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Amphetamines with Hydrochlorothiazide (BP med) for potentiation?

Cloud_9

Cloud_9

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So I was given Hydrochlorothiazide (Esidrix) as a second line medication to help treat a genetic fact that in my family no matter how sporting and athletic you are; your blood pressure magically jumps to 170/100 the second you become an "adult". For me this was when I turned 19 and went into the clinic for a physical and had the nurses check 3-4 times with the machine, and consequently think it broken, manually checked another 2-3 times only to indeed find out my average completely resting BP was hovering around 180/110; and this was on methadone, before I started using stimulants. A quick referral to an endocrinologist to make sure I had no adrenal diseases led me to be treated with this medication. Unfortunately, once i started using d-amphetamine (4 x 15mg Dexedrine/day) along with copious amounts of caffeine the medication due to its diuretic nature had me so dehydrated the benefits of the sodium excretion where not worth the increase strain on my heart pumping virtual sludge along my circulatory system.

Consequently I asked the pharmacist at CVS about possible interactions and she said it could potentiate amphetamines and agreed that the diuretic nature could dehydrate me along with caffeine and amphetamine preparations. I called my doctor and he switched me over to another medication after calling up the pharmacist at his hospital and getting an "Looks OK to me" back to which I brought in a printout from CVS stating the possible interactions next visit. The balls on some of those "know it all" pharmacists...

My question is: How could this medication potentiate stimulants and specifically amphetamines and would it be too risky or not worthwhile to take it along with my current calcium-channel blocker medication? If it is indeed something that would help, should I stop the calcium-channel blocker?

But those who want medical verification by some source as to the potentiation:

"Alkalinizing Agents: Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentiate the actions of amphetamines."

As taken from: http://www.rxlist.com/dexedrine-drug.htm#ad which has full manufacturer's brochers that come with typical 100 count pre-sealed bottles.

To get an idea of how frustrated I am with tolerance I have been on d-amphetamine for like 1 1/2 years now and other stimulants off and on for a long while before; I have a habit of downing handfuls of "Tums" (calcium carbonate) to make my stomach and blood Ph lower as well as taking 3 x 200mg tablets of magnesium a day as well as trying to get in a minor DXM use on the weekend when I am not busy augmented by Ketamine use when I can get it. So you can see I'm not a foreigner to potentiating amphetamines, but I am pretty much out of other options as far as I can see... any other ideas are gladly welcome too of course :D
 
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I cant think of why this might be dangerous offhand, but I know that you're not supposed to mix propranolol (a beta blocker) with stimulants cuz it causes an unsafe rise in blood pressure (paradoxically). So I'm guessing this "potentiation" might be along the same dangerous lines. Really I wouldnt be overeager to try this, maybe you should cockblock the calcium channel blocker.
 
pallidamors said:
I cant think of why this might be dangerous offhand, but I know that you're not supposed to mix propranolol (a beta blocker) with stimulants cuz it causes an unsafe rise in blood pressure (paradoxically). So I'm guessing this "potentiation" might be along the same dangerous lines. Really I wouldnt be overeager to try this, maybe you should cockblock the calcium channel blocker.
Click to expand...

In before I could edit in the medical literature that actually says why, but you are right; some beta blockers are absolutely deadly to mix and OD'ing on them is near-impossible to recover from if you fuck it up. Had a cousin who actually took his father's beta-blocker in a Xanax black-out and thank god they found him within like 10m of him taking it because once in the ER, having his stomach pumped, charcoaled to death, and then put on a ventilator; the doctor said he pretty much could have died instantly from heart failure and they couldn't do much of anything to bring him back and he was so fucking lucky to have his stomach pumped before it was absorbed fully and all that. In any event the tox-screen return was lolers positive for like everything possible, think he was trying to go out in a dase of glory.... vOv

But those who want medical verification by some source as to the potentiation:

"Alkalinizing Agents: Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentiate the actions of amphetamines."

As taken from: http://www.rxlist.com/dexedrine-drug.htm#ad which has full manufacturer's brochers that come with typical 100 count pre-sealed bottles.
 
Since nobody in OD seems to have any idea about this, could I request that moderator/admin go ahead and send it over to ADD; I knew it was a borderline ADD thread, but felt there are enough smart people in OD that I would get a bite, apparently I'm just not juicy enough. ;)
 
miconorphine said:
here are some studies on propranolol potentiations of amphetamine

http://bluelight.ru/vb/showthread.php?t=480787 are you sure it's dangerous to mix propranolol with amphetamines?
Click to expand...

I'm not talking about a beta-blocker here if you even bothered to read the thread title. Maybe you are referring to the above comment about my concerns of with overdosing with beta-blockers; but maybe you could quote what you have an issue with or what you can add to.

_________

To any other people who could help; I would very much appreciate at least a guess at what possible interactions could have led to statements on the manufacturer's information for prescribes.

It said that Hydrochlorothiazide can potentiate Amphetamine when used together and to take caution to start at a lower dose than normal when being treated with both. I am trying to find out by which mechanism or action this combination could produce a synergistic effect as the information says in the first link in the OP.
 
Cloud_9 said:
I'm not talking about a beta-blocker here if you even bothered to read the thread title. Maybe you are referring to the above comment about my concerns of with overdosing with beta-blockers; but maybe you could quote what you have an issue with or what you can add to.

_________

To any other people who could help; I would very much appreciate at least a guess at what possible interactions could have led to statements on the manufacturer's information for prescribes.

It said that Hydrochlorothiazide can potentiate Amphetamine when used together and to take caution to start at a lower dose than normal when being treated with both. I am trying to find out by which mechanism or action this combination could produce a synergistic effect as the information says in the first link in the OP.
Click to expand...

prick
 
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