N&PD Moderators: Skorpio
2,5-dimethoxy-4-isopropyl PEA?
This might not warrant its own thread, but I was wondering why this wasn't in PiHKAL, or anywhere else for that matter. Given that methyl, ethyl and propyl groups at the 4-position are all active I can't think of any reason this wouldn't be.
Anybody got any info on this?
planckunit
Bluelighter
1) a lot harder to make
2) presumably not active (i thought DOiP was not active, but don't quote me on this)
there's been a thread on this before
dread
Bluelighter
The allyl would be a lot more interesting, IMO.
tryp2fun
Bluelighter
In Pihkal, Shulgin found that DOIP was down about 10-fold in activity compared to DOPR (you have to read the section on DOPR), so he never made 2C-IP, probably assuming that it would also be low activity. However, it seems that you can't necessarily extrapolate from the DOX series to the 2C-X series, so 2C-IP may well be active. However, it is not as easy to synthesize as the others in the series, so that may be why it has not been made and tested.
I agree that allyl (2C-AL) would be interesting and most probably highly active.
dread
Bluelighter
... but I'd be even more interested in 2c-cn. The synth is relatively easy, if you can acquire the 2c-b needed for the synth...
In case someone doesn't know, 2c-cn is 4-cyano-2,5-dimethoxy-pea. Shulgin briefly mentions it in pihkal, but never assayed it afaik.
egor
Bluelighter
I have no doubt that 2c-iP will be active, but in the 100's of mgs range if the potency drop in DOIP corresponds to it's 2c counterpart. Potency has no relation to the quality of the experience...
tryp2fun
Bluelighter
I don't believe that you can predict the activity of 2C-IP from the activity of DOIP. In the DOX series, there is no significant change in activity in the DOM, DOET, DOPR series (all active at ca. 5 mg), followed by a drop in DOBU, while in the 2C series, there is a significant increase in activity from 2C-D (> 50 mg) to 2C-E (ca. 20 mg) to 2C-P (ca. 10 mg). If you were to extrapolate from the DOX data, you would not expect any change in the 2C series. Also, the halogenated DOXs (DOC, DOB, and DOI) are more active than DOM and DOET, while 2C-B and 2C-I are less active than 2C-E and 2C-P. The presence of the alpha-methyl group in the DOXs seems to exert a steric effect on the 4-substituent. My prediction is that 2C-IP would be similar to 2C-E in activity.
hamhurricane
Bluelighter
don't forget about 2C-T-4 (8-20mg) which is generally considered to of equal (or greater) potency than 2C-T-7 (10-30mg) so the isopropyl group does not necessarily mean there will be a significant potency drop
EDIT: and just to round it off Aleph-4 (12-20mg) is about 1/3rd the potency of Aleph-7 (4-7mg) im aware these are not directly comparable but just some food for thought
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dread
Bluelighter
On the other hand alkyls and thioalkyls are hardly directly comparable...
Work up starting paranoidly low. Start with like, 1mg, and confirm that you get no effects (if it is equipotent with 2C-P, you'll likely feel something, but it's probably weaker). Then work up, seperating each trial by days or a week, until you get to an active level.
I don't think there is any publicly available dosage information on this. I also question whether what you got is actually 2C-iP, and not some other 2C-X, since there don't seem to be any vendors selling it.
greenmeanies
Bluelighter
if you do indeed have 2c-ip i'm sure we all would love a detailed trip report of effects as you carefully work up in dosage.
personally i'm a little skeptical, probably 2c-i or 2c-p (or a combination of both!)
TheAzo , I'am 100 % sure that will be 2C-iP. 150 euro per gram .
I will take this from Europe laboratory . Any time ago I received massage :
Hi,
For you interest: at the moment we are working on a special new compound -
2,5-Dimethoxy-4-isopropylphenethylamine or 2C-Is.
This compound has not been synthesised before. However its analogs were
mentioned :
(1) 1-(2,5-Dimethoxy-4-isopropylphenyl)-2-aminopropane
(Reference:F. A. B. Aldous, B. C. Barrass, K. Brewster, D. A. Buxton, D.
M. Green, R. M. Pinder, P. Rich, M. Skeels,
and K. J. Tutt / Structure-Activity Relationships in Psychotomimetic
Phenylalkylamines // Journal of Medicinal Chemistry, 1974, Vol. I7, No.
10, pp 1100 – 1111)
2) 1-(2,5-Dimethoxy-4-isopropylphenyl)-2-aminobutane
(reference:Robert T. Standridge,* Henry G. Howell, Hugh A. Tilson, John H.
Chamberlain, Henry M. Holava, Jonas A. Gylys, Richard A. Partyka /
Phenylalkylamines with Potential Psychotherapeutic Utility. 2. Nuclear
Substituted 2-Amino-1-phenylbutanes, J. Med. Chem 1980, 23, 154-162).
The new compound supposedly possesses similar pharmacological properties
to 2 C-E.
We may proudly call this compound an exclusive product.
I order few times from him and always everything was ok.
They always include MSDS.
I took 2C-I and 2C-P , so I will recognice any of these substances.
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atara
Bluelighter
2ci will work just as well; iodides are always more reactive than bromides in nucleophilic substitution.
That sounds almost too easy ;-) Need to do more research, but it sounds like it would be almost trivial to prepare, though how pure it would be is another matter.
Unfortunately i'm fresh out of alkali cyanides, but there are ways to obtain those.
And yes, it 2C-CN looks like a fascinating compound for further elucidating the SAR for psychedelic phenethylamines. Though, i think it's likely to be in shulgin's book coming in the summer, since it's so obvious and so easy.
tryp2fun
Bluelighter
Alkali metal cyanides won't work. You need to use synthesis details removed to make a aromatic nitrile.
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any major dude
Bluelight Crew
My thoughts exactly. I really like alkylated 2c-x's, but prefer halogenated DOx's. Very strange as i'd have thought the alkylated DOx's would be more interesting. Good thread by the way, pretty interesting stuff. I'm always interested in new 2c-x's. I'd like to try some of the 2c-g series at some point, thought some are awfully long lived, and I've felt 2c-se is an often overlooked entry in PiHKAL. Definitely areas worth looking into
