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Fatuous Psychoactive Geography Metaphor

Mr Wobble

Mr Wobble

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Joined
Nov 1, 2009
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Wilf's Quality Meats
If the current state of knowledge of psychoactive compounds were likened to the discovery, exploration and mapping of World geography, what stage are we currently at?

Have we only just discovered the main continents, or are we now filling in the last white bits of the map?

Which is all a roundabout way of asking, how likely is it that there are any really stellar psychoactive compounds in the vane of, for example, LSD still waiting to be discovered?
 
I'd say we're definitely filling in the white bits with the plethora of analogues and variations of the tryptamine and phenethylamines nuclei, but many (including myself) think if anything really dramatic is going to be found it's going to be a new continent.

Say tryptamine and phenethylamine are continents. They've been incredibly mapped out so far with 100s of variations.

What would be revolutionary is finding a whole new chemical nucleus.
 
that may depend on how long the human race survives - there are probably incredible compounds, but we wont be able to synthesize them for thousands or even millions of years.. consider drugs from other planets..! ;)
 
PepperSocks said:
What would be revolutionary is finding a whole new chemical nucleus.
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like phenylpiperazine? :p

ford442 said:
that may depend on how long the human race survives - there are probably incredible compounds, but we wont be able to synthesize them for thousands or even millions of years.. consider drugs from other planets..! ;)
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in thousands of years, we'll hopefully have migrated our consciousness from the flawed biological substrate we're currently using to computers, and so we will have much finer ways for mind-alternation than drugs.
 
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You never know Mr. Wobble, the next LSD might already have been synthesised and just be sitting in some forgotten corner, waiting for the chemist to return his attention to it on a whim and discover its psychic effects accidentally.
 
Yerg said:
You never know Mr. Wobble, the next LSD might already have been synthesised and just be sitting in some forgotten corner, waiting for the chemist to return his attention to it on a whim and discover its psychic effects accidentally.
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Well, that chemist really needs to get on his bike, IMO. ;)
 
The 5-HT2a continent has been settled and thoroughly developed, and her offerings remain bountiful. NMDA antagonist island has been colonized, but only recently have scouts started charting some of its outer banks and conversing with its more esoteric natives--some of whom may be headshrinkers. A wormhole has been opened to the selective kappa opioid receptor agonist dimension, and a few have bungee jumped in and out of it with salvia. But with the sideways gravity it's difficult to tell up from down, much less determine true north. Alternate charting methods may prove revealing in the future, though I suspect settlement of the this mysterium tremendum may be long in coming.

It's impossible to say what's left. I don't think anyone saw the salvia extracts coming. The radical expansion of the scope of possible experience they've brought indicates that the universe of consciousness is indeed still growing rapidly, albeit a bit awkwardly.
 
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Mr Wobble said:
Was the Abby Hoffman allusion too subtle there?

(I was rather pleased with it)
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No it made pefect sense; though now- Abby Hofmann is a dfferent person to Albert Hoffman. The former was a bipolar activist during the sxtes, frends with Jerry Rubin; the latter discovered LSD. ;)

I don't really see the point in this thread tbh :\
 
swilow said:
No it made pefect sense; though now- Abby Hofmann is a dfferent person to Albert Hoffman. The former was a bipolar activist during the sxtes, frends with Jerry Rubin; the latter discovered LSD. ;)
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woops!

I don't really see the point in this thread tbh :\
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It was just a roundabout way of asking the question - are there likely to be many more really interesting discoveries of psychoactive compounds, or have the big ones already been made.

I thought it was an interest area for discussion, albeit, likely conjecture (possibly with some informed opinion).

Apologies if that is not a suitable subject for discussion here.
 
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ford442 said:
that may depend on how long the human race survives - there are probably incredible compounds, but we wont be able to synthesize them for thousands or even millions of years.. Consider drugs from other planets..! ;)
Click to expand...

space drugs!%)
 
Well there's the benzofurans, NBOMe's, potentially other indanes. Just look at the things that have been produced at Purdue post-TiHKAL. There are probably untold thousands of more psychedelics.
 
I was thinking about this the other day. Take LSD for example - its chemical structure is miles away from anything else in TiHKAL, and if he hadn't known about it there's no way Shulgin would have come up with it himself. So, if Hoffmann hadn't got a bit on his fingers all those years ago it might still be completely unknown today - makes you wonder how much else there is out there. My instinctive guess is a lot.

And at present, all or almost all known psychedelics are based around the phenethylamine/tryptamine structures. Does anyone reckon there could other base structures that yield molecules with psychedelic properties, or are we limited to pea's/tryptamines?
 
I think the real unexplored frontiers lay equally in learning how to effectively use what we already have...
 
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