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How toxic is Mephedrone?

vecktor said:
Also can we make an effort to keep the signal to noise higher on this thread. Don't post inane trip reports here, post them in trip reports. I suggest that any future off topic trip reports will be deleted
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Good idea.
 
what scares me most about mephedrone is how even after suffering horrible paranoid delusions, chest pain, and testing positive for heart damage in A and E after a drone binge i still found justification to take it again. i now feel like im dealing with an addiction. as long as i can not physically see it i can stay away from it and thats how i like it. body and mind feel absolutely ravaged.
i also see so so many people actually loving this drug now that i would even go as far to say this is going to be to the UK what methamphetamine is to the US if not worse because its so easily avaliable (not illegal!) , cheap and has a young target audience! . i consider the two on the same level now (based on addictiveness, health problems and basically how it changes people physically and mentally).
after taking stupid amounts for 11 months now ( up tp 10g to myself in a weekend, 400mg bombs of crystal drone every half hour) i urge people to stay away. i started off taking tiny amounts and getting smashed but that has led to an addiction and super-fiending aswell as paranoia and personality change.

i stay away now, hate the stuff.

ps im not trying to look for sympathy im dealing with this problem successfully (staying off sesh in general!), im trying to make new users see that at first it does seem like a wonder drug. it did to me but it took a while before the bad side came out and by then i had loved it too much.
 
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i know someone that takes ADD meds and she reports that after a good day of mephedrone, she has a few days during which she needs 2x her ADD meds (Amphet) augmented with caffeine to get the same effectiveness.

She had also been on an SSRI. she enjoyed meph while on the SSRI, but did not get the 'e' feeling until she was off it for a week or so. also, the effect on her ADD meds was only noticeable after coming off her SSRI.

Is it possible the SSRI has a prophylactic effect similar to what it has to MDMA? (taking an SSRI on the tail end of MDMA use is often cited as a way to minimize problems, as i recall)

personally, i am starting to feel the stuff is not worth the fun, unless you have great self-control and can take it in very limited amounts on a very infrequent basis. I certainly don't fall into that category...
 
also wondering: anyone with a fairly intellectually challenging job or study routine that they have maintained in conjunction with somewhat regular meph use? if so, i would be interested to hear about any noticeable impact on mental performance.. to put in context, a long time ago, i did a lot of k, after a month or so of using it i found i had difficulty concentrating and lost my ability to speak and write quickly and articulately (or the ability was diminished).. this got worse with time. fortunately, as far as i can tell, everything returned in time.

anyone finding themselves struggling to find that word, etc?
 
^ That effect see,s unique to ketamine in my experience as other dissociates such as PCP & the 3 methoxy derivative didn't fuck my speech & motor skills anything like what ketamine did. With ket I was well on the way to becoming a mute due to dimishing vocabulary!
 
I started on an SSRI (Citalopram) about three months ago, and meph wasn't considerably different after I started. I still enjoy the substance quite a bit, but I am tiring of insufflation.

I have a fairly mentally demanding day job (web developer) and after a good meph binge I'm a bit slow and unmotivated. I feel like I have a head cold, and have a kind of fog over me. Some of this could be due to the ROA (nasal congestion -> nasal infection), due to lack of sleep, or due to the actual "hangover' effects of the drugs. My guess is that it is a combination of the three.

Regardless, it isn't significant enough that my coworkers or boss have noticed, and my output isn't significantly damaged as a result.

P.S. Using a neti pot to do nasal irrigation after insufflating mephedrone is highly suggested.
 
squid0 said:
what scares me most about mephedrone is how even after suffering horrible paranoid delusions, chest pain, and testing positive for heart damage in A and E after a drone binge i still found justification to take it again. i now feel like im dealing with an addiction.
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More precise,this sounds like self-destruction.
 
squid0, I'm really worried about you. Anyone who continues to use such a destructive drug after it having damaged their heart is in desperate need of help.
 
Yes i agree with the last posts this is a worrying trail of thought Squid0

You've identified you have an issue. If you don't think you can take a step back then talk to your doc. They cannot squeal on you. I'm actually partial to the view that meow can activate the fight or flight response and obviously, it puts an enormous strain on the old ticker.

But i think the human body can recover from such things, so the important thing is not to dwell and to instead really evaluate where the fun lies and your personal alternatives. Mostly though, i think one thing the body cannot cope with, is losing a night's sleep, which taking Miaow/mkat/plantfood ultimately leads to.

Long term effects = unknown. but palpitations, excessive worrying and tingly skin all point to overexertion. rest is best. remember, no rest for the wicked ;)

peace & love
 
what scares me most about mephedrone is how even after suffering horrible paranoid delusions, chest pain, and testing positive for heart damage in A and E after a drone binge i still found justification to take it again. i now feel like im dealing with an addiction.
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For anybody who thinks mephedrone isn't addictive (it is psychologically very addictive)
 
Addiction & Toxicology

fastandbulbous said:
For anybody who thinks mephedrone isn't addictive (it is psychologically very addictive)
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"in general, the faster a drug has its euphoric effect on the brain, the higher the potential for addiction and toxicity. Rapid onset of euphoria or the "rush" leads to immediate gratification and provides a powerful stimulus for readministration of the drug to maintain the euphoria or "high". Most often, the more rapid the onset of actuation*, the shorter the duration, so that more frequent administration is required."

*actuation meaning put into action, or in this case, stimulation

from: P.110 of Addictions: a comprehensive guidebook, by Barbara S. McCrady, Elizabeth E. Epstein
 
don't really understand your post, Jamshyd? what i can deduce from the above source is that it's the stimulus of gratification that makes a substance addictive, addiction will then lead to tolerance which ensures the strength of the [physical and mental] addiction . not sure that you can get "high" or "euphoric" from alcohol, but having said that i've seen people in different worlds before!!

if anyone can explain toxicology properly i would be very much obliged.
 
This is not a trip report its more for medical reasons
Just wanted to share some stats + something i did out of curiousity.

Stats:
5'8" 150lb 18% fat in my early 20s
i used to be much lower fat and used to do alot of excersise in the past (weight lifting and cardio) but havent done this much for the past 2 years due to elbow injury so i am not muscular anymore and have some flabs now.. Stopped drinking completely 1 year ago because it used to give me elevated pulse/bp even when sober even when i stopped binging and drank in moderation. When i stopped drinking my bp went back to normal and my resting pulse got lower within 6 months.

Experience: With stims? Used some ephedrine/caffiene in the past mephedrone+/methylone aswell

with others:DXM, shrooms, LSA, skunk, poppers, jwh018, salvia, codeine, lyrica, subutex


Last time i did any (before this report) was 4 days ago i had 200mg of methylone x4 + 275mg of mephedrone x1 over 10h. Found the last 3 redoses pointless not much effect apart from stimulant.


Ok its been 4 days since then and im home alone again (in my parents mansion!!!), im gonna see if i can have a relaxed meph buzz.


Before i start, my resting BP:
(4 days clean off evrything apart from jwh-018+/skunk)
111/71
pulse=63


After i check BP i administer 200mg+water (white fine and crystally batch, using a 0.001g scale)
11.07am

+20min
check bp again (sitting, no movement)
129/80
85p

+45 (body orgasming) peaking

machine reads
151/96
p=83


+1.5h coming down still feel good. so im going to take another 50mg, if it doesnt get me im not going to bother with more. going to call it a day now.

no activity. sitting all the way. I approached this buzz with a relaxed attitude, looks like it made my buzz relaxed (hardly any energy) and only a litle jaw clench



it is now +1.6hr resting bp is

149/94

pulse=71


taking some arginine now to lower the bp.

Sorry if it makes no sense i wrote it buzzing. Oh and by the way i diddnt drink much water on this buzz. (im lyin down)


it seems that the dangerous thing about meph is that the physiological effects linger much longer (2-3 days even) than the mental effects. The body load seems to accumulate when redosing while the mental effects do not and sometimes even begin to diminish rendering further redosing futile and even very detrimental to health. The problem is that no one knows if their meph is really pure or even mephedrone at all, and who knows if there are byproducts in certain batches that have actually caused these weird side effects.

Id say this stuff aint so bad if max dose is kept below 500mg (split obviously) and you do it every week or 2 apart at least utilizing multivitamins+sugary electrolyte water+arginine. Going to do another heart assesment in exactly 1 week with methylone or mephedrone again, mabye a bigger initial dose, or a mix of both. I dont want to loose the magic of these chems so im gonna conserve (i have very strong will)
 
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letoureiffel? said:
don't really understand your post, Jamshyd? what i can deduce from the above source is that it's the stimulus of gratification that makes a substance addictive, addiction will then lead to tolerance which ensures the strength of the [physical and mental] addiction . not sure that you can get "high" or "euphoric" from alcohol, but having said that i've seen people in different worlds before!!

if anyone can explain toxicology properly i would be very much obliged.
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First of all, simple addiction is more in the realm of pharmacology than it is in toxicology (the latter of which specifically deals with the study of organic damage brought on by the pharmacological action of substances).

Second, what you posted suggest that you think a substance can only be addictive if it offers a "rush". This is simply untrue.

Alcohol does not offer a rush, and yet it is a very, very addictive substance, both mentally and physically.
 
Meph is psychologically very addicting, having gotten 4 250 mg caps, I wasted them on 3 weekends straight.

On the beginning of the week I still thouht "man this is really bad for me" but at the end of the week I was like "man this weekend will be great again"

Was only able to stop because I stayed at home for a month, but still reordered some knowing that it was bad, forunately my mother found out and took it away from me(which wasn't easy,she needed to talk about 30 min to me before I let go of it, and while I felt first depressed when letting it go, i was somehow relieved)

Also it isn't still clear yet if meph is physically addictive or not, there seems to be some physical WDS. After stopping using it(elictric currents running through your body and having your muscles twitch on it's own when being calm,not unpleasent but scary to think it's a physically WDS)

The batch is got was fine crystally powder but had that digusting smell to it, my mother send it to the laboratory for analysis, so will await the results and post them here.
 
I found it very moreish.....

But I would steer clear of it if you have asthma. I believe it has affected mine. Whether or not it is due to anxiety, or if it has damaged my airways I can't be sure. But it feels like a bit of both! I see people around me getting more and more into it. I think to myself, slow down, you're exhausted! You could have a nice honeymoon. Looking forward to the ^ analysis. It definately causes agitation and nervous system FX. However, overcompensating with ye olde alcomohol now :-?

x
 
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