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MDPV - So how dangerous is it?

nuke said:
Amphetamine is a known toxin to dopaminergic neurons. There was a study by Ricaurte on primates that suggested that even ADHD doses of amphetamine could damage neurons.
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Looks like i'm long past fucked than. Damn pharmaceutical companies and their web of lies. If this proof gets more widespread I sense a massive lawsuit:!
 
Choronzon333 said:
Looks like i'm long past fucked than. Damn pharmaceutical companies and their web of lies. If this proof gets more widespread I sense a massive lawsuit:!
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Actually i'm glad amphetamine is marketed, what would be the alternative, reboxetine or other garbage?

By the way, Ricaurte? Can we trust that study? wasnt he involved in that bullshit studie done on XTC.
 
How much alpha adrenergic activity does MDPV have? None? Am I correct in this?

So is MDPV therefore a safe stimulant to take with a Beta Blocker?

I was under the belief that only stimulants with alpha adrenoreceptor activity were contraindicated with Beta Blockers, and from what little I've paged through lately, it appears safe to say MDPV is majorly dopaminergic, with little else of worthy note going on...

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Somewhat related question, I had a glowing experience with MDPV + Rhodiola Rosea last week, and since my cabinets are otherwise dry until next month, this is something I'd like to repeat for a bit to see what comes of it.

From what I gather, Rhodiola Rosea has both adrenergic-blocking (apparently general and not Beta or Alpha specific) as well as anti-arrhythmic properties (which I appreciate much, as my heart's never been the stablest since lung surgery about 5 years ago).

Is there any reason to believe such a combo wouldn't actually be both more pleasant, and safer, than just taking MDPV alone?

I found it reduced MDPV's tachycardia while increasing/adding the tinge of euphoria one tends to find is missing with this substance, really balancing the experience out nicely.

Thus the desire for more opinions from more educated minds than mine before repeating this, just in case.

RR also has some Opioid receptor activity and is known to slightly raise monoamine levels through a unique type of mediation, not relating to MAO inhibition. It's really quite a tofu, and I've never found a substance that didn't combine well with it.
 
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I freebased MDPV with baking soda and water in a vaporizer. I know this a crude method.

When done in this manner, it appears that there are other products formed that shouldn't be smoked.

My knowledge of chemistry is limited. I want to know if those end products will adversely affect my health (disregarding the already possible, but probable harmful effects of PV)?
 
LunarSylph said:
How much alpha adrenergic activity does MDPV have? None? Am I correct in this?

So is MDPV therefore a safe stimulant to take with a Beta Blocker?

I was under the belief that only stimulants with alpha adrenoreceptor activity were contraindicated with Beta Blockers, and from what little I've paged through lately, it appears safe to say MDPV is majorly dopaminergic, with little else of worthy note going on...
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I hope somebody can answer this, as I have the same question. I will note that I have seen one report of someone who used a beta blocker to overcome the ill effects of an MDPV overdose, and he didn't mention any problems resulting from it.

I would like to know if it's safe to combine a beta blocker with MDPV in order to make it less likely to get the negative symptoms before they ever happen in the first place? (And would also like to know if it's safe to use a beta blocker to get rid of the negative symptoms if they do occur?)
 
jackjohnson23 said:
I freebased MDPV with baking soda and water in a vaporizer. I know this a crude method.

When done in this manner, it appears that there are other products formed that shouldn't be smoked.

My knowledge of chemistry is limited. I want to know if those end products will adversely affect my health (disregarding the already possible, but probable harmful effects of PV)?
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There's no need to freebase it. The HCl can be foiled as it is. However when smoking MDPV on foil I tend to do it very carefully. If MDPV on foil is exposed rapidly to too much heat it first turns to dark brown/black oil which then vaporizes. This stuff tastes unbeliably nasty.

When heated carefully on foil it almost sublimes and leaves no residue on the foil. If you want to keep foiling PV do it by heating a little bit at the time. I mean it's impossible to inhale 10mg in one go and not get that nasy tasting shite in your lungs. MDPV vapour itself isn't too pleasant tasting either but you can surely notice a different in the taste if you smoke it carefully or give it a blast with a blowtorch.

When injected the effects of MDPV don't come up instantly like with amphetamine or meth. It takes maybe a minute the PV to start working after the plunger has been pushed down. Could someone please enlighten me why this so?
 
When injected the effects of MDPV don't come up instantly like with amphetamine or meth. It takes maybe a minute the PV to start working after the plunger has been pushed down. Could someone please enlighten me why this so?
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Really? I've always noticed the effects almost instantly.
 
Any source for the idea that it's highly selective for DA compared to NA?

If (as I thought) it inhibits NA reuptake too, then, to my amateur knowledge, beta-blockers are not safe, since the NA will "overflow" to the alpha-adrenergic receptors instead, causing strong vasoconstriction.

Btw I'm curious what the exact binding affinities will turn out to be :) Who knows, maybe the unique character is caused by peevee hitting some totally unexpected receptor?
 
Going from a recently published paper on similar compounds, it probably has a higher affinity for NET than for DAT. Most of these pyrovalerone-derived compounds do.
 
LivingOnValium said:
There's no need to freebase it. The HCl can be foiled as it is. However when smoking MDPV on foil I tend to do it very carefully. If MDPV on foil is exposed rapidly to too much heat it first turns to dark brown/black oil which then vaporizes. This stuff tastes unbeliably nasty.

When heated carefully on foil it almost sublimes and leaves no residue on the foil. If you want to keep foiling PV do it by heating a little bit at the time. I mean it's impossible to inhale 10mg in one go and not get that nasy tasting shite in your lungs. MDPV vapour itself isn't too pleasant tasting either but you can surely notice a different in the taste if you smoke it carefully or give it a blast with a blowtorch.

When injected the effects of MDPV don't come up instantly like with amphetamine or meth. It takes maybe a minute the PV to start working after the plunger has been pushed down. Could someone please enlighten me why this so?
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Why can the salt be "fine" to smoke? Does this mean that the effects are about the same salt vs freebase? I know that black/brown oil does taste like shit. Do you happen to know what that chemical is?
 
nuke said:
Going from a recently published paper on similar compounds, it probably has a higher affinity for NET than for DAT. Most of these pyrovalerone-derived compounds do.
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Pity if that's true. Perhaps everyone pimping the addictive-yet-not-euphoric nature of MDPV got me thinking it had more benign receptor affinities, or maybe I really did read somewhere it was DA-selective.

Either way, your input is to be the best trusted (though I'm seconding the desire to hear the the NE/DA spread out of curiosity, whoever might know it), so probably best to just avoid Beta Blockers with MDPV.

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GHB / GBL / Phenibut (the legal choice of the 3) would be a worthy alternative to reduce the negative side-effects of MDPV.

Or like I said earlier, Rhodiola Rosea does seem to calm PV's heart-related activity down:

Rhodiola rosea also offers some cardioprotective benefits not associated with other adaptogens. Its proposed ability to moderate stress-induced damage and dysfunction in cardiovascular tissue might make Rhodiola rosea the adaptogen of choice among patients at higher risk for cardiovascular disease.
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(Source).

The course of administration of Rhodiola rosea extract was studied for effects on the pattern of stress-induced cardiac damage which was assessed by 99mTc-pyrophosphate accumulation in the heart. Rhodiola rosea was found to prevent stress-induced cardiac damage. Simultaneously, myocardial catecholamines and cAMP levels were measured. Rhodiola rosea was ascertained to prevent both stress-induced catecholamine release and higher cAMP levels in the myocardium. Moreover, the adaptogen prevented lower adrenal catecholamines during stress. The findings suggest that the antistressor and cardioprotective effects of Rhodiola rosea are associated with limited adrenergic effect on the heart.
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(Source).

But one still has to wonder whether it's only calming the adrenal activity in particular areas of the heart while PV excites other areas, thus causing the stimulant/blocker danger in another form. Or maybe I'm just overthinking...
 
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jackjohnson23 said:
Why can the salt be "fine" to smoke? Does this mean that the effects are about the same salt vs freebase? I know that black/brown oil does taste like shit. Do you happen to know what that chemical is?
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Smoked (crystal) methamphetamine is always in HCl form. I've also heard 4-fluoroamphetamine HCl can be smoked eaven though there's a huge pile of powder to smoke if you're dosing ~150mg.

IME the smoking the salt (MDPV) very carefully produces an intence high with a nice rush. Not as good as injecting it though.

Freebased PV might smoke better. Never tried but wouldn't be surprised if it was so.

When playing with MDPV I usually inject 15mg to get a strong high with an intence rush. If the same amount could inhaled in one go thje effects would most likely rival what you get when injecting the drug. IVing doses 20mg+ is just asking for trouble (done that also).

I only wish I knew what the black/brown disgusting oil is. It must be a compound formed by decomposition of MDPV due to applying too much heat. Maube someone wiser than me could answer this?
 
Whoa... That's an enormous stim tolerance you had(/have?)

The most MDPV I've ever IVed was 30mg and that was way too intense. That really was taking a step too far for me. I kept 2 hours just praying the effects to subside to a tolerable level.
It surely scared the shit out of me. I will never ever shoot MDPV more than 20mg at a time, i actually find 15mg banged to be more pleasant.
 
MeDieViL said:
Actually i'm glad amphetamine is marketed, what would be the alternative, reboxetine or other garbage?

By the way, Ricaurte? Can we trust that study? wasnt he involved in that bullshit studie done on XTC.
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ooh wow. So he gets paid by some drug war cook to say these drugs are evil... "This brain has no activity after one use"... bullshit like that and in the process he undermines the mighty pharmasutical industrial complex and one of its most marketed drugs, amphetamines and new patent methods of delivering and metabolizing them. Im surprised ppl didn't find out he was full of shit earlier.


Im pretty sure im ok from the amphetamine use so I think the study is wrong unless I just don't realize how fucked I am. And yea fuck ritalene and all that other weak ass shit they prescribe!!
 
Don't dismiss Ricaurte. His group made a genuine mistake, then when it was discovered published a retraction and apology, this is very rare amongst researchers, mostly when they fuck up they keep quiet and hope no-one notices. The amount of bullshit research in the literature is depressing.
 
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