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Why aren't we using these yet?

Dysphoric

Dysphoric

Bluelighter
Joined
Feb 3, 2010
Messages
392
So, lately I've been wondering why we haven't been able to see any effective anti-deppressant options, here in the U.S.

Such as the new (SSRE) Tianeptine or SSRA's like (MMAI). I haven't looked into MMAI to much, but from what I've read it seems pretty good. If they say it's as effective as it is, and is said to be Non-Neurotoxic why aren't we using something so useful like it? Yet, we have shit like SSRI's floating around. I don't get it!

I've wanted to try Tianeptine for sometime now, but you can't get it here in the U.S. why the hell not!?

I do think MMAI would be an amazing option thoe apparently it's got strong empathogenic effects, and can induce euphoria while keeping a non-toxic status.

Thoughts?
 
Tianeptine is an old drug here in Europe. But amphetamine-like tricyclics are a big no no nowadays.
 
Ive been using MDAI as an antidepressant for a week with good results, took 60mg twice a day.

I'm resuming it once i'm back on memantine (ran out).
 
I always mix up amineptine with tianeptine. But according to wiki tianeptine is also a tricyclic.
Click to expand...

How is amineptine? how is it compared to other stimulants like amphetamine? just curious
 
We don't see a lot of novel new antidepressants because very few compounds any company has made in the past 20 years aside from SSRIs/SNRIs actually show clinical efficacy to the standard set by the FDA.

No company is interested in these research chemical compounds because they don't have the patents for them. Tianeptine's main effect is difficult to reproduce and the holding company also owns the rights to all similar compounds.
 
SSRAs have the same neurogenesis effect than SSRI's but it starts to take affect after like 2-3 days instead of 2-3 weeks with ssris. The empathogenic / slight euphoria elevates your mood instantly while waiting for this long term effect to take effect. Sounds good to me.

Usually doctors have to Rx benzo when starting with SSRI to provide instant relief and to make sure patient doesnt feel the ssri's starting anxiogenic effect. With SSRA's this woudn't be needed

Then again safety and long term impact (read: harm) haven't been studied. Its very hard for SSRAs not to initiate cascade effect in NE/dopamine and possibly substance p release. Is this a bad thing? who knows
 
yaesutom said:
How is amineptine? how is it compared to other stimulants like amphetamine? just curious
Click to expand...

From Wiki (yes I'm lazy this is Sunday):

Introduced in France in 1978 by the pharmaceutical giant Servier[4] and marketed under the trade name Survector, amineptine soon gained a reputation for abuse due to its short-lived, but pleasant, stimulant effect experienced by some patients. (This is to be distinguished from its antidepressant effect, which appears in approximately 7 days after commencing treatment.) This led to the Food and Drug Administration suspending the marketing authorisation for Survector in 1999 and France withdrew it from the market, however several developing countries continued to produce it up until 2005.
Click to expand...

I have a friend who is a pharmacist, who was addicted to Survector (funny name, like Terminator). He developped a giant form of acne. Anyway, as Wiki says, it's not very difficult to withdraw from.
 
Captain.Heroin said:
And they consider euphoria to be an unwanted, undesirable side effect. Am I right?
Click to expand...

No, not really. Abuse potential can be a negative thing but not the end all for a drug. I think the problem is generally that those with severe depression still don't respond exceptionally well to these drugs, or that there is a response but it's no prolonged.
 
I guess that as in terms of antidepressants the pharmaceutical companies should aim towards effective non abusable anxiolitics and drugs that promote emotional and emphatic effects (not try like MDMA or psychedelics) without aiming at euphoric side effects that can lead to addiction and underestimation of drug-unconditioned emotions (reward system basically) like observed in severely adicted methamphetamine users that are unable to exprience pleasure due to the exagerate rush of neurotransmitters making common emotions seem null or un unsatistfying (apart from the neurotoxic damage they cause to their dopamine reward system).

Something that most psychiatrist underestimate is the psychological aspect that may influence they disorder, i mean c'mon how many psychiatrist analyse and advice you on how to deal with your daily routines, your social life before prescribing antidepressants or else?

They are just like hey u feel that and that (why i don't care) just take theese and you be fine, and sometimes they end up prescribing you with massive ammounts of SSRIs, SNRIs, benzos, maybe come opioids and you'll be fine (and many dont care about long term side effects), while in my opinion as a psychotherapist they should be able to investigate what asoects of your life may cause theese symptoms and prescribe you with helthy routines and advices along with some medications of course to HELP but not to CURE.

I'm disgusted by many psychiatrist that seems to have they're fixed schedule of pharms depending on what the patient might experience.

I'm a person that firmly believe that medications are worthless unles psychological/enviromental conditions of the patient are taken for granted.
Also after they take they degree/master whatever, they don't tend to investigate on further innovations in the pharmacological market, recent studies about depression and what not. A psychiatrist should research and study novel therapies even after their big WOLALA degree.

I've heard of psychiatrist prescribing dexedrine and methylphenidate plus valium to 8 year old kids!! Jesus fucking christ! Do they minimally care about the long term effects of theese therapies?

I hope u get my point.

Buonasera Signori
 
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