgirl)

technically 'water toxification' - but I'll never forget being scared shitless as an aussie 13 year old hearing this storey - but the fear didn't last, put it that way
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From that Wiki:

"Her death was initially considered to be the result of a contaminated tablet; it was later determined that she had died from the effects of water intoxication secondary to use of MDMA (ecstasy)"

"The raised awareness of ecstasy-use led to the Australian state governments instituting new laws in the running of dance venues. In NSW, the Code of Practice for Dance Parties was passed in 1997, which made the provision of chill rooms and free water compulsory for clubs to obtain their licence."

...Do they not realize that she died from drinking too much water? Forcing clubs to give out unlimited free water seems completely ass backwards.
 
^ I get what you're saying, but it's better than having people refuse to pay ridiculous prices for a bottle of water and having the opposite happen (dehydration), which I guess is probably more common than water intoxication.

The pros outweigh the cons by far, IMO.
 
^ Agreed. But I think it'd be far more beneficial to actually TEACH people about the dangers of water intoxication. When I started taking E people kept telling me to make sure I drink a lot and one of the large dangers was dehydration. I learned through my own research that drinking too much water was a danger as well. A lot of the kids out there even today have no clue and will drown themselves thinking that the E alone with dehydrate them, when it's mostly the dancing.

Easy rule of thumb: drink when you're thirsty. That's it.
 
I used to be completely un-educated when I started doing E (around 5 years ago), and I used to drink MASSIVE amounts of water while on MDMA. Looking back at those days I'm happy and surprised that I didn't die. Research saves lives.
 
WorldWarMe said:
I used to be completely un-educated when I started doing E (around 5 years ago), and I used to drink MASSIVE amounts of water while on MDMA. Looking back at those days I'm happy and surprised that I didn't die. Research saves lives.
Click to expand...

True, true true true. The more you know about e (or whatever you're taking) the safer you are. We're not doctors but there is a wealth of this information on this board and on Erowid and other places that will keep you safe.
 
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