A cute molecule (AI derrivative)

[Jamshyd]

If this ever gets made, I don't care how inactive it is, I want it to be called "Bonbonamine" because it looks like it :D

With that out of the way, the rational behind this is this:

This molecule is to MDAI what IAP is to MDA.

Any speculation as to activity?

 

[dread]

Another chemical masturbation thread?

I suspect you're talking about 5,6-trimethylene-2-aminoindane? I believe it would be a relatively selective serotonin releaser.

I'd be much more interested in 4-methyl-5,6-methylenedioxy-2-aminoindane.

Or 6-methoxy-5-chloro-2-aminoindane.

 

[Jamshyd]

^ Nah, I just wanted to throw it out there that this should be called none other than "Bonbonamine" if it ever gets made. It just CANNOT be named otherwise!!

But yeah, also wondering about activity speculations...

 

[Thou]

If this ever gets made, I don't care how inactive it is, I want it to be called "Bonbonamine" because it looks like it :D

This is adorable and made me smile. That being said, I'll kindly step aside so as not to clutter this forum any longer.

 

[ebola?]

Ill informed guess:
well, if I get your 'deal', the analogy is replacing that 3,4 methylenedioxy substitution with the same one that you have with IAP (what do you call that?). It seems that:
1. bulky substitutions in that region increase 5ht efflux while in certain cases attenuating affinity for NE and DA.
2. with IAP and MDA, 'that other' functional group interferes at NE and DA to a far greater extent than the 3,4...

so wouldn't we turn a highly selective 5ht releaser into...a highly selective 5ht releaser?

ebola

 

[Rectify]

I would venture that bonbonamine would be a very subtle entactogen--so much so that not everyone would feel it--which could be made stronger by the addition of 2 ring activating para methoxy groups on its benzene ring.

 

[dread]

Add methoxy groups to 4 and 8 positions of the phenyl and replace the 2-amino with 1-aminomethyl...

 

[ebola?]

It would be very cool for laypeople (eg, me) if you could explain some of the SAR logic behind your prescriptions.

 

[dread]

I don't wanna! :D


just more mental masturbation about non-existant chemicals...

 

[kobilica]

Actually, I think this chemical exists.

 

[MurphyClox]

Actually, I think this chemical exists.

No, it doesn't, at least not according to 'my' database. None of its stereoisomers was ever published, nor any salt.

Pointless statement

- Murphy

 

[Pomzazed]

No, it doesn't, at least not according to 'my' database. None of its stereoisomers was ever published, nor any salt.

Pointless statement
- Murphy

It doesn't even have a stereocenter

 

[kobilica]

Oh maybe I confused it with amphetamine with same "empty" ring.

 

[fastandbulbous]

It's nice to want silly names fr certain chems (remember my duck/duckling series?)

 

[MurphyClox]

Oh yeah, the 'ducklings' are remembered. That was indeed a nice idea FnB!

@Pomzazed: Oops! Yeah, you're right of course. Silly me! *slap*

 

[Jamshyd]

Can someone please explain the stereocentre thing?

Does this mean that this molecule is impossible?

 

[hugo24]

Of course its possible (some even prefer achiral compounds to synth...), but like MDAI its not chiral as the carbon atom where the amine sticks is symetric (compare to the chiral MDMA which has an asymetric C!).

Therefore MDAI (and Bonbonamine) exist only as one single compound.

 

[fastandbulbous]

Need 4 different groups on a carbon atom (or equivalent for alicyclic/heterocyclic compounds due to position on ring) for it to be a chiral centre. So 1-aminoindan would come in a + & - flavour, but 2-AI is the same heading both ways away from the carbon with the amino groiup attached.

 

[Rectify]

Chiral molecules have nonsuperimposable mirror images of themselves, like your left and right hands for example.

 

[Jamshyd]

^ This I definitely understand.

I was just wondering why Bonbonamine having no chiral centre would have been problematic, but as hugo and FnB explained, it seems to be not a serious issue.