Why aren't we using these yet?

[/navarone/]

I don't understand why a 5-HT1A full agonist hasn't been brought to the market yet.

Because they desensitize very quickly.
Also:

Activation of 5-HT1A receptors has been demonstrated to impair cognition, learning, and memory by inhibiting the release of glutamate and acetylcholine in various areas of the brain. Conversely, 5-HT1A receptor antagonists such as lecozotan have been shown to facilitate certain types of learning and memory in rodents, and as a result, are being developed as novel treatments for Alzheimer's disease. Wiki.

So regular agonists would be safer IMO.

If you haven't already, have a look on the pros and cons of 5-HT1a agonism
http://en.wikipedia.org/wiki/5-HT1A_receptor

 

[kken]

hats off for you. free and easy flow of information is critical for good scientific progress

 

[Hodor]

I have a friend who is a pharmacist, who was addicted to Survector (funny name, like Terminator). He developped a giant form of acne. Anyway, as Wiki says, it's not very difficult to withdraw from.

Survector has to be just about the most badass name for a drug ever.

It kind of sounds like a name for one of those oversized Rambo-style "survival" knives with a compass in the pommel, or a straight-to-TV SciFi channel action movie starring Dean Cain as the lone survivor of a plane crash in the jungle, trying to escape a manic coke baron and his genetically enhanced cybernetic jaguars.

 

[Hodor]

As for Tianeptine... in my experience, its a great antidepressant, even though the body quickly desensitizes to it.

When you're suffering from severe seasonal affective disorder like I do and you feel the winter blues suddenly kicking in, you want your AD to start working instantly (to quote Myron from Fallout 2: "What timeframe are we looking at?"-"Yesterday."), and being told that you have to give it two or three weeks to take full effect feels like an extended middle finger. Tianeptine provides almost instant relief, and by the time it stops working, christmas is around, and your mood starts improving by itself as you get more daylight hours.

So yes, tianeptine might not be a long-term solution, but for sudden depressive episodes and/or SAD, it is a godsend and fills a niche that has been largely ignored by the pharm companies so far.

 

[cerealbowl]

Something that most psychiatrist underestimate is the psychological aspect that may influence they disorder, i mean c'mon how many psychiatrist analyse and advice you on how to deal with your daily routines, your social life before prescribing antidepressants or else?

They are just like hey u feel that and that (why i don't care) just take theese and you be fine, and sometimes they end up prescribing you with massive ammounts of SSRIs, SNRIs, benzos, maybe come opioids and you'll be fine (and many dont care about long term side effects), while in my opinion as a psychotherapist they should be able to investigate what asoects of your life may cause theese symptoms and prescribe you with helthy routines and advices along with some medications of course to HELP but not to CURE.

I'm disgusted by many psychiatrist that seems to have they're fixed schedule of pharms depending on what the patient might experience.

I'm a person that firmly believe that medications are worthless unles psychological/enviromental conditions of the patient are taken for granted.
Also after they take they degree/master whatever, they don't tend to investigate on further innovations in the pharmacological market, recent studies about depression and what not. A psychiatrist should research and study novel therapies even after their big WOLALA degree.

I've heard of psychiatrist prescribing dexedrine and methylphenidate plus valium to 8 year old kids!! Jesus fucking christ! Do they minimally care about the long term effects of theese therapies?

I hope u get my point.

There's a huge difference between a psychiatrist and a psychologist. Psychiatry is very much concerned with the realm of psycho-pharmacology and could give less of a fuck about actual psychological analysis, etc. That's the sad truth. Psychotherapy is slowly but surely making way for the more "clinically efficacious" world of psycho-pharmacology. It's a quick, band-aid fix that pharmaceutical companies make tons of money on, why wouldn't it slither its way into the foreground?

It's a sad world we live in when companies are trying to export anti-depressants to Asian cultures who accept sadness and depression as part of the human psyche and a necessary part of life. At that point we're not exporting drugs, we're exporting ideals and beliefs... and that's pretty subversive and evil.

 

[Vaya]

And they consider euphoria to be an unwanted, undesirable side effect. Am I right?

I am pretty sure I have read this in those goofy information packets you get with your prescription, back when I was actually taking antidepressants. I cant remember specifically which one, maybe two, compounds that listed euphoria as a negative side effect, but I remember laughing about it

~ vaya

 

[debaser]

There's a huge difference between a psychiatrist and a psychologist.

You're totally right. That's why I see both every week. It should be mandatory to see a psychologist when you see a psychatrist, or have a real psychotherapy with your psychiatrist along with prescribed meds.

 

[Dysphoric]

I've heard of psychiatrist prescribing dexedrine and methylphenidate plus valium to 8 year old kids!! Jesus fucking christ! Do they minimally care about the long term effects of theese therapies?

I hope u get my point.

Buonasera Signori

This makes me want to kill hearing this. The parents especially. Those kids are going to be social misfits when they get older, not to mention all the problems they will have with everything.