2c-e-n

[ungelesene_bettlek]

if one would attach another amino group at the 4-ethyl group of 2C-E, one would get a quite symmetric molecule. I wonder if this would be active...

 

[tryp2fun]

if one would attach another amino group at the 4-ethyl group of 2C-E, one would get a quite symmetric molecule. I wonder if this would be active...

Doubtful, since the 4-substituent should be non-polar for good activity.

 

[LabRatNW]

Doubtful, since the 4-substituent should be non-polar for good activity.

What about 2c-c and 2c-b? Or the Methoxy analog? No-sir. I believe he may have an active compound.

 

[vecktor]

What about 2c-c and 2c-b? Or the Methoxy analog? No-sir. I believe he may have an active compound.

in general use nonpolar=hydrophobic

chloro bromo ethyl methoxy all hydrophobic.

\I can't see the compound being active especially with the hydrogen bonding. Additionally diamines are often potent HERG ligands. Tread very carefully. however 'Make em taste em' is the only sure way to know.

 

[tryp2fun]

in general use nonpolar=hydrophobic

chloro bromo ethyl methoxy all hydrophobic.

\I can't see the compound being active especially with the hydrogen bonding. Additionally diamines are often potent HERG ligands. Tread very carefully. however 'Make em taste em' is the only sure way to know.

I should have been more specific. The amines would be protonated at physiological pH, so there would be a plus charge on the side chain (good) and on the 4-substituent (bad). Even 2,4,5-trimethoxyphenethylamine is inactive, according to Pihkal, though that may be due to rapid metabolism by MAO.

 

[perpetualdawn]

bump