stirfry
Bluelighter
- Joined
- Aug 12, 2006
- Messages
- 1,448
well i just crushed up a concerta(alza 27, alot of work)and some seroquel 400 and mixed the two to fine powder very fine powder haha and wondering what my effects are going to be? i know some people think its stupid to snort seroquel but to me it hits me so much harder and it feels like a xanax to me i don't know why but it does im really sensitive to the medication. One 400 mg pill can last me 2 weeks and i would get high off it every day, and the methylphenidate hits me hard when i snort it so i think this is going to be a good high 8 ball kind of thing. any thoughts?
Personal opinion of quetiapine (seroquel) aside, this is a pointless combination from a pharmacological standpoint.
Methylphenidate (concerta) exerts it's psychoactive effect by inhibiting the reuptake of dopamine (and norepinephrine) out of the synaptic cleft (the area where neurotransmitters activate chemical receptors). This results in abnormally high amounts of dopamine and norepinephrine activating their respective receptors. The increased action of dopamine is thought to be primarily responsible for the sought after effects (including euphoria), while the increased action of norepinephrine is believed to cause unwanted side effects (jitteryness, fast heartrate etc.).
Quetiapine belongs to a class of drugs called neuroleptics, or anti-psychotics. These drugs act primarily as 'dopamine antagonists' (quetiapine has other actions as well, but I won't go into that now). what that means is the drug binds to dopamine receptors in the synapse, but does not activate them. If a quetiapine molecule is already bound to a dopamine receptor, dopamine itself cannot bind and stimulate that receptor. Thus, the affect of dopamine is essentially blocked by this type of drug.
Therefore, quetiapine will work against the desirable effects of methylphenidate, and vice versa.

