I dont agree that cathinone's are weak, for example I dont find mephedrone weak at all, but due to its healt issues i limit my use of that, i found methylone a potent drug too, yes they are more dopaminergic but they have their own place, i like to try differend compounds and i find the cathinones valuable options.
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N&PD Moderators: Skorpio
4-fluoromethcathinone
- Thread starter MeDieViL
- Start date
I personally wouldnt take that stuff, 4 bromoamphetamine is a very potent serotogenic neurotoxin (a compound no human should ever take), 4BMC can be just as bad. (I certainly hope this one isnt going to come available on the RC market).Last edited:well, i think I remember something about 4-br-methamphetamine not being very active which i dont believe. I dont remember where I read that but I dont think I high enough dose was assayed to come to a genuin conclusion. It should be more serotogenic than mephedrone. interesting thing is in PIHKAL 3,4-ethylenedioxy compounds where either inactive(which i dont believe), or less active than methoxy/methyledioxy counterparts. It's hard to really truly figure out how good/active these substitutions are gonna be. I'm positive 4-br-cathinone would be nice but who knows how the methcathinone will turn out. Especially since like i said before, with these cat/mcat analogs they dont always behave like thier amphetamine brothers and sisters
No, but there's data on the amphetamine counterpart parabromoamphetamine. It could be less toxic because of the ketone group but i wouldnt take it without some research behind it.
Is there any research on parabromomethamphetamine? My knowledge is too limited to know what a ketone and a extra methyl group can do, can you explain why you beleive they would be less toxic? (its because parabromoamphetamine is a highly potent serotogenic neurotoxin i'm worried).not much, but if i remember correctly(posted on previous page) it was inactive atleast at the levels tried. Not sure how much scientific info there is. 4-br-A was tried aswell, surprisingly. I dont remember if the dose of 4-br-MA vs the dose of 4-br-A was comparable to the dose of PMA vs PMMA. I think it was tho, so the active level of 4-br-MA would be much higher than expected(probly)fluoro isn't considered toxic cuz it only adds a weak serotogenic element vs. the dopaminergic side. It's all about serotogenic potency vs. dopamine. So like 4-Fluoro is the weakest, methoxy is next, then alkyls, then the halogens Cl, Iodine, then Br. Methylthio is alittle different, it's exceptionally dangeroust cuz the thio adds an MAOIa element to it), i would assume of all of them that one's the most toxic(by active dosages)
dread
Bluelighter
Because serotonin receptors don't like heavier halogens in the para-position. They go all "iewww, bromine!" and then they just shrivel up and die.
nuke
Bluelighter
- Joined
- Nov 7, 2004
- Messages
- 4,190
They do like halogens that are about as electronegative as carbon in the 4-position, the 5HT2 receptors anyway. Fluorine's electronegativity is closer to oxygen, so it's preferential for NET/DAT usually, while heavier halogens are more selective for SERT. Hence the preference for 4-Cl, 4-Br and 4-I amphetamine to be serotonergic neurotoxins.
Hmm, do you have a source for that? Besides PMA is less neurotoxic then MDMA (atleast pmma is) due to it also being a MAOI.
If your wrong and take such compounds alot of damage could be done
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Srry for my late reply, have been up with other things.
Is PMA only a MAOA inhibitor? I tought it also inhibited MAOB too.
Here's the paper on PMMA,
Evaluation of the neurotoxicity of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine, PMMA).
Steele TD, Katz JL, Ricaurte GA.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21224.
These studies assessed the neurotoxic potential of N-methyl-1-(4-methoxyphenyl)-2-aminopropane (para-methoxymethamphetamine; PMMA), an amphetamine analog that has surfaced in the illicit drug market. Repeated subcutaneous injections of PMMA caused lasting, dose-related reductions in regional brain concentrations of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA), and in the density of [3H]paroxetine-labelled 5-HT uptake sites. Comparison of the neurotoxic potential of PMMA to that of para-methoxyamphetamine (PMA) and 3,4-methyl-enedioxymethamphetamine (MDMA) showed that equivalent doses of PMMA and PMA (80 mg/kg) produced comparable depletions of 5-HT, but that these depletions were not as pronounced as those induced by a lower dose of MDMA (20 mg/kg). Striatal DA was not affected on a long-term basis by any of the ring-substituted amphetamines evaluated in this study. These data suggest that PMMA, like PMA and MDMA, produces long-term (possibly neurotoxic) effects on brain serotonin neurons, but that PMMA is less potent than MDMA as a 5-HT neurotoxin. Further, they raise concern over the illicit use of PMMA since humans could be more sensitive than rodents to the 5-HT neurotoxic effects of PMMA and related drugs.
