N&PD Moderators: Skorpio
How toxic is Mephedrone?
PMA no serotonin depleter either,good I can take massive amounts now
We all know why PMA is dangerous, mephedrone is no MAOI so its relevant wheter its a neurotoxin or not. And yeah the biggest issue with meph is the vasoconstriction anyway wich could probebly be avoided by keeping the doses around 300mg.
If it turns out not to cause serotonin depletion, it may be an allright drug in low doses.
So with the current evidence on both sides of the argument, what would your current hypothesis be? Do you feel less or more worried?
Firstly, this thing has suddenly gotten VERY big. The shear volume of sites selling compared to a year ago. If there are short term toxicity problems, unfortunately, I expect we'll here about them by 2nd Jan 2010 from the major news networks.
Obviously the longer term issues....
But with regard to the vasoconstriction side of things. I've found that a 500mg of L-arginine, 250mg of Ginkgo Biloba (leaf based tablet, not the 24mg expensive stuff), 1 multi-vit + 250mg of Trans-Resveratrol basically remove this problem.
The next morning requires a repeat of the above and avoidance of strenuous physical activity, but that's just an added bonus 
I don't take too much Ginkgo, dilation of the vessels is all well and good, but too much, combined with increase bp, I guess that could lead to some un-intended problems.
Does anyone thing the above has mileage, or is my middle name placebo (or worse?).
It would probebly cause serotonin depletion because methcathinone is a known neurotoxic compound, i would bet it isnt as toxic tough, but maybe somewhere around the same level as MDMA.
If this stuff didnt metabolize in an ephedrine like compound there wouldnt have been all those negative reports and ppl wouldnt be as hysterical about it.
But with regard to the vasoconstriction side of things. I've found that a 500mg of L-arginine, 250mg of Ginkgo Biloba (leaf based tablet, not the 24mg expensive stuff), 1 multi-vit + 250mg of Trans-Resveratrol basically remove this problem.
The next morning requires a repeat of the above and avoidance of strenuous physical activity, but that's just an added bonus
I was wondering about using Ginko to counter the vasoconstriction. I have a bottle of them so I will do some investigating the next time I use meph.
...but the main thing to counter it I have found, and it may seem like I am stating the obvious here, is to drink plenty of fluids and keep your self hydrated - before, during and after. Doing that seems to have a huge benefit over not doing it.
I tried Mephedrone for the first time on Saturday morning (4am-7am), we split a gram between three of us over the course of a few hours. I really enjoyed the high, it is definitely better than any pills that I've had in the UK for years, which seem to be extremely shit at the moment, and who knows when they will get any better.
After we finished the gram we drank alcohol for a fair time, I didn't try and get to sleep until 6pm Saturday night, I fell asleep as soon as my head hit the pillow and didn't wake until 7am Sunday, dosed for a few hours and got up around 10am. I felt great, better than a hangover, probably due to so much sleep though, but no emotional shit associated with MDMA. I had a nice Sunday evening and feel fine at work today.
Now, I must admit, reading all the posts on here sound like horror stories, but most of them are when people are taking it everyday, or going on 3 day binges. Splitting a gram between me, my wife and a mate, after clubbing, was great. We only had a gram, and yes, if we had more we would probably have taken it. But we didn't, and we were in no fit state after drinking, pill popping and snorting meph to leave the house to get more.
Therefore, if I take it again, I will always buy a supply that will only last for a short period of time. Too much sounds like a bad idea, just like any drug.
mephedrone metabolism data
Mephedrone metabolism.
looks like my earlier prediction of the paramethyl ephedrine metabolite is correct, although it also makes paramethyl norephedrine by N-demethylation.
from what I am hearing mephedrone users should expect more bad news over the following months.
please use this stuff in strict moderation if you must use it, if you can't moderate your consumption don't take it at all. It is not looking good at the moment.
Also can wemake an effort to keep the signal to noise higher on this thread. Don't post inane trip reports here, post them in trip reports. I suggest that any future off topic trip reports will be deleted
vecktor
http://www.ata-journal.org/articles/ata/pdf/2009/02/ata2009s102.pdf
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unknown
ColtDan
Bluelighter
I was wondering about using Ginko to counter the vasoconstriction. I have a bottle of them so I will do some investigating the next time I use meph.
...but the main thing to counter it I have found, and it may seem like I am stating the obvious here, is to drink plenty of fluids and keep your self hydrated - before, during and after. Doing that seems to have a huge benefit over not doing it.
ive started taking ginko for the same reason. still got red hot hands a few times after a night on meph and booze, not sure if it helped or not tbh. sounds good for me though so i might buy another bottle
cegli
Bluelighter
Considering the fact that MBDB seems to be less toxic than MDMA, and there haven't been too many adverse reactions to bk-MDMA, you would think bk-MBDB would be safer than bk-MDMA. Both of these seem to be much safer than Mephedrone (though that isn't saying much, meth and speed seem safer than mephedrone).
Vecktor is right though, we don't have scientific data on it, but I would bet a lot of money that bk-MBDB (butylone) is much safer.
Operation Atlas
Greenlighter
Butylone has almost nothing in common with mephedrone, as far as effects are concerned. Butylone is almost entirely an empathogen, and there's almost no euphoria and the stimulation is pretty mild.
letoureiffel?
Greenlighter
Toxic meph
Pretty toxic
It's being formally tested now.
it is actually plant fertiliser in addition to khat
http://www.thestar.co.uk/news/Police-warn-youngsters-of-heart.5865372.jp
miracle grow springs to mind
who knows.
some things are too good to be true.
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letoureiffel?
Greenlighter
yes right you are.
cathinone according to wiki is a natural amphetamine found in the shrub - Catha edulis (Khat):
"Cathinone (β-ketoamphetamine) is a monoamine alkaloid found in the shrub Catha edulis (Khat) and is chemically similar to ephedrine, cathine and other amphetamines. Amphetamine induces the release of dopamine from striatal preparations that are prelabelled either with dopamine or its precursors, and it has been shown that cathinone also does this.[1] It is probably the main contributor to the stimulant effect of Catha edulis. Cathinone differs from many other amphetamines in that it has a ketone functional group. Other amphetamines that share this structure include the antidepressant bupropion and the stimulant methcathinone, among others."
Legally: "The sale of khat is legal in Israel (although synthetic cathinone is not), and also in Oman, in Yemen, in United Kingdom and in the Horn of Africa."
why do they mix it with plant fertilising agent then?>>>>?????????
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They dont mix it with plant fertilisers at all, and i sugges to stay away from that news site as either they try to be funny or either they are incredibly stupid.
Artificial Emotion
Bluelighter
How can we let this happen in the media? Isn't there something we can do about this blatant misinformation.
letoureiffel?
Greenlighter
toxicology?
so it could be that the police have misconstrued the "not for human consumption" / plantfood pseudonym?
unless you make it/test it it's hard to be sure.
still i thought it was a wonderdrug. have had amazing times but a memory relapse from thurs. it brought out a very childlike part of my psyche. innerchild perhaps. only so much u can tap into that before you start thinking about meaning of life and such conundrums. 
they need to let bonafide and impartial scientists test it. However, down on the upside = it's classifed by the authorities. peace out.
p.s. i don't make a habit of reading tabloids! there's not that much media coverage and that came out last night 
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